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Database: UniProt
Entry: F6WJE4_HORSE
LinkDB: F6WJE4_HORSE
Original site: F6WJE4_HORSE 
ID   F6WJE4_HORSE            Unreviewed;      2629 AA.
AC   F6WJE4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   05-JUN-2019, entry version 65.
DE   SubName: Full=Myosin IXA {ECO:0000313|Ensembl:ENSECAP00000014509};
GN   Name=MYO9A {ECO:0000313|Ensembl:ENSECAP00000014509,
GN   ECO:0000313|VGNC:VGNC:20512};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014509, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000014509, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014509,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000014509}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014509};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00782}.
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DR   RefSeq; XP_014589234.1; XM_014733748.1.
DR   PaxDb; F6WJE4; -.
DR   Ensembl; ENSECAT00000017832; ENSECAP00000014509; ENSECAG00000016415.
DR   VGNC; VGNC:20512; MYO9A.
DR   eggNOG; KOG1453; Eukaryota.
DR   eggNOG; KOG4229; Eukaryota.
DR   eggNOG; COG5022; LUCA.
DR   GeneTree; ENSGT00940000154905; -.
DR   InParanoid; F6WJE4; -.
DR   OMA; KPRIGEC; -.
DR   TreeFam; TF316834; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000016415; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   ExpressionAtlas; F6WJE4; baseline.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003774; F:motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0034329; P:cell junction assembly; IEA:Ensembl.
DR   GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd01385; MYSc_Myo9; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 3.40.850.10; -; 2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR028558; MYO9A.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR036023; MYSc_Myo9.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46184:SF3; PTHR46184:SF3; 1.
DR   Pfam; PF00612; IQ; 5.
DR   Pfam; PF00063; Myosin_head; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00015; IQ; 5.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50096; IQ; 4.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874053};
KW   Myosin {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS01033784};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN       14    112       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      146   1016       Myosin motor. {ECO:0000259|PROSITE:
FT                                PS51456}.
FT   DOMAIN     2080   2129       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN     2144   2332       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION     1221   1244       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   REGION     1347   1375       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   REGION     1713   1739       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   REGION     1776   1798       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   REGION     1884   1918       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   REGION     2440   2524       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   REGION     2552   2612       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   COILED     1270   1290       {ECO:0000256|SAM:Coils}.
FT   COILED     1496   1535       {ECO:0000256|SAM:Coils}.
FT   COILED     2407   2434       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1357   1375       Polar. {ECO:0000256|MobiDB-lite:F6WJE4}.
FT   COMPBIAS   1899   1913       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   COMPBIAS   2449   2469       Polar. {ECO:0000256|MobiDB-lite:F6WJE4}.
FT   COMPBIAS   2491   2505       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
FT   COMPBIAS   2506   2524       Polar. {ECO:0000256|MobiDB-lite:F6WJE4}.
FT   COMPBIAS   2577   2591       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F6WJE4}.
SQ   SEQUENCE   2629 AA;  301851 MW;  E17244761856DCDE CRC64;
     MNINDGGRRR FEDNEHTLRI YPGTISEGTI YCPIPARKNS TAAEVIESLI NRLNLDKTKC
     YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG EDYRFLLREK NLDGSIHYGS
     LQSWLRVTEE RRRMMERGFL PQPQQKDFDD LCSLPDLNEK TLLENLRNRF KHEKIYTYVG
     SILIVINPFK FLPIYNPKYV KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE
     SGSGKTQSTN FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI
     QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEEER LAFHLKQPEE
     YHYLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE RLQLAMEMVG FLPKTRRQIF
     SLLSAILHLG NICYKKKTYR DDSIDICNPE ILPIVSELLE VKEEMLCEAL VTRKTVTVGE
     KLILPYKLAE AVTVRNSMAK SLYSALFDWI VFRINHALLN SKDLEQNIKT LSIGVLDIFG
     FEDYENNSFE QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS
     KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEENSYIEF PAVMEPAFII KHYAGKVKYG
     VKDFREKNTD HMRPDIVALL RSSKNAFISG MIGIDPVAVF RWAVLRAFFR AVVAFREAGK
     RHIQRKTGHD DTTPCAILKS MDSFSFLQHP VHQRSLEILQ RCKEEKYSIT RKNPRTPLSD
     LQGMNTLNEK NQHDTFDFSW NGRTGIRQSR LSSSTSLLDK DGIFSNSASS KLLERAHGIL
     TRNKNFKSKP GLPKHLLEVN SLKHLTRLTL QDRITKSLLH LHKKKKPPSI SAQFQASLSK
     LMETLGQAEP YFVKCIRSNA EKLPLRFNDA LVLRQLRYTG MLETVRIRQS GYSCKYSFQD
     FVSHFHVLLP RNIIPSKFNI QDFFRKINLN PDNYQVGKSM VFLKEQERQH LQDLLHQEVL
     RRIIVLQRWF RALLCRQRFL HLRQASIIIQ RFWRNYLNQK QVRDAAVQKD AVVMASAATL
     IQASWRAHLE RQRYLELRTA AVIIQQRWRE LYRRRHMAAI CIQARWKGYR ESKRYQEQRN
     KIILLQSICR GFRARQRFKA LRERRLKETR LELGSSSIEP YGALEIQGSD PSEWEDRSFD
     NRVKAIEEGK SVIESNRISH ESSMDYLKES PNKRQERARS QSGVDLQEDV IVRERPKSLE
     DLHQKKVGRA KRESRRMREL EQAIFSLELL KVRSLGGMSP SEERRWSTEL MPEGFQSLQG
     TPDSGSSQGS LELLSCEESQ KSKLEPIILD EGDFQIPSPK RSSSPKFESQ DNALSASSET
     NYTLIQKGAP SDSVHLKNGT VKEKLGCGSE PITCKPQLRD SFISNSLPTF FYIPPQDPLK
     TISQLDTSIQ RNKLLESEET LPALTLDISR EARKYHFSEA NQVVAYLNTD SSNTVLKKLE
     KLNTEKEERQ KQLQQQNEKE MMEQIRQQTD ILEKERKAFK TIEKPRIGEC SLAPSFHQSK
     RRIERPSSLL ILNTPNKEEP SVLGPLSVSV KDAALAPKDS PSAHLPLKDP HVTLFFERKG
     GPCQSSTVKE LSKTDRMSTQ QNIACKLSNN RISKREHLRP TQYYSHKSDD PSGDGATRAI
     FFTPKDNMSI SLVDKEALNS GNPQLHKQDE PAWKPVKLTG PGQREVARPA HKKKARMART
     RSDFLTRGTF ADGEGDTEED DYDDIIEPLL SLDQASHSEL GPTPSLGQAS HSDSEMTSQR
     FSSVDEEAKL HKTMSQGEIT KLAVRQKASD LDIRPQRAKM RFWAKGKQGE KKTTRVKPAT
     QSEVLALFAG SEMIPAHQFP EELAQYHPTP PLSPELPGSC RKEFKENKEP SPKAKRKRSV
     KISSVALESM QWQNDSVQII ASASDLKSMD EFLLKKMNDL DNEDSKKDTL VDVVFKKALK
     EFRQNIFSFY SSALAIDDGK SIRYKDLYAL FEQILEKTMR LEQRDWNESP VRVWVNTFKV
     FLDEYMNEFK TLDCIPTKVP KTERKKRRKK ETDLVEEHNG HIFKATQYSI PTYCEYCSSL
     IWIMDRASVC KLCKYACHKK CCLKTTAKCS KKYDPELSSR QFGVELSRLT SEDRTVPLVV
     EKLINYIEMH GLYTEGIYRK SGSTNKIKEL RQGLDTDAES VNLDDYNIHV IASVFKQWLR
     DLPNPLMTFE LYEEFLRAMG LQERKETIRG VYSVIDQLSR THLNTLERLI FHLVRIALQE
     DSNRMSANAL AIVFAPCILR CPDTIDPLQS VQDISKTTTC VELIVVEQMN KYKARLKDIS
     SLEFAENKAK TRLSLIRRSM GKGRLHRGNY PSPSSPVVVR LPSMSDVPEE TLTSEAVLET
     DITEQQQAAM QQEERVLTEQ IENLQKEKEE LTFEMLVLEP RASDDETLES EASIGTADSS
     ENLNIESEGA ISEKSERSLA LSSLKAAGKS EPSGKLRKQL KKQQDSLDSV DSSVSSLCSS
     NTASSHGTRK RFQIYSKSPF YRAASAGEAP GMEGLLGQTK SLEDRPQFIS RGTFNPEKGK
     QKLKNVKNSP QKTKETSEGT VVSGHRRTVD PDCSSTQQLA LFGNNEFMV
//
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