ID F6WL34_HORSE Unreviewed; 904 AA.
AC F6WL34;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Exocyst complex component 1 {ECO:0000313|Ensembl:ENSECAP00000021438.2};
GN Name=EXOC1 {ECO:0000313|Ensembl:ENSECAP00000021438.2,
GN ECO:0000313|VGNC:VGNC:17718};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021438.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021438.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021438.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021438.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021438.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SEC3 family.
CC {ECO:0000256|ARBA:ARBA00006518}.
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DR RefSeq; XP_014594225.1; XM_014738739.1.
DR AlphaFoldDB; F6WL34; -.
DR Ensembl; ENSECAT00000025753.3; ENSECAP00000021438.2; ENSECAG00000023793.3.
DR GeneID; 100059087; -.
DR CTD; 55763; -.
DR VGNC; VGNC:17718; EXOC1.
DR GeneTree; ENSGT00940000158640; -.
DR OrthoDB; 6810at2759; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000023793; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6WL34; baseline.
DR GO; GO:0000145; C:exocyst; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd14683; PH-EXOC1; 1.
DR Gene3D; 2.30.29.90; -; 1.
DR InterPro; IPR028258; Sec3-PIP2_bind.
DR InterPro; IPR048628; Sec3_C.
DR InterPro; IPR019160; Sec3_CC.
DR PANTHER; PTHR16092:SF33; EXOCYST COMPLEX COMPONENT 1; 1.
DR PANTHER; PTHR16092; SEC3/SYNTAXIN-RELATED; 1.
DR Pfam; PF15277; Sec3-PIP2_bind; 1.
DR Pfam; PF20654; Sec3_C-term; 1.
DR Pfam; PF09763; Sec3_CC; 1.
DR SMART; SM01313; Sec3-PIP2_bind; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 31..122
FT /note="Exocyst complex component Sec3 PIP2-binding N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01313"
FT REGION 143..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..262
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 474..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 103242 MW; FF98FCC02119541F CRC64;
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK
GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW VASSTAEKNA FISCIWKLNQ
RYLRKKIDFV NVSSQLLEEL PKVTEESVPS GENQSVTGGD EEAVDEYQEL NAREEQDIEI
MMEGCECAIS NAEAFAERLS RELQVLDGAN IQSIMASEKQ VNILMKLLDE ALKEVDQIEL
KLSSYEEMLQ SVKEQMDQIS ESNHLIHLSN TNNVKLLSEI EFLVNHMDLA KGHIKALQEG
DLASSRGIEA CTNAADALLQ CMNVALRPGH DMLLAVKEQQ QHFSELREQF ARRLANHLNN
VFVQQFTQAL LQLYNRSYFL SVPGHDQSST LAQHSVELTL PNHHPFHRDL LRYAKLMEWL
KSTDYGKYEG LTKNYMDYLS RLYEREIKDF FEVAKIKMTG TTKESKKFGL HGSSGKLTGS
TSSLNKLSVQ SSGNRRSQSS SLLDMGNMSA SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ
DFISKFFKLQ QHQSMPGSMT EAEDLDGGTL PRQHNSGAPL PVSSEKDMIR QMMIKIFRCI
EPELNNLIAL GDKIDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTIKRNFDKC
ISNQIRQMEE VKISKKSKVG ILPFVTEFEE FAGLAESIFK NAERRGDLDK AYTKLIRGVF
VNVEKVANES QKTPRDVVMM ENFHHIFATL SRLKISCLEA EKKEAKQKYT DHLQSYVIYS
LGQPLEKLNH FFEGVEARVA QGIREEEVSY QLAFNKQELR KVIKEYPGKE VKKGLDNLYK
KVDKHLCEEE NLLQVVWHSM QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI
AQSH
//
