ID F6WP45_CIOIN Unreviewed; 376 AA.
AC F6WP45; A0A1W2W9E0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Lipopolysaccharide-binding protein {ECO:0000313|Ensembl:ENSCINP00000025896.2};
GN Name=LOC100183082 {ECO:0000313|Ensembl:ENSCINP00000025896.2};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000025896.2, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000025896.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|ARBA:ARBA00007292}.
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DR EMBL; EAAA01000941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002127031.1; XM_002126995.2.
DR AlphaFoldDB; F6WP45; -.
DR STRING; 7719.ENSCINP00000025896; -.
DR Ensembl; ENSCINT00000026142.2; ENSCINP00000025896.2; ENSCING00000014278.2.
DR GeneID; 100183082; -.
DR KEGG; cin:100183082; -.
DR GeneTree; ENSGT01100000263546; -.
DR HOGENOM; CLU_043721_0_0_1; -.
DR InParanoid; F6WP45; -.
DR OMA; AYGYFSA; -.
DR OrthoDB; 2876641at2759; -.
DR TreeFam; TF315617; -.
DR Proteomes; UP000008144; Chromosome 12.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR032942; BPI/LBP/Plunc.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR10504; BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED; 1.
DR PANTHER; PTHR10504:SF131; BPI2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 168..370
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
SQ SEQUENCE 376 AA; 40841 MW; 1BBC588CBB91ED65 CRC64;
MRGQWSVNYR VWFFTVDNDG SFTADASGVD LTLSMRVGRD QNGRPTISST SSCSANIGDM
NARVSGSSLS FLYNILLRFN SNSVRNTFAA RICPTVKSAI QSQANSILRN LNVNYALTTT
TSIDLALSRP PTTASNQITV FSRGRCFPTN NPSMTIPVTA ENLPEFQMTS SHMIRMIVGD
YVINTFLYVQ WVSGSWDFWF GQDSLAGYVG FNFTTDTMAG FLPGFANFGR NRPLRFFVHP
TESPFARTTS ENVNITAKFD LVTFVVAENG SLNDALNISI AASLTGNVTV ENGNLRGQIS
ALTTKSTVSS SKIGDLPVVL VDLIVNNIAQ RLLPSVNNVS MTLQTLPLPS GFGVSNVFVN
TVEHGLEIAT DMTHAG
//
