ID F6X0I8_XENTR Unreviewed; 3186 AA.
AC F6X0I8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Vacuolar protein sorting 13 homolog A {ECO:0000313|Ensembl:ENSXETP00000007804};
DE SubName: Full=Vacuolar protein sorting-associated protein 13A {ECO:0000313|RefSeq:XP_031746767.1};
GN Name=vps13a {ECO:0000313|Ensembl:ENSXETP00000007804,
GN ECO:0000313|RefSeq:XP_031746767.1,
GN ECO:0000313|Xenbase:XB-GENE-989613};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000007804};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000007804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000007804};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000007804}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031746767.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031746767.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031746767.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR RefSeq; XP_031746767.1; XM_031890907.1.
DR Ensembl; ENSXETT00000007804; ENSXETP00000007804; ENSXETG00000003616.
DR KEGG; xtr:100488998; -.
DR Xenbase; XB-GENE-989613; vps13a.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_000135_1_1_1; -.
DR OMA; PYRVDNF; -.
DR TreeFam; TF300316; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000003616; Expressed in skeletal muscle tissue and 15 other cell types or tissues.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..370
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 572..795
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1156..1252
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1951..2467
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2777..2954
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 2959..3047
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3048..3161
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 1028..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1031..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3186 AA; 358273 MW; EF0A4017D1765E76 CRC64;
MVFESLVVDV LNRFLGDYVV NLDSSQLKLG IWGGAVALKN LEIKENALSQ LDVPFKVKAG
HIGKLDLKIP WKNLYTQPVE AVLDGVYLLI VPTASIKYDA EKEEKQSLEA KQRELQRIEE
AKQKVADQEK PKEEKQDTFV EKLITQVIKN LQVKISNIHI RYEDDITNPK CPLSFGVSLQ
NLSLQTSDKN WNPCLHDESA KLFYKLVRLD NLFAYWNVKS DMFYHRSYDT ALEILKYGIA
ARNTIPEGYD FVFRPISGRA KLRMNPRSDV DFSSPKIDLD VNLQDIAIDF NKPQYHSVME
LLESIDLMSR NLPYRKFRPD VCVATNAPIW WKYAITSILE VNIKPRLHMW SWKRIRKHRL
QVKKYKELYR MKITSKKPSE EVLSKTEEYE KALDIFNITL ARQQAEMEAC KAGLKIYRPG
SKDEDCNSKG WFGWMWGWSG ETAEKKEDFK SGSLEGLMSP EEKVRLYAAI GYSETAVDPT
LPKTYEAMRL CVKLLSMSIQ LREDKGKTEL INFAITDLST VLKQRPGAQA IKFEAQIGTF
EVTGTPQEKS VPCVLSSRNL IENNISLLSL MFETNPLDER ADQKLQVESQ PLEIIYDAKT
INNLVDFFRP PQDVHLEQLA SATMTKLEEF RDRTSTGLLY VIETQKVLDL KINLMASYII
VPENGFYEQS SNLLLLDLGS LKMVSKSRSH LPQLKIGQSS IEDIMSRAYD SFDVQLSKMQ
LLYRKNNEDW KKARNLKRSS LHILEPMDLK VEFSRAMVVT DARMPKCKLS GELPILSIQI
SDQKLKGVLE LIDSIPKPES PPEPYPSPQK IAIQKSTSVV NTPQLAPRRP AIVDLPSLIE
SESEEEFYDA PTSPVDEKPF FEVSSGAVAR TDSLRKKKLK RQETQKNMTE FQMRFEIPTV
TIQLCSLSKD VEKTVLHLEI MGLGTELNVR TFDMSANAFL REISLKCPQY TDDEKRPVYI
ITTLDNTTDD LLTLEYIKAD INGPEFKTTY KNVEQLIKVN FSSLDIHLHT EALLSTMSFL
TSLVPQSERK EMDQPVQDSE EEKREEQKKT TIKKSKYDDV VNLHVCAELS CLRVFIRGQK
CRISEISIEG LDSQVVITKK ATEVLAKLKN IAILDCDPEA NFKKAVCIKG KEFFSFKMVS
YVGATEGDAY RDMSVVDSHI TLNVGCIQVI FVNKFVSAIL AFINNFQATK QALAEATVHA
AEKAASGVKE LAQHSFRLAL DIHVKAPVVI VPQSSKSSQV LVADLGLITV NNKFSIVIPK
SHSNLPPVID SMMINLSELK MYRTVYENGS LQSELQLLQP VNLDITIERN LAADWYHDVP
DIKIIGHLKP MNLILGQEDL TLILQTLNEN LGETSELFPA ESDDETLVSG DNSSSHSAGT
TVVTAAVVET YSPVKIKTTL KLDFQFDSLT LNLYSGKTFV LQGSVHERDS SLKLAEFKLG
LISLAVKMSS DGTVNAAVKL TNCLLDDKRQ SVQKATPRML EMKVGTEKNV MVDVSYKQGR
EGTILDVTVR DVYLCASMEF LLTVADIFLK ASQQSSKAEK SIKQTSAPVK ESAPTQQVSK
MEMNVVVKNP EIVFVADLSR ADAPALVVTT QCELCIKTSP EMQNMTAAVK DLHMKACPFL
SDQRAGKITT ILQPCDLFFQ SIQSNSGPQM IELSIKSLML KVSPVIINTV ITITSAISSN
KEAVSEVTSP VSPDLWKKKN LKDLKMWFFE ESKESENKPE ESSNMVLTGE TLKMSIESII
VTLEAGVGHR TLPMLLAKSS FSGNVTNWST LINLYCQLEL EVHCFNEMFG VWEPLVEPLE
VDKTDSFRPW NLGVKMKKKA REQICEPDGE EENYKIPEYI TAISIFSKDH LNITLSKCGM
ATLGNLANAF TDAASKKCDA CKIDQAPFVV KNYLGLLVSV SPSDSFKPLN SAAGSKKIDL
HDGECLDMDY VQSKSQTDQF SAMTSLSSKH FYIQLTPLDH SHTDKIPLTK VGRSLYCVRH
LVSGIERYIV CQVDSVEGTK CITIRSPLQI RNHFSIPIGI YEEGVCLGTA SPEDEFNIPL
ASYRSVLCFK PVQEKKYEMS EGVSFEDVIK NDGLLLNMKC QSATSKKDSL KLNIVPVKDI
VMSSDHTNEG WHLPYVVHLW PTVVLRNLLP YQIKFSLQGV DVDATLVDDG CSTQIHNAAL
DNTKLKLQLL NYTDQGWTAE YHIQSKQQDI HFINFRCVAE LDKSELDIAV HVTYTTGQTI
IALHSPYWMV NKTGRMLQYK ADDIHRKHPA DHKKPLLFSF KPKNFLQNNK VQLMITDSEL
SDPFSLDTVG SHGAVKCKSK KLDYQVGVTI YASSFNLTRI VTFTPFFMVA NRSNYTLSVA
EEGSEKCITV STEQCVPFWP ENSNNKLIVQ VEGSKAAPKK IYFNKQDNST LLYLGDQFGG
ILVDVTLRDH STVITFSDYH AGAAPFLIIN DMKSETVTFF QSSVNEEKDC LPPGKAVLYA
WKDPTSERKL TWICRKSQGE VSQTEDRVEY LRLEDTSVYL VSFLEGLQRI LLFTENESVF
NVTFDNQKAE LAEQEIIISL SNIGISLVNN YTKQEVSYIG ITNSDVVWET KKKSRWKPLS
IKQTEKLEQA FKEYTESSPT DTKIVALDTN CQVCLTPDFS GMKFIQPTTD PIRRSFLPAL
KLEYSASAHQ TSIRLQVYRI QIQNQNPAAI FPFVFYPVKP PKSVTLDSEP KPLTDVSIVM
RTAGHSEISR IKYFKVLIQE MDLRIDLGFL YALADLFSQS GDVPKDQAIE LFKKDVESFQ
TELSAVSSTD TSSISVYEYF HISPIKLHLS FSLSTGGDDG NKEQRDKELI PVQSLNLLLK
SIGATLTDVQ DVVFKLAYFE LQNQFYTTQE LQWEVIRHYS KQAIKQMYVL VLGLDVLGNP
FGFFRDLSEG VEAFFYEPYQ GAIQGPEEFV EGMALGVKAL VGGAVGGLAG AASRITGAMA
KGVAAITMDE EYQQKRREAM NKQPSGIREG ITRGGKGLVS GFVSGITGIV TKPIKGAQKE
GAAGFFKGVG KGLVGAVTRP TGGIIDMASS TFQGIKKATD SSDDVESLRP PRFIHEDGVI
RPYRMREGAG SQMLQKIENG RFAKCKYFAH AMVNSSDLLM VMKSGVLFVT RGTFGQLTCE
WQYSFDEFTK EPFIVSGRRL RIEAKERVKS VFHAKEFGKI INFRTPEEAK WILCKLEEVR
DAQTKT
//