ID   F6WSV9_CIOIN            Unreviewed;       361 AA.
AC   F6WSV9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 2.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000004062.2, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA   Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA   Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA   Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA   Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA   Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA   Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA   Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA   Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA   Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA   Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA   Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA   Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000004062.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; EAAA01001499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F6WSV9; -.
DR   STRING; 7719.ENSCINP00000004062; -.
DR   Ensembl; ENSCINT00000004062.2; ENSCINP00000004062.2; ENSCING00000002010.2.
DR   GeneTree; ENSGT00950000183113; -.
DR   HOGENOM; CLU_039228_0_1_1; -.
DR   InParanoid; F6WSV9; -.
DR   OMA; NHFTIHA; -.
DR   TreeFam; TF314270; -.
DR   Proteomes; UP000008144; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004000; F:adenosine deaminase activity; IBA:GO_Central.
DR   GO; GO:0006154; P:adenosine catabolic process; IBA:GO_Central.
DR   GO; GO:0043103; P:hypoxanthine salvage; IBA:GO_Central.
DR   GO; GO:0046103; P:inosine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0060169; P:negative regulation of adenosine receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT   DOMAIN          10..348
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   361 AA;  40475 MW;  97B6EF14D62A89F8 CRC64;
     WNFAMPFDFP KAELHCHLDG CFRLSTCIEL ARERGVELPS YDVNELRSLV CKLQRTASLD
     EYLAHFMVTT PVFAGSREAI KRLTMEAIED KHQQGISYIE FRFCPHLLAD CDVTPRLNAK
     TAGTLTPRGV VEAVCTAAEE ARSRFPVVVR FILCALLDLP DWSMELAHMC KEFALRGVVA
     LDIAGAGIEA DSTFDDHKAA FDFCKEHSID ITVHAGEKGG PNQVHEAVHK LHATRIGHGY
     KTINDKAVYD DVIKKQIHLE VCPISSNLTA SVPEDMTAHP AISFLNDGVN FSLNTDNPGF
     HDADILHDYD VASRMFRFTE EQIKELNLNA LRSSFVEAPM KEKLIKDFKE AYYGNRNSTT
     L
//