ID F6WZ55_MONDO Unreviewed; 2069 AA.
AC F6WZ55;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Dedicator of cytokinesis 11 {ECO:0000313|Ensembl:ENSMODP00000014132.4};
GN Name=DOCK11 {ECO:0000313|Ensembl:ENSMODP00000014132.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014132.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000014132.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000014132.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 13616.ENSMODP00000014132; -.
DR Ensembl; ENSMODT00000014393.4; ENSMODP00000014132.4; ENSMODG00000011503.4.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000155658; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR InParanoid; F6WZ55; -.
DR OMA; YDHYIPL; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000002280; Chromosome X.
DR Bgee; ENSMODG00000011503; Expressed in blood and 18 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 165..272
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 641..819
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1604..2031
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 275..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2069 AA; 236663 MW; 5374DCFC90D8084B CRC64;
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRS SVVLEKAKVV EPLDYENVIT QRKAQIYSDP
LRDLLMFPME DLSVSVIARQ RRTVESTVPE DAEKKAQSLF VKECIKTYSS DWHVVNYKYE
DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC EKDEDSSSLC SQKGGMIKQG WLFKANVNST
ITVTMKVFKR RYFYLTHLPD GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF
ELKMLDKYSH YLAAETEQDM EEWLTTLRKI IQINTDSSGQ EKKEPVESIQ EDETSSQGKP
ENIMESLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DADVQRLDFS GIEPDIRPFE
EKCSRRFIVS CHDFNFNILA HVGDSAQGPP TNVEPFFLNL ALFDVKNNCK ISADFHVDLN
PPSIREMLLG LSAHVDNDGT PRGSSSKEHF IHGIEESQLR YIKQGIFSVT NPHVEIYLVA
RIEKVLQGSI THCAEPYIKT SDPVKTAQKV HKAARQVCNR LGRYRMPFAW AARPVFKDTQ
GSLDLEGRFS PFYKQDSSKL SSEDILKLLS EYKKPEKTKL QIIPGQLNII IECVPPDFSN
CVTASYVPVK PFLKNSQNLA VEIEEFVPEV AKYCYPFTVY KNHLYVYPLH LKYDSQKTFA
KARNIAVCVE FRDSDESDAS ALKCIYGKPA GPLFVTNAFA IVSHHNQNPE FYDEVKIELP
IHLHQKHHLL FTFYHISCEI NTKGTAKKQD TVETLVGFAW VPLLKDGRVI TFEQQLPVSA
NLPPGYLSLA DPESRRQPNI DIKWVDGAKP LLKIKTHLES TIYTQDLHVH KFFRHCQAMQ
SGAKAVPGEL IKYLKCLHAM EIQVMIQFLP VILTQLFRVL TNMTQEDDVA INCTMVLLHI
VSKCHEEGLD HYLRSFLKYS FRAEKPGAPQ AQMTHEILAT AMTTALKQSA DFLAINKLLK
YSWFFFEALA KSMASYLLEE NKIKLPRAQR FPESYHHVLH SLLLAIIPHV TIRYGEIPEE
SRNVNYSLAN FLKRCLTLMD RGFIFNLIND YMSGFSPKDP KVLAEYKFEF LQTVCNHEHY
IPLNLPMAFA RPKLQRVQGT SRSYSSLESS LSDEYCKHHF LVGLLLRETS IALQDNYEIR
YLAITVIKHL LIKHAFDTRY QHKNQQAKIA QLYLPLIGLL LENIQRLVGR DTLYSCTAMP
SSASRDEFVC GFTSPSNRAS LVAEKDAAYG ASFPNGHGIK REDSRGSLST DVVGSSPDQS
GTRRSSTRSS ISQYNRLDQY EIKSLLMCYL YIIKMISEDT LLTYWNKVSP QELINILLIS
LLMSCLHFRV HDAWLSKHFG IDRKSQTMPA LRSRAGVMQA RLQHLSSLES SFTLNHSSGT
SEADIFHQAL LEGNTATEVS LTVLDTISFF TQCFKNQLLN NDGHNPLMKK VFDIHLAFLK
NGQSEASLKH VFASLRAFIS KFPSAFFKGR VTMCAAFCYE VLKCCTSKVS STRNEASALL
YLLMRSNFEF TKRRTFLRTH LQIIIAVSQL IADVALSGGA RFQESLFIVN NFANSDRPMK
ATAFPAEVKD LTKRIRTVLM ATAQMKEHEK DPEMLIDLQY SLAKSYASTP ELRKTWLDSM
AKIHTKNGDF SEAAMCYVHV AALVAEFLHR KKLFSSGCSA FKKITPNIDE EGAMKEDAGM
MDVHYSEEVL LELLEQCVDG LWKAERYEVI SEISKMIIPI YEKRREFEKL TQVYRTLHGA
YTKILEVMHT RKRLLGTFFR VAFYGQAFFE EEDGKEYIYK EPKLTGLSEI SLRLVKLYGE
KFGADNVKII QDSDKVNVKD LDPKYAYIQV TYVKPYFEDK ELSERKTEFE KNHNINRFVF
EAPYTLSGKK QGSVEEQCKR RTILTTSNSF PYVKKRIPIN YEQQINLKPI DVATDEVKDK
TAELQKLCSA ADVDMIQLQL KLQGCVSVQV NAGPLAYARA FLSDHQASKY PTKKVNELKD
MFRKFIQACS IALELNERLI KEDQIEYHEG LKSNFRDMVK ELADIIHEQM FQEDTMHSPW
MNNTLHVFCA ISGTSGDGGF GSPRYMAEV
//
