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Database: UniProt
Entry: F6X0I8_XENTR
LinkDB: F6X0I8_XENTR
Original site: F6X0I8_XENTR 
ID   F6X0I8_XENTR            Unreviewed;      3186 AA.
AC   F6X0I8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 4.
DT   24-JAN-2024, entry version 66.
DE   SubName: Full=Vacuolar protein sorting 13 homolog A {ECO:0000313|Ensembl:ENSXETP00000007804};
DE   SubName: Full=Vacuolar protein sorting-associated protein 13A {ECO:0000313|RefSeq:XP_031746767.1};
GN   Name=vps13a {ECO:0000313|Ensembl:ENSXETP00000007804,
GN   ECO:0000313|RefSeq:XP_031746767.1,
GN   ECO:0000313|Xenbase:XB-GENE-989613};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000007804};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000007804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000007804};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000007804}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:XP_031746767.1}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031746767.1};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031746767.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC   -!- SIMILARITY: Belongs to the VPS13 family.
CC       {ECO:0000256|ARBA:ARBA00006545}.
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DR   RefSeq; XP_031746767.1; XM_031890907.1.
DR   Ensembl; ENSXETT00000007804; ENSXETP00000007804; ENSXETG00000003616.
DR   KEGG; xtr:100488998; -.
DR   Xenbase; XB-GENE-989613; vps13a.
DR   eggNOG; KOG1809; Eukaryota.
DR   HOGENOM; CLU_000135_1_1_1; -.
DR   OMA; PYRVDNF; -.
DR   TreeFam; TF300316; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Bgee; ENSXETG00000003616; Expressed in skeletal muscle tissue and 15 other cell types or tissues.
DR   GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR015412; Atg2/VPS13_C.
DR   InterPro; IPR026847; VPS13.
DR   InterPro; IPR026854; VPS13-like_N.
DR   InterPro; IPR049424; VPS13_C.
DR   InterPro; IPR031645; VPS13_DH-like.
DR   InterPro; IPR031646; VPS13_extend_chorein.
DR   InterPro; IPR031642; VPS13_mid_RBG.
DR   InterPro; IPR009543; VPS13_VAB.
DR   PANTHER; PTHR16166:SF22; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13A; 1.
DR   PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR   Pfam; PF09333; ATG2-VPS13_C; 1.
DR   Pfam; PF12624; Chorein_N; 1.
DR   Pfam; PF21679; VPS13_C; 1.
DR   Pfam; PF16909; VPS13_DH-like; 1.
DR   Pfam; PF16908; VPS13_ext_chorein; 1.
DR   Pfam; PF16910; VPS13_mid_rpt; 2.
DR   Pfam; PF06650; VPS13_VAB; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          3..116
FT                   /note="Chorein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12624"
FT   DOMAIN          139..370
FT                   /note="Vacuolar protein sorting-associated protein 13
FT                   extended chorein"
FT                   /evidence="ECO:0000259|Pfam:PF16908"
FT   DOMAIN          572..795
FT                   /note="VPS13 middle RBG modules"
FT                   /evidence="ECO:0000259|Pfam:PF16910"
FT   DOMAIN          1156..1252
FT                   /note="VPS13 middle RBG modules"
FT                   /evidence="ECO:0000259|Pfam:PF16910"
FT   DOMAIN          1951..2467
FT                   /note="Vacuolar protein sorting-associated protein 13 VPS13
FT                   adaptor binding"
FT                   /evidence="ECO:0000259|Pfam:PF06650"
FT   DOMAIN          2777..2954
FT                   /note="Vacuolar protein sorting-associated protein 13 DH-
FT                   like"
FT                   /evidence="ECO:0000259|Pfam:PF16909"
FT   DOMAIN          2959..3047
FT                   /note="Atg2/VPS13 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09333"
FT   DOMAIN          3048..3161
FT                   /note="Intermembrane lipid transfer protein VPS13 C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21679"
FT   REGION          1028..1051
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          98..128
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1031..1051
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3186 AA;  358273 MW;  EF0A4017D1765E76 CRC64;
     MVFESLVVDV LNRFLGDYVV NLDSSQLKLG IWGGAVALKN LEIKENALSQ LDVPFKVKAG
     HIGKLDLKIP WKNLYTQPVE AVLDGVYLLI VPTASIKYDA EKEEKQSLEA KQRELQRIEE
     AKQKVADQEK PKEEKQDTFV EKLITQVIKN LQVKISNIHI RYEDDITNPK CPLSFGVSLQ
     NLSLQTSDKN WNPCLHDESA KLFYKLVRLD NLFAYWNVKS DMFYHRSYDT ALEILKYGIA
     ARNTIPEGYD FVFRPISGRA KLRMNPRSDV DFSSPKIDLD VNLQDIAIDF NKPQYHSVME
     LLESIDLMSR NLPYRKFRPD VCVATNAPIW WKYAITSILE VNIKPRLHMW SWKRIRKHRL
     QVKKYKELYR MKITSKKPSE EVLSKTEEYE KALDIFNITL ARQQAEMEAC KAGLKIYRPG
     SKDEDCNSKG WFGWMWGWSG ETAEKKEDFK SGSLEGLMSP EEKVRLYAAI GYSETAVDPT
     LPKTYEAMRL CVKLLSMSIQ LREDKGKTEL INFAITDLST VLKQRPGAQA IKFEAQIGTF
     EVTGTPQEKS VPCVLSSRNL IENNISLLSL MFETNPLDER ADQKLQVESQ PLEIIYDAKT
     INNLVDFFRP PQDVHLEQLA SATMTKLEEF RDRTSTGLLY VIETQKVLDL KINLMASYII
     VPENGFYEQS SNLLLLDLGS LKMVSKSRSH LPQLKIGQSS IEDIMSRAYD SFDVQLSKMQ
     LLYRKNNEDW KKARNLKRSS LHILEPMDLK VEFSRAMVVT DARMPKCKLS GELPILSIQI
     SDQKLKGVLE LIDSIPKPES PPEPYPSPQK IAIQKSTSVV NTPQLAPRRP AIVDLPSLIE
     SESEEEFYDA PTSPVDEKPF FEVSSGAVAR TDSLRKKKLK RQETQKNMTE FQMRFEIPTV
     TIQLCSLSKD VEKTVLHLEI MGLGTELNVR TFDMSANAFL REISLKCPQY TDDEKRPVYI
     ITTLDNTTDD LLTLEYIKAD INGPEFKTTY KNVEQLIKVN FSSLDIHLHT EALLSTMSFL
     TSLVPQSERK EMDQPVQDSE EEKREEQKKT TIKKSKYDDV VNLHVCAELS CLRVFIRGQK
     CRISEISIEG LDSQVVITKK ATEVLAKLKN IAILDCDPEA NFKKAVCIKG KEFFSFKMVS
     YVGATEGDAY RDMSVVDSHI TLNVGCIQVI FVNKFVSAIL AFINNFQATK QALAEATVHA
     AEKAASGVKE LAQHSFRLAL DIHVKAPVVI VPQSSKSSQV LVADLGLITV NNKFSIVIPK
     SHSNLPPVID SMMINLSELK MYRTVYENGS LQSELQLLQP VNLDITIERN LAADWYHDVP
     DIKIIGHLKP MNLILGQEDL TLILQTLNEN LGETSELFPA ESDDETLVSG DNSSSHSAGT
     TVVTAAVVET YSPVKIKTTL KLDFQFDSLT LNLYSGKTFV LQGSVHERDS SLKLAEFKLG
     LISLAVKMSS DGTVNAAVKL TNCLLDDKRQ SVQKATPRML EMKVGTEKNV MVDVSYKQGR
     EGTILDVTVR DVYLCASMEF LLTVADIFLK ASQQSSKAEK SIKQTSAPVK ESAPTQQVSK
     MEMNVVVKNP EIVFVADLSR ADAPALVVTT QCELCIKTSP EMQNMTAAVK DLHMKACPFL
     SDQRAGKITT ILQPCDLFFQ SIQSNSGPQM IELSIKSLML KVSPVIINTV ITITSAISSN
     KEAVSEVTSP VSPDLWKKKN LKDLKMWFFE ESKESENKPE ESSNMVLTGE TLKMSIESII
     VTLEAGVGHR TLPMLLAKSS FSGNVTNWST LINLYCQLEL EVHCFNEMFG VWEPLVEPLE
     VDKTDSFRPW NLGVKMKKKA REQICEPDGE EENYKIPEYI TAISIFSKDH LNITLSKCGM
     ATLGNLANAF TDAASKKCDA CKIDQAPFVV KNYLGLLVSV SPSDSFKPLN SAAGSKKIDL
     HDGECLDMDY VQSKSQTDQF SAMTSLSSKH FYIQLTPLDH SHTDKIPLTK VGRSLYCVRH
     LVSGIERYIV CQVDSVEGTK CITIRSPLQI RNHFSIPIGI YEEGVCLGTA SPEDEFNIPL
     ASYRSVLCFK PVQEKKYEMS EGVSFEDVIK NDGLLLNMKC QSATSKKDSL KLNIVPVKDI
     VMSSDHTNEG WHLPYVVHLW PTVVLRNLLP YQIKFSLQGV DVDATLVDDG CSTQIHNAAL
     DNTKLKLQLL NYTDQGWTAE YHIQSKQQDI HFINFRCVAE LDKSELDIAV HVTYTTGQTI
     IALHSPYWMV NKTGRMLQYK ADDIHRKHPA DHKKPLLFSF KPKNFLQNNK VQLMITDSEL
     SDPFSLDTVG SHGAVKCKSK KLDYQVGVTI YASSFNLTRI VTFTPFFMVA NRSNYTLSVA
     EEGSEKCITV STEQCVPFWP ENSNNKLIVQ VEGSKAAPKK IYFNKQDNST LLYLGDQFGG
     ILVDVTLRDH STVITFSDYH AGAAPFLIIN DMKSETVTFF QSSVNEEKDC LPPGKAVLYA
     WKDPTSERKL TWICRKSQGE VSQTEDRVEY LRLEDTSVYL VSFLEGLQRI LLFTENESVF
     NVTFDNQKAE LAEQEIIISL SNIGISLVNN YTKQEVSYIG ITNSDVVWET KKKSRWKPLS
     IKQTEKLEQA FKEYTESSPT DTKIVALDTN CQVCLTPDFS GMKFIQPTTD PIRRSFLPAL
     KLEYSASAHQ TSIRLQVYRI QIQNQNPAAI FPFVFYPVKP PKSVTLDSEP KPLTDVSIVM
     RTAGHSEISR IKYFKVLIQE MDLRIDLGFL YALADLFSQS GDVPKDQAIE LFKKDVESFQ
     TELSAVSSTD TSSISVYEYF HISPIKLHLS FSLSTGGDDG NKEQRDKELI PVQSLNLLLK
     SIGATLTDVQ DVVFKLAYFE LQNQFYTTQE LQWEVIRHYS KQAIKQMYVL VLGLDVLGNP
     FGFFRDLSEG VEAFFYEPYQ GAIQGPEEFV EGMALGVKAL VGGAVGGLAG AASRITGAMA
     KGVAAITMDE EYQQKRREAM NKQPSGIREG ITRGGKGLVS GFVSGITGIV TKPIKGAQKE
     GAAGFFKGVG KGLVGAVTRP TGGIIDMASS TFQGIKKATD SSDDVESLRP PRFIHEDGVI
     RPYRMREGAG SQMLQKIENG RFAKCKYFAH AMVNSSDLLM VMKSGVLFVT RGTFGQLTCE
     WQYSFDEFTK EPFIVSGRRL RIEAKERVKS VFHAKEFGKI INFRTPEEAK WILCKLEEVR
     DAQTKT
//
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