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Database: UniProt
Entry: F6WNZ7_XENTR
LinkDB: F6WNZ7_XENTR
Original site: F6WNZ7_XENTR 
ID   F6WNZ7_XENTR            Unreviewed;       846 AA.
AC   F6WNZ7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-APR-2018, entry version 37.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a2 {ECO:0000313|Ensembl:ENSXETP00000058886,
GN   ECO:0000313|Xenbase:XB-GENE-960957};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000058886, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000058886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000058886};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000058886}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AAMC01042915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01042916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01042917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01042918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01042919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01042920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01042921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000058886; -.
DR   PaxDb; F6WNZ7; -.
DR   Ensembl; ENSXETT00000066424; ENSXETP00000058886; ENSXETG00000005832.
DR   Xenbase; XB-GENE-960957; atp6v0a2.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; TIPSFMN; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-XTR-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-XTR-77387; Insulin receptor recycling.
DR   Reactome; R-XTR-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-XTR-983712; Ion channel transport.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000005832; -.
DR   ExpressionAtlas; F6WNZ7; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    411    436       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    474       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    569       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   846 AA;  97971 MW;  CD3FC222BCF5350F CRC64;
     MGSFFRSEAM CLAQLFLQSG SAYDCVSELG EMGLAEFRDL NPQVSAFQRK FVGEVKKCEE
     MERILGYLMQ EIQKANIPVP EESLTPEAPL PKHVLDIQEQ LQKLEVELRE VNKNKEKLQK
     NLLEMIEYTY MLRVTNYLVH RSNEHETSAH STYEEFPALE KESLIDYTCM QRLGAKLGFV
     SGLVHRAKLE SFEKMLWRVC KGYTVLTYQE LDEYLLHPDT EEPTRWFVFV VSYWGDQIGQ
     KVKKICECYD CHLYPYTNSA EERRNLLSEL NTRIQDLHKV ISQTDDYLKQ VLFKASESVY
     KWVIQIKKMK AIYHVLNFCR FDVTNKCLIA EVWCPVADLP NVRRALEEGS VRWLCCSTEH
     FCKDIHHQNI FETIVRQSKS SSKYANSVHI KMFNKCIYSN TAPYTIITFP FLFAVMFGDF
     GHGILMSLFA LCMVVFEKSP KLARSQDEIM KTFFEGRYII LLMGLFSIYT GLIYNDCFSK
     SMNIFGSSWN VSAMFSSNVW RTQDLSNKFL TLNPNVTGVL TGVYPVGIDP IWSLSTNRLS
     FLNSFKMKMS VILGVIHMTF GVVLSAFNYM HFKKRFCIFL VFIPELLFMI CIFGYLVFMI
     LYKWLAYSAA DSRNAPSILL HFINMFMFSK NDQIPALFTG QVGIQIFLIV LVTLCVPVLL
     FGKPLYLYWQ HHGGQTLRNY RKGYTLVRRG SEEEISLVRS HDLEEGEINS SHEVQRDRDK
     EKFDFADVFM SQAIHTIEYC LGCISNTASY LRLWALSLAH AQLSEVLWGM IMRKGLNVEP
     SVGVFVLIPL FAVFAFLTIA ILLVMEGLSA FLHALRLHWV EFQNKFYTGA GYKFNPFSFK
     HISHIN
//
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