ID F6WVV2_MONDO Unreviewed; 695 AA.
AC F6WVV2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Mitotic arrest deficient 1 like 1 {ECO:0008006|Google:ProtNLM};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000021630.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000021630.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000021630.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAD1 family.
CC {ECO:0000256|ARBA:ARBA00008029}.
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DR AlphaFoldDB; F6WVV2; -.
DR STRING; 13616.ENSMODP00000021630; -.
DR Ensembl; ENSMODT00000022007.3; ENSMODP00000021630.3; ENSMODG00000017321.3.
DR eggNOG; KOG4593; Eukaryota.
DR GeneTree; ENSGT00390000001316; -.
DR HOGENOM; CLU_023576_0_0_1; -.
DR InParanoid; F6WVV2; -.
DR OMA; YKLDFMP; -.
DR TreeFam; TF101083; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000017321; Expressed in blood and 18 other cell types or tissues.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.457.60; -; 1.
DR Gene3D; 6.10.250.90; -; 1.
DR InterPro; IPR008672; Mad1.
DR PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR Pfam; PF05557; MAD; 1.
DR SUPFAM; SSF75704; Mitotic arrest deficient-like 1, Mad1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT COILED 84..298
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 337..364
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 434..605
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 695 AA; 81268 MW; 9CE1BFC3446D2C3D CRC64;
MENLEENTAV LSSLRTLKDF ISKPDVEGGS SLNVQYQQSM QLEERAEQIR SKSHLIQVER
EKIQMELSHK RARVELEKAA TTNARNYERE ADRNQELLTR IKQLHERQVE MENKLKEQAE
INRSCKQNLD TANKKLQEKE NKLAEANEWN IMNQEMQVKN LESQKQELME QLDVQNKKCQ
ETNQRVQELQ ANQCLIVDNE QKIKELEQKL SLQEQDAAIV KNMKSELVRF PKMEREVKQL
REENAYLREM KENSGLLKEE VEGLQRKLER HEKLQEDMVA LELEKEKLLE KLKSWERMDQ
SMGLNIRTPE DLSNYIVALQ QRELELTDKS TSITSSARIL EKMRQQLQED LLKVQSQLVE
ERKKREYNEG LARRLQKRVF LLTKERDVMR SILNSFENDL SPAEHSPQLT LQVREAEDMV
QNLHAHSAEM EVQLSQALEE LGEQKGRADM LEVELKILKS QTGSVDQILF VSNDELNALR
LKVEELVTAR NKLEEEKKNL EMQLEQLTLQ GYYDQSKTKV IHLSKNPASL AKGRLKMEQQ
QLQEECQQLQ ELVRVLEGGG TIPNKLEGVG CLQPSQEISD LKKQLESAEL KNQRLKEVFQ
TKIQEFRKVC YTLTGYRIDF TTENQYRLTS MYAEHKSDCL IFKASSPSRT KMQLLETEFS
RTIPELIDLH LLQQDSIPVF LSSVTLDLFS RQTIT
//
