ID F6WHW2_XENTR Unreviewed; 1679 AA.
AC F6WHW2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Myosin VB {ECO:0000313|Ensembl:ENSXETP00000043860};
GN Name=myo5b {ECO:0000313|Ensembl:ENSXETP00000043860};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000043860};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000043860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000043860};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000043860}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR DNASU; 780311; -.
DR Ensembl; ENSXETT00000043860; ENSXETP00000043860; ENSXETG00000020323.
DR Xenbase; XB-GENE-988439; myo5b.
DR eggNOG; KOG0160; Eukaryota.
DR HOGENOM; CLU_000192_9_3_1; -.
DR OrthoDB; 3740797at2759; -.
DR TreeFam; TF328771; -.
DR Bgee; ENSXETG00000020323; Expressed in neurula embryo and 10 other cell types or tissues.
DR ExpressionAtlas; F6WHW2; baseline.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15477; Myo5b_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037990; Myo5b_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF356; UNCONVENTIONAL MYOSIN-VB; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 5.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 5.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782}.
FT DOMAIN 1..627
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1357..1634
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 465..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..528
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 960..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1014..1125
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1186..1268
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 964..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1679 AA; 194619 MW; EC3D179B9FB2B2BF CRC64;
MGDMDPHIFA VAEEAYKQMA RDEKNQSIIV SGESGAGKTV SAKYAMRYFA TVGGSASEAN
VEEKVLASSP IMEAIGNAKT TRNDNSSRFG KYIQIGFDKR YHIIGANMRT YLLEKSRVVF
QADMERNYHI FYQLCASASL PEFSELSLAE AEEFFYTNQG GDPVIDGVDD AEDFEKTRQA
FTLLGVKETH QMGIFKIVAS ILHLGNVAIQ TEREGESCNL SKGDKHLTHF CSLLGLEQDQ
MQHWLCHRKL VTTSETYVKT MSAEQAVNAR NALAKHIYAQ LFNWIVQHVN KALHTTIKQH
SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNSHVF KLEQEEYMKE QIPWTLIDFY
DNQPCIDLIE AKLGILDLLD EECKVPKGTD QNWAQKLYDR HGSSQHFKKP RMSNVAFIVV
HFADQVEYQC DGFLEKNRDT VYEEQINILK ASKYPLVADL FQNEKDTVPP TPTGKSKISV
RPAKPALKSA NKEHKKTVGH QFRNSLHLLM ETLNATTPHY VRCIKPNDYK ESFSFDPKRA
VQQLRACGVL ETIRISAAGY PSRWTYHDFF NRYRVLMKKK DISLGDKKVI CKNVLENLIK
DPDKFQFGRT KIFFRAGQVA YLEKLRADKF RAATIMIQKT VRGWLQRVKY RRMKKAAVTI
QRYTRGHLAR RLALHLRMTK AAITFQKQFR MIRVYRGFQK TRKAAVTIQS YTRGMFVRRA
YRQLLEQHKA AIIQKHWRGW RARKLFSKFR SAAVVIQCYF RRMKARRELK QLKIEARTAE
HFKKLSVGME NKVVQLQRKL DEQNKEQKDL KEQLVSATST HAVEVEKLQK ELEKQRQAQQ
DENQLTSLQQ ELEALREELA KAYSEKKVVE DTLMNEKEQL LQRVSELEEE NTNLKEEKEE
LSNKIILRSE DEFTQSTIKE NLEIKKDLEE ERSRHQNLVK EYTRLEQRYD NLKEEVNIIK
QQMPGHRRNP SNQSSLESDS NYPSISTSEI GDTEDTIKEV EAGLEKAAMD MSLFLKLQKR
VRELELERKK LQSQLDKKEQ QENKKSQVID TTNEVIADRD TDIAYNNLKR QELESENKKL
KNDLNEMRKT IADGAVDGSS EEARIAMLLN QLKSAHEELD VRKEEVLMLR TQIVKAAQQK
ESERIMSSEA SWPNSNKEMD EDDAIEAYHG VCETNRLLEA QLQAQSRQHD EEVEILTSHI
DSLKEELEKQ QQVLLQALQL SPEAQVEFGL QHEITRLTNE NLDLKELLEK SEKNEKKLKK
QLKTYMKKGQ DSEDVVQTER KPELTRQVTV QRIEKDFQGM LEYYKEEEPL LVRNLIIDVK
PEQMSSMVPC LPAYILFMCI RHADYINDDQ KVHSLLTSTI NGIKKVLKKH HSEFQITSFW
LSNSSRLLHC LKQYSGDEGF MTSNSPKQNE HCLRNFDLTE YRQVLSDLSI QIYQQMIKIA
ETHMQPMIVS AMLETESIQG LSGVKQTGYR KRTSSMADGD NSYSLEAVIR QLNTFNSIMC
DHGLDPEIIQ QVFKQLFYMI NAVTLNNLLL RKDVCSWSTG MQLRYNISQL EEWLRGKNLH
PSGAAQTMEP LIQAAQLLQL KKKTEEDAEA ICSLCTALTT QQIVKILNLY TPVNEFEERV
TVSFIRIIQA QLQERNDPPQ LLMDSKYMFP VLFPFSPSAI TLDTIQIPPS LKLDFLMKV
//