GenomeNet

Database: UniProt
Entry: F6X517_HORSE
LinkDB: F6X517_HORSE
Original site: F6X517_HORSE 
ID   F6X517_HORSE            Unreviewed;      3100 AA.
AC   F6X517;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   07-OCT-2020, entry version 60.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSECAP00000021627};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSECAP00000021627,
GN   ECO:0000313|VGNC:VGNC:16394};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021627, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000021627, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021627,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000021627}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021627};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   PaxDb; F6X517; -.
DR   PRIDE; F6X517; -.
DR   Ensembl; ENSECAT00000025966; ENSECAP00000021627; ENSECAG00000024127.
DR   VGNC; VGNC:16394; CENPF.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; F6X517; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000002281; Chromosome 5.
DR   Bgee; ENSECAG00000024127; Expressed in inner cell mass and 16 other tissues.
DR   ExpressionAtlas; F6X517; baseline.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          1..305
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1889..2031
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2127..2266
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2309..2448
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2967..3009
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          208..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          470..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1513..1532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1664..1683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2887..3067
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          278..333
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          341..404
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          416..464
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          503..613
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          621..697
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          716..771
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          837..864
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          897..987
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1027..1082
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1087..1107
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1116..1150
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1194..1242
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1281..1315
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1334..1354
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1392..1412
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1544..1614
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1619..1641
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1787..1849
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1886..1906
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1956..1990
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2005..2095
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2103..2281
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2292..2312
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2320..2463
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2471..2491
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2506..2543
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2551..2606
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2632..2680
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2685..2705
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2714..2821
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2832..2859
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2867..2887
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        208..260
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..491
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1513..1530
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2887..2928
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2935..2950
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2951..2980
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2995..3009
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3032..3067
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3100 AA;  355254 MW;  15180A479B35AF86 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGTNLKRENQ SLMEICENLE KTKQKIAHDL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ TAQSADVSLN PCNTPQKIFA TPLTPSHYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKVSQAIPQS TMNHRDIARH QASSSVFSWQ QEQTPSRLSS SAQKTPIGRD
     FSASHFSGEV TPSRSTLKMG KRDANGSFCE DSSNSYLLDQ LKAQNQELRS KISELELRLQ
     GQEKEMKGQV NKFQELQLQL ERAKVELIEK EKVSNKSRDE LVRTTAQYDQ ASTKCTALEQ
     KLKKLTEDLS CQRQNADSAK RSLEQKIREK EKEFQEELSR QQRSFHTLDQ ECTQMKAKLT
     QELQQAKNMH NILQAELDKG TSAKHQLEKN LEEFKQKFSR TEQAFQASQI KENELRRSSE
     EMKKENSLLK SQSEQRAREV CHLEEELKKA KQCLSQSQNL AEEMKAKTTS QETMLRDLQE
     KINQQENSLT LEKLKLALAD LEKQRDCSQD LLKKREHHIE QLNDKLSKTE RESEALLTAL
     ELKKKECEEL KEEKTLFSRC KSENEQLLSQ MKSEKESLQS KVNHLETCLK TQQIKSHEYN
     ERVRTLEMER ENLNVEIRNL RNTIDSKTVE VETQKQAYVE LHQKAEFSDQ KHRKEMENMC
     LKVSQLTGQV EDLEHKLQLL SSEIMDKDQR YQDLRAECES LRDQLKSKDS SLVTNEAHHR
     SLLAFEQQSA MSNSFVNIIG EQESVPSERS ECPLKVDQSP KTSSVLQHRV VSLEFSLESQ
     KQMNSDLQKQ CEELVQIRGE IEENLIKAEQ MHQSFVAETS QRISKLQEDT SVHQNVVAET
     LVALEDKERE LQLLNEKLET EQAETQELKK SNHLLQEALK ELQLLSETLS SEKKEMSSVI
     SLNKREIEEL TQENGTLKEI NAALNQEKIN LLQKSESFSN CIDERDRSIS ELANQYQQER
     LILLQKCEET GNAFEDLNEK YKAAQEKNSK LESLLNECTS VCENKKNELE QLKEAFAREH
     QAFVTKLALA EERNQNLILE LGAVQQDLRS EITDIQNNSK SEADGLKQEI VTLKEEQSKM
     QQEVNALLQE NEHLIKLMKT EHEHQNLELE PARDSVKERE SEINRCDLQL PMDLEVEDTS
     LDSYKAQLAQ LEAKIRNMEL KLQESEEEKE CLQRELQTIR GELQTGSLQQ VTQSQEVRGL
     KDTEEQYISV LHELSTSQND NAHLQCSLQT AMNKLNELEK LCEVLRVEKF ELISELNDSR
     SECITATSKM AGEVEKLVNE VKMLNDENDL LQGEFVKEMP EGEFGEQQNE QKSVAVNPLD
     DGDFCEPLTL SNKEVQMHFA ELQEKFSSLQ SEHKILHDQH CQMSAKMSQL QSYVDMLKAE
     NSVLSTSLRN SQGDLVKEEM PGPREGRFLS LSFSCVTDSS SITSLGESSF YKELLEHTGE
     ASLLNNLEGD VSANRSPAEE ASSSSLEEEV LTKTDIPPAP ARTIEELETL CQMYRQSLQK
     LEEKMESQGI MKNKEIEELE QLLSCERKEL DCLREQYLSE NEQWQQKLTS VTMEMESKLA
     AEKKQTEQLS LELEVARLQL QGLDLSSRSL LGADVEDVIR DGNDSCDIKE SEENTSETRA
     RTPKDDIHQI GDKADQQDLS LEVEKITETG AVNLTGEWSR EQSPDTSHET PVEDKTLGCS
     ECVSELPPSG PNALVPMDVL ENQVTIQNLQ LQVKETSDEN LRLLHVIEER DKKVESLLNE
     LKELDSKLDL QKVQLTTKVE TCLELEKTVE ELKKEKSDLS EKLESFSCDN QKLHQRVESL
     EGVSSNLEVG TEKSSHEIIE DNVANVNNWR ERFFDAENEL KRIKSEKSSI ELHALSVEAD
     LERVQTEKLY LEKDNENKQN VITCLEEELS VVTSERNRLH GELDTLSKEN KELDQASEKM
     KEKVLELESR QGECLQHLDV VGAEVREKTQ LLQTLSSEVS ELLEDKGHLQ EQLQSLEKDS
     QTLSLVKSEL ENQIGQLSEE KESLVKESES LQTKLNELEH EKLDVAKALE AALMEKGEVA
     VRLSSTQEEV HQLRKGIEKL RVRIEADEKK QLHALEKLKE SERKNDSLQD KVENLERELQ
     MSEENQELVI LDAENCRAEA ETLKTQIELM TESLKVLEGD LTTVRSEKEN LMKELQEKQG
     QVSELDTLVS SFKNLLEEKE QEKIQMKEQS KAAVEMLQTE LKELNEEVAA LCDDQETWKA
     KEPSPDSAAL GVQQLRTSIE KVKVLLEADE KKQLHTLGEL KESRHHVDLL KDRVENLERE
     LEISKEKQER VRLEAENSKA EVVTLKVKIE EMAQSLRDLE LDLGNIRSEK ENLTKELQKE
     QGRVSELEVL NCSFENLLQE KEQEKVEMKE ESKIAVEMLQ TQLKELNEKV AALCNDQEIF
     KAKEQNLSSQ VDSLEHERSQ LLQGLDEAKS NYIILQSSVN GLVQEVEGGK QKLEKKDEEI
     SILKNQLQDQ EQLLSKLSQV EGEQQLCKNQ KIELGNLVVE LEQKIQGLQS KNDTLQDTLD
     MLQNSYKDLE KELELAKMEK MSFVEQVNTM TAKETELQRE MHEMVRERTE LKEGFTGEKQ
     RLREELNLMS EEIKSSKGQL KELMLENSEL KKSLDCAHKD QMEKHEKMRE EIAGYHLRLQ
     DAEKKHQALL LDTNKQYEME IQTYQEKLTS KEECLSSQKA EMDLLKSSKE ELSNSLKATT
     EILEELKKAK MDNLKHANQL KKENERAQGK IKLLIKSCKQ LEAEKEMLQK ELSRLEAAQE
     KQKTGTVVDA NVDELMTEMK ELKETLEEKN KEADEYLEKY CSLLISHEKL EKDKEMLETQ
     VARLSSQQSK LNLPSSPLLN SVVPGSSPAP SVTEKKLPSG QNKASGKRQR SSGIRENGEG
     TTPSTPETFS KKSRKAVKSG IHPAEDAEYA EFEPEGLPEV VKKGFADIPT GKTSPYVLRR
     TTMATRTSPR LAAQKLAPSP LSLDKENHAE TSKPTAGGSR SQKVKAAQQS PADSGSASRE
     PSTKSLSSCG LEYLDFVNWK RENGLNGDLA ELKVLPPECV
//
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