ID F6WR72_MACMU Unreviewed; 932 AA.
AC F6WR72;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=WD repeat domain 3 {ECO:0000313|Ensembl:ENSMMUP00000011168.3};
GN Name=WDR3 {ECO:0000313|Ensembl:ENSMMUP00000011168.3,
GN ECO:0000313|VGNC:VGNC:78789};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000011168.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000011168.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000011168.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family.
CC {ECO:0000256|ARBA:ARBA00038229}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6WR72; -.
DR SMR; F6WR72; -.
DR Ensembl; ENSMMUT00000011909.4; ENSMMUP00000011168.3; ENSMMUG00000008513.4.
DR VEuPathDB; HostDB:ENSMMUG00000008513; -.
DR VGNC; VGNC:78789; WDR3.
DR GeneTree; ENSGT00940000153859; -.
DR HOGENOM; CLU_005318_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000008513; Expressed in spleen and 20 other cell types or tissues.
DR ExpressionAtlas; F6WR72; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IEA:UniProt.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19853; WD REPEAT CONTAINING PROTEIN 3 WDR3; 1.
DR PANTHER; PTHR19853:SF0; WD REPEAT-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 8.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 58..115
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 61..102
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 103..144
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 145..186
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 187..228
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 411..451
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 492..526
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 587..628
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 629..670
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 671..703
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 806..896
FT /note="Small-subunit processome Utp12"
FT /evidence="ECO:0000259|Pfam:PF04003"
SQ SEQUENCE 932 AA; 104975 MW; 9D6422C58DF7BA33 CRC64;
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI
LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN VTFNGHKAAI TTLKYDQLGG
RLASGSKDTD VIVWDVINES GLYRLKGHKD AITQALFLRE KNLLVTSGKD TMVKWWDLDT
QHCFKTMVGH RTEVWGLVLV SEEKRLITGA SDSELRVWDI AYLQEIEDLE EPDPKKIKGS
SPGVQDTLEA EDGTFEMDEA PEDRILSCRK AGSIMREGRD RVVNLAVEKT GRILACHGTD
SVLELFCILS KEEIKKKMDK KMKKARKKAK LHSCKGEEED PEVNVEMSLQ DEIQRVTNIK
TSAKIKSFDL IHSPQGELKA VFLLQNNLVE LYSLNPSLPT PQPVRTSRIT IGGHRSDVRT
LSFSSDNIAV LSAAADSIKI WNRSTLQCIR TMTCEYALCS FFVPGDRQVV IGTKTGKLQL
YDLASGNLLE TIDAHDGALW SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV
KQTRTLQLDE DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS
YDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT AGKDHKIKQW
DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR LWERTREPLI LEEEREMERE
AEYEESVAKE DQPAVPGETQ GDSYFTGKKT IETVKAAERI MEAIELYREE TAKMKEHTAI
CKAAGKEVPL PTNPILMAYG SISVSKIELE ESLLVLPFSY VPDILKLFNE FIQLGSDVEL
ICRCLFFLLR IHFGQITSNQ MLVPVIEKLR ETTISKVSQV RDVIGFNMAG LDYLKRECEA
KSEVMFFADA TSHLEEKKRK RKKREKLILT LT
//
