GenomeNet

Database: UniProt
Entry: F6WHW5_ORNAN
LinkDB: F6WHW5_ORNAN
Original site: F6WHW5_ORNAN 
ID   F6WHW5_ORNAN            Unreviewed;       473 AA.
AC   F6WHW5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-OCT-2019, entry version 63.
DE   RecName: Full=Protein C-ets-2 {ECO:0000256|PIRNR:PIRNR001698};
GN   Name=ETS2 {ECO:0000313|Ensembl:ENSOANP00000010245};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000010245, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000010245}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000010245};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001698,
CC       ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_001508979.1; XM_001508929.2.
DR   STRING; 9258.ENSOANP00000010245; -.
DR   Ensembl; ENSOANT00000010247; ENSOANP00000010245; ENSOANG00000006420.
DR   CTD; 2114; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000160202; -.
DR   InParanoid; F6WHW5; -.
DR   OMA; RSWNSQS; -.
DR   OrthoDB; 526256at2759; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000006420; Expressed in 7 organ(s), highest expression level in female gonad.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0001712; P:ectodermal cell fate commitment; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR001698,
KW   ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transcription {ECO:0000256|PIRNR:PIRNR001698};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR001698}.
FT   DOMAIN       88    173       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      367    447       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      274    294       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   473 AA;  53744 MW;  BC33E9BE28EB5562 CRC64;
     MSDFGIKNMD QVAPVSNSFR GTLKRQLAFD TFDCPNSLFA GFFPSLNEEQ TLQEVPTGLD
     SISPEPSNCE LPLLTPCSKA VMSQALKATF NGFTKEQCRL GIPNNPWLWT EEQVCQWLFW
     ATNEFSLMDV NFQRFVMNGQ VLCNLGKERF LELAPDFVGD ILWEHLEQMI KENQEKTQDQ
     YLENSHLTSV PHWISSNSLG INVEQLPYGM QTPSYPKMSL LDGVCQASPV PSLLGSEHEF
     HLYSKSRLDT VSVNYCSVNQ DFPRNSLNLL ISNSGKLREP DSSDSGTESF ESSDSMLQSW
     SSQSSLLDVQ RVPSFESFEE DCGQPLCLSK PTMSFKDYIQ ERSDPVEQGK PVIPAAILAG
     FTGSGPIQLW QFLLELLTDK SCQSFISWTG DGWEFKLADP DEVARRWGRR KNKPKMNYEK
     LSRGLRYYYD KNIIHKTSGK RYVYRFVCDL QNLLGYTAEE LHAMLGVQPD TED
//
DBGET integrated database retrieval system