ID F6WKL0_CIOIN Unreviewed; 372 AA.
AC F6WKL0; A0A1W5BBQ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Partitioning defective protein 6 {ECO:0000313|Ensembl:ENSCINP00000008202.3};
GN Name=LOC100175009 {ECO:0000313|Ensembl:ENSCINP00000008202.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000008202.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000008202.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01002281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018667826.1; XM_018812281.1.
DR AlphaFoldDB; F6WKL0; -.
DR STRING; 7719.ENSCINP00000008202; -.
DR Ensembl; ENSCINT00000008202.3; ENSCINP00000008202.3; ENSCING00000003983.3.
DR GeneTree; ENSGT00950000183211; -.
DR HOGENOM; CLU_040653_1_0_1; -.
DR InParanoid; F6WKL0; -.
DR OMA; AKRTHHS; -.
DR OrthoDB; 5401122at2759; -.
DR TreeFam; TF312899; -.
DR Proteomes; UP000008144; Chromosome 6.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-KW.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007098; P:centrosome cycle; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0060341; P:regulation of cellular localization; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14102:SF11; LD29223P; 1.
DR PANTHER; PTHR14102; PAR-6-RELATED; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 19..108
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 150..243
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 268..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 41478 MW; 4D23A5E5DCF69C51 CRC64;
MDKLSLGSRG SSPIHGGGLL QVKSKYQAEF RRFPIDLERD GFEDLFHRLE SLHHLTHLQF
VITYTDPQHG DLLPINNDEN FAKAKKSCYN SLMRVYVHRK DNLNVMNGFG QSTVRRRKGK
KTIPKISFPE DFRPVSAIID VDILPETLRR VRLHNHGINK PLGFFIRDGV SLRMSDNGLE
KVPGIFISRL VQGGLAEMTG LLAVNDEVLE VNGIEVGGKS LDQVTDMMVA NSSNLIITVK
PASMKNTMGS TRSRSHERLG IHQMAAQVFE SEEDEDTDVV KDLSEKGRAS DRSTKSSDFP
RPPKRSPNPS PQLNRSGEVI SVSRSNPTHL PPSPKASPAR HNNGDSGRRH KHGKDSLRAK
RTHHSSNPNV SI
//
