ID F6WVW4_MACMU Unreviewed; 351 AA.
AC F6WVW4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Pre-mRNA-splicing factor 18 {ECO:0000256|ARBA:ARBA00018242};
DE AltName: Full=PRP18 homolog {ECO:0000256|ARBA:ARBA00031388};
GN Name=PRPF18 {ECO:0000313|Ensembl:ENSMMUP00000019753.3,
GN ECO:0000313|VGNC:VGNC:106092};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000019753.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000019753.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000019753.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PRP18 family.
CC {ECO:0000256|ARBA:ARBA00008137}.
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DR RefSeq; XP_015001956.1; XM_015146470.1.
DR AlphaFoldDB; F6WVW4; -.
DR SMR; F6WVW4; -.
DR Ensembl; ENSMMUT00000021126.4; ENSMMUP00000019753.3; ENSMMUG00000015071.4.
DR GeneID; 696401; -.
DR CTD; 8559; -.
DR VEuPathDB; HostDB:ENSMMUG00000015071; -.
DR VGNC; VGNC:106092; PRPF18.
DR GeneTree; ENSGT00390000015073; -.
DR HOGENOM; CLU_3177903_0_0_1; -.
DR OrthoDB; 199348at2759; -.
DR Proteomes; UP000006718; Chromosome 9.
DR Bgee; ENSMMUG00000015071; Expressed in ileum and 23 other cell types or tissues.
DR ExpressionAtlas; F6WVW4; baseline.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 1.20.940.10; Functional domain of the splicing factor Prp18; 1.
DR Gene3D; 4.10.280.110; Pre-mRNA processing factor 4 domain; 1.
DR InterPro; IPR004098; Prp18.
DR InterPro; IPR014906; PRP4-like.
DR InterPro; IPR036285; PRP4-like_sf.
DR InterPro; IPR039979; PRPF18.
DR PANTHER; PTHR13007; PRE-MRNA SPLICING FACTOR-RELATED; 1.
DR PANTHER; PTHR13007:SF19; PRE-MRNA-SPLICING FACTOR 18; 1.
DR Pfam; PF02840; Prp18; 1.
DR Pfam; PF08799; PRP4; 1.
DR SMART; SM00500; SFM; 1.
DR SUPFAM; SSF47938; Functional domain of the splicing factor Prp18; 1.
DR SUPFAM; SSF158230; PRP4-like; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 88..138
FT /note="Pre-mRNA processing factor 4 (PRP4)-like"
FT /evidence="ECO:0000259|SMART:SM00500"
FT REGION 51..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 40812 MW; C43B18A9CCB7BDC6 CRC64;
MDILKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYKPI NEKPSGEIQP
KEEDQKPLTS SNPVLELELA EEKLPMTLSR QEVIRRLRER GEPIRLFGET DYDAFQRLRK
IEILTPEVNK GLRNDLKAAL DKIDQQYLNE IVGGQEPGEE DTQNDLKVHE ENTTIEELEA
LGESLGKGDD HKDMDIITKF LKFLLGVWAK ELNAREDYVK RSVQGKLNSA TQKQTESYLR
PLFRKLRKRN LPADIKESIT DIIKFMLQRE YVKANDAYLQ MAIGNAPWPI GVTMVGIHAR
TGREKIFSKH VAHVLNDETQ RKYIQGLKRL MTICQKHFPT DPSKCVEYNA L
//
