ID F6X749_ORNAN Unreviewed; 319 AA.
AC F6X749;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Apolipoprotein E {ECO:0000256|ARBA:ARBA00019891};
GN Name=APOE {ECO:0000313|Ensembl:ENSOANP00000022814.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022814.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000022814.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022814.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000022814.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022814.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body
CC {ECO:0000256|ARBA:ARBA00004559}. Extracellular vesicle
CC {ECO:0000256|ARBA:ARBA00034305}. Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR AlphaFoldDB; F6X749; -.
DR STRING; 9258.ENSOANP00000022814; -.
DR Ensembl; ENSOANT00000022818.2; ENSOANP00000022814.2; ENSOANG00000014474.2.
DR eggNOG; ENOG502QVD6; Eukaryota.
DR GeneTree; ENSGT00950000182929; -.
DR InParanoid; F6X749; -.
DR OMA; GHMTDAR; -.
DR OrthoDB; 4591103at2759; -.
DR TreeFam; TF334458; -.
DR Proteomes; UP000002279; Chromosome 5.
DR Bgee; ENSOANG00000014474; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0005771; C:multivesicular body; IEA:UniProtKB-SubCell.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0001540; F:amyloid-beta binding; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IBA:GO_Central.
DR GO; GO:0070326; F:very-low-density lipoprotein particle receptor binding; IBA:GO_Central.
DR GO; GO:0006707; P:cholesterol catabolic process; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042159; P:lipoprotein catabolic process; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:1900221; P:regulation of amyloid-beta clearance; IBA:GO_Central.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF2; APOLIPOPROTEIN E; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Chylomicron {ECO:0000256|ARBA:ARBA00022513};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW HDL {ECO:0000256|ARBA:ARBA00022850};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW VLDL {ECO:0000256|ARBA:ARBA00023313}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..319
FT /note="Apolipoprotein E"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027945509"
FT COILED 69..166
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 245..289
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 319 AA; 36679 MW; A17A0B9174DCD5BD CRC64;
MKLLWALFAV ALLAGCQADP LPLDQDLGLG AGNTQQPWEE TVERFWSYVV QVQNMAYDMH
DKAVNSQINK EINSLLEDTA TEFNALKEQL EPAVEDTRAR VHKELTAVVD RLQGDLQEAK
ERVTQYETEI QAMVGQNVEE LRSRTASQLR KLRKRITKDA EELRRRITVY GTGAREGMER
GVGVFRERLE PIGQRIQAKG QERVQVMGEL VSQQVKDLGS KVQGYGEQVK EKIQELQGQV
RGRLMKAGED TRDKLDDLKE KLEEMKEKVE QQANEVREQL EKIQEQLRSW FQPLVQDVQT
QWSNLLEKVQ GIKEPVPEE
//
