ID F6X625_MACMU Unreviewed; 755 AA.
AC F6X625;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=LSS {ECO:0000313|Ensembl:ENSMMUP00000029398.4,
GN ECO:0000313|VGNC:VGNC:74451};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029398.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000029398.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029398.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR AlphaFoldDB; F6X625; -.
DR SMR; F6X625; -.
DR STRING; 9544.ENSMMUP00000029398; -.
DR PaxDb; 9544-ENSMMUP00000029398; -.
DR Ensembl; ENSMMUT00000031417.4; ENSMMUP00000029398.4; ENSMMUG00000022329.4.
DR VEuPathDB; HostDB:ENSMMUG00000022329; -.
DR VGNC; VGNC:74451; LSS.
DR eggNOG; KOG0497; Eukaryota.
DR GeneTree; ENSGT00390000011570; -.
DR HOGENOM; CLU_009074_2_1_1; -.
DR InParanoid; F6X625; -.
DR OMA; CWARQTI; -.
DR TreeFam; TF300406; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000022329; Expressed in ileum and 21 other cell types or tissues.
DR ExpressionAtlas; F6X625; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0000250; F:lanosterol synthase activity; IBA:GO_Central.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 84..325
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 384..691
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 755 AA; 85878 MW; D867559A85E0F953 CRC64;
MTEGTCLRRR GGPYKTEPAT DLGRWRLSCE RGRQTWTYLQ DERAGRAQTG LEAHALGLDT
KNYFKDLPKA HTACEGALNG MTFYVGLQAE DGHWTGDYGG PLFLLPGLLI TCHVARIPLP
AGYREEIVRY LRSVQLPDGG WGLHIEDKST VFGTALNYVS LRILGVGPDD PDLVRARNIL
HKKGGAVAIP SWGKFWLAVL NVYSWEGLNT LFPEMWLFPD WAPAHPSTLW CHCRQVYLPM
SYCYAIRLSA TEDPLVQSLR QELYVEDFAS IDWLAQRNNV APDELYTPHS WLLHVVYALL
NLYERHHSAH LRQRAVQKLY EHIVADDRFT KSISIGPISK TINMLVRWYV DGPASTAFQE
HVSRIPDYLW MGLDGMKMQG TNGSQIWDTA FAIQALLEAG GHHRPEFSSC LQKAHEFLRL
SQVPDNPPDY QKYYRQMRKG GFSFSTLDCG WIVADCTAEA LKAVLLLQEK CPYVTEHIPR
ERLCDAVAVL LSMRNPDGGF ATYETKRGGH LLELLNPSEV FGDIMIDYTY VECTSAVMQA
LKYFHKHFPD HRAAEIRETL TQGLEFCRRQ QRADGSWEGS WGVCFTYGTW FGLEAFACMG
QTYRDGTACA EVSRACDFLL SRQMADGGWG EDFESCEERR YVQSAQSQIH NTCWALMGLM
AVRHPDIEAQ ERGIRCLLEK QLPNGDWPQV RRQGPERTRP STDLQCVRLF PRPPALCPFW
GKHLRGLQQV LCHLLHELQE CLPHLDPRAL LPAVP
//
