ID F6WY82_MACMU Unreviewed; 764 AA.
AC F6WY82; A0A663DEU1; G7MEQ5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Polymeric immunoglobulin receptor {ECO:0000313|Ensembl:ENSMMUP00000014705.3};
GN Name=PIGR {ECO:0000313|Ensembl:ENSMMUP00000014705.3,
GN ECO:0000313|VGNC:VGNC:75991};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000014705.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000014705.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000014705.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014973384.1; XM_015117898.1.
DR STRING; 9544.ENSMMUP00000080454; -.
DR PaxDb; 9544-ENSMMUP00000014705; -.
DR Ensembl; ENSMMUT00000015697.4; ENSMMUP00000014705.3; ENSMMUG00000011220.4.
DR Ensembl; ENSMMUT00000105440.1; ENSMMUP00000080454.1; ENSMMUG00000011220.4.
DR GeneID; 694638; -.
DR KEGG; mcc:694638; -.
DR CTD; 5284; -.
DR VEuPathDB; HostDB:ENSMMUG00000011220; -.
DR VGNC; VGNC:75991; PIGR.
DR eggNOG; ENOG502QPKT; Eukaryota.
DR GeneTree; ENSGT00940000161667; -.
DR HOGENOM; CLU_020923_0_0_1; -.
DR OMA; IKCYYPA; -.
DR OrthoDB; 5303080at2759; -.
DR TreeFam; TF334441; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000011220; Expressed in colon and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0071751; C:secretory IgA immunoglobulin complex; IEA:Ensembl.
DR GO; GO:0001790; F:polymeric immunoglobulin binding; IEA:Ensembl.
DR GO; GO:0001792; F:polymeric immunoglobulin receptor activity; IEA:Ensembl.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0002415; P:immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IEA:Ensembl.
DR CDD; cd05716; IgV_pIgR_like; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11860; POLYMERIC-IMMUNOGLOBULIN RECEPTOR; 1.
DR PANTHER; PTHR11860:SF87; PROTEIN CD300H; 1.
DR Pfam; PF07686; V-set; 4.
DR SMART; SM00409; IG; 5.
DR SMART; SM00406; IGv; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..764
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014090376"
FT TRANSMEM 639..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..120
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 462..561
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 615..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 83704 MW; 1BB73A05D3E1099E CRC64;
MLLFVLTCLL AVFPAISTKS PIFGPQEVSS VEGNSVSIKC YYPPTSVNRH TRKYWCRKGA
SGRCITLVSS EGYVSSNYAG RANLTNFPEN GTFVVNIAQL SRDDSGHYKC GLGINSRGLS
FDVSLEVSQG PELPNDTEVY TVDVGRTVTI KCPFKTENAP KTKALYKKIG QTSVLVIDSR
NYVNPNYKDR IRLRIPGTGQ LIFTIVIDRL RLSDHGLYLC QAGDGSNRDE KNADLQVLEP
EPELVYEDLR GSVTFHCALG LEVANVAKFL CRVNSRETCD VVINTLGKRD SAFEGRILLN
PQDKDGSFSV VITGLRKEDE GRYLCGAHSD GQLQEGWPIQ AWQLFVNEES TIPRSPTVVK
GVAGGSVAVL CPYNPKESQS LKYWCLWEGA QNGRCPLLVE SQGLVQEQYE GRLSLLQEPG
NGTFTVILNQ LTTQDAGFYW CLTNGDTRWR TTVEIKIIEG EPNLKVPGNV TAVLGETLNI
PCHFPCKFSS YEKYWCKWSN TGCQTLPSQD EGPSEAFVNC DENSRLVSLT LNPVTRADEG
WYWCGVKQGH FYGETAAVYV AVEEKKVAGS RDVSPAKADA APDEKVLDSG VREIENKAIQ
DPRLFAEEKV VADTGDQAGG SRASVDSSSS EEQGGSSKAL VSTLVPLGLV LALGAVVVGV
ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA SSITQETSLG GKDEFVATPE
STTETKEPKK AKRSSKEEAE MAYKDFLLQS STMATEAQEG PQEA
//
