ID F6X6N4_XENTR Unreviewed; 775 AA.
AC F6X6N4; A0A5S6KS63;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=WD repeat domain-containing protein 83 {ECO:0000313|Ensembl:ENSXETP00000012334};
GN Name=wdr83 {ECO:0000313|Ensembl:ENSXETP00000012334};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000012334};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000012334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000012334};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000012334}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2019) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; F6X6N4; -.
DR STRING; 8364.ENSXETP00000019011; -.
DR PaxDb; 8364-ENSXETP00000006072; -.
DR Ensembl; ENSXETT00000012334; ENSXETP00000012334; ENSXETG00000005598.
DR AGR; Xenbase:XB-GENE-922905; -.
DR Xenbase; XB-GENE-969395; wdr83.
DR eggNOG; KOG3594; Eukaryota.
DR HOGENOM; CLU_005284_3_1_1; -.
DR Bgee; ENSXETG00000005598; Expressed in neurula embryo and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF311; CADHERIN-22; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..775
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169655"
FT TRANSMEM 593..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..139
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 140..248
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 249..363
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 370..466
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 466..593
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 775 AA; 85374 MW; 1CAADF0E01A0A644 CRC64;
MIVHLILVPL CIVLLTPVPN SLSQYCMSGR VKRGWVWNQF FVVEEYTGTE PLYVGKIHSD
SDEGDGSIKY TISGEGAGSI FIIDELTGDI HAMERLDREH KTFYTLRAQA RDRHTDRLLE
PESEFIIKVQ DINDSEPRFL QVPYIGSVPE LSPVGTSVMV VSAWDADDPA YGSSARVVYS
VLDGEKHFTV DSKTGVIRTA VSDLDRESQD RYDLVIQATD MAGQLGGLSG STTVTIVITD
VNDNPPRFPQ KLYQFSVAES SPPGSVIGRV KAEDADVGEN TDMFYQIQQQ EMGAMFKVST
DSITQEAVLS IIKSLDFETQ KEHSLVLEAQ NRFVDPRFAD LGTFRDQAII KVTVLDVDEP
PKFHPLDGII EVQEDAHIGS VIGAITAIDP DKANNPISYT LDRNSDDGIF EIDVESGEIR
ITKPLDRETS GWHNLTVQAH ETDPLKVSFL SLRIRILDVN DNPPELATPH ESSVCEDALP
GQLIQTISVV DRDEPMGGHR FYFRLAPEST AEHHFTLLNV KDNTASVHTH RMPFDRREQD
MFILPILVVD SGTPALSSTG TLTIRVCGCD SSGTVQSCNT TAYVMAGSLS PGALIALLVC
VLILVVLILL ILALKRHHQG HLTSEEDEDM RDNVIKYNDE GGGEQDTEAY DMSALRSLYN
FSDGSEAGGD SSLASQRHPL PQWFPGAELD FSLFRDYISR KVRLADQDST VPPYDSFQTY
AFEGSGSSAA SLSSISSWST GSQQDLSQLG SWGPRFRQLA ALYAGHRGQE ESPGS
//
