ID F6WI80_CIOIN Unreviewed; 676 AA.
AC F6WI80;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Arachidonate 5-lipoxygenase-like {ECO:0000313|Ensembl:ENSCINP00000015660.3};
GN Name=LOC100178563 {ECO:0000313|Ensembl:ENSCINP00000015660.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000015660.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000015660.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; EAAA01002393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6WI80; -.
DR Ensembl; ENSCINT00000015660.3; ENSCINP00000015660.3; ENSCING00000007639.3.
DR GeneTree; ENSGT00940000165874; -.
DR HOGENOM; CLU_004282_3_3_1; -.
DR InParanoid; F6WI80; -.
DR OMA; FWCHKTV; -.
DR TreeFam; TF105320; -.
DR Proteomes; UP000008144; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IBA:GO_Central.
DR GO; GO:0019369; P:arachidonic acid metabolic process; IBA:GO_Central.
DR GO; GO:0051122; P:hepoxilin biosynthetic process; IBA:GO_Central.
DR GO; GO:0043651; P:linoleic acid metabolic process; IBA:GO_Central.
DR GO; GO:0034440; P:lipid oxidation; IBA:GO_Central.
DR GO; GO:0019372; P:lipoxygenase pathway; IBA:GO_Central.
DR Gene3D; 3.10.450.60; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR InterPro; IPR020834; LipOase_CS.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF5; POLYUNSATURATED FATTY ACID 5-LIPOXYGENASE; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00087; LIPOXYGENASE.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 2..120
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 231..676
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
SQ SEQUENCE 676 AA; 76701 MW; 3F8BCF4B414CF590 CRC64;
TATYTIVFKT NAEFVGSGTD STVSIELFGE DGAVSTGSVK LDQEFYDNFE PGRLDTFTTE
LKDVGLPLIV RIKLKHDTDA KDSLLCDFIK VSVNDQEATF PVCDWIYDEI EVTRGEVVRR
LVKVKNIHLS SMIERELKKA DAKFSWIPRP TENDIGWGFP RYVNAVTYKD LPDVFQRTKI
RQLAQTTNKL ESGIHLMLKQ LESKVLHAHW KTSSLFITCT NERQSRLRMI WDTDEGMGRQ
VLNGISPLVL QKCSKLPNNL NVTNSDVLSS LAPGTTLETN MAAGKIYISD YSEMLEGAIR
NIDPATKLPL HCANSIALFY SKPNEKFVPI AIQLVPGDRN YLFTPSSAEH DWLLAKMYYR
CSQANAHEWL FHYSNTHSVS GTGGTALYKY FPKCHPVFKL LQPHLRTVEA INTDARATLL
PEGSSTNKSM AISATSLARK AYKTFHHNDI VIPKLLKKQG TDDPELLPGY YYRDDAIAHW
KIMEKYIRSV LSFYYKSGED IISDFCLQTW AQGSVTEGIA WQDNNPRGFK SHILSLDELV
EACTTIMFTS SVQHAAVNFG QFETYKYIPN SPFSMRLPPH KVGEGSMARI MNSLPDNGIS
NRSIAVSYTL SQYAPNEVYL GEFPDRLFVE TEIEEIQEEY RKDLQELGKK IEKRNKDLQH
KYTYLHPKNI PNSIAI
//