ID F6X923_CIOIN Unreviewed; 756 AA.
AC F6X923;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000010234.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000010234.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000010234.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; EAAA01000587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01000588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01000589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6X923; -.
DR STRING; 7719.ENSCINP00000010234; -.
DR Ensembl; ENSCINT00000010234.3; ENSCINP00000010234.3; ENSCING00000005489.3.
DR GeneTree; ENSGT00940000160454; -.
DR InParanoid; F6X923; -.
DR OMA; GRVNWAT; -.
DR TreeFam; TF313309; -.
DR Proteomes; UP000008144; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IBA:GO_Central.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF200; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 106..460
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 550..747
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 756 AA; 87675 MW; 053145C1ADA467FC CRC64;
EHLAMPSKQW MEFNDFLEGT FQARSFYPYW VSGNEYVYMN STAAINKVLL SGNKELMLII
TLYQLITSNT EKPFSWKISA DQNYLAIFYM KTDGYADYVR TFSCDIYNLL NGFLRTKQIL
PDFPTENLQK FQWSPTGHDF SYVYEFNVYL YKNTFLNHHQ ITNDGDEQMV FNGIADFLHW
IEITEDDSLM WWSPDSQYLA YATIKQTNVF AVEFSVYNNY QYPEMIRYPY PKPGTPIPTT
TVTVVDLSNL SLTQLKTLML FSRNFSSWSD GYYLNSVTWR GNHILSPTWK NRISNEAVVE
NCETPMFNCS YVSGMTSKST TGWLGHYKVA HIIPTNNDNV YITVRSLDGY QHITVFYVKE
NPKKVMTFIV TDTNEGYSPI YFYDEINDWI YFTSTELESK PGTALPRIRH IWRVKGSGSD
KNRSCISCHL NEIFPDRCNW VTPSFSRDGS YVVINCGGSG NAAPVSTLHM RNSSGDYEFV
GVVEGNEELI QTLNVVFLPN FMFFFLSHFS ARYPFQRLHL PPNFNESKKY PMLVQVYSGP
AYQQVRDRFE VSWKDYVSSA RDVIVMSFDG RGTGYRGDKI MHQVYKKLGQ YEPHDQIAAA
RKLATENQFI DQSKIAIWGW SYGGYELLNV IGEDADNVFK CGFAVAPVTK WEYYHTIWTE
KYMQQPKDNP DGYAKGSALQ GIENFRTHHF NLFHGTKDEN VHFQNSAQLS KYLIDGDVKF
GAFFAADDDH SMSRVNNGYR NIYKQLTRQM DLCFNL
//
