ID F6X9N5_HORSE Unreviewed; 443 AA.
AC F6X9N5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Mitochondrial rRNA methyltransferase 3 {ECO:0000313|Ensembl:ENSECAP00000021875.4};
GN Name=MRM3 {ECO:0000313|Ensembl:ENSECAP00000021875.4,
GN ECO:0000313|VGNC:VGNC:20315};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021875.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021875.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021875.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021875.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021875.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6X9N5; -.
DR Ensembl; ENSECAT00000026239.4; ENSECAP00000021875.4; ENSECAG00000024378.4.
DR VGNC; VGNC:20315; MRM3.
DR GeneTree; ENSGT00390000017317; -.
DR HOGENOM; CLU_021322_1_0_1; -.
DR TreeFam; TF323420; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000024378; Expressed in gluteus medius and 23 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0070039; F:rRNA (guanosine-2'-O-)-methyltransferase activity; IEA:Ensembl.
DR CDD; cd18106; SpoU-like_RNMTL1; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR43191; RRNA METHYLTRANSFERASE 3; 1.
DR PANTHER; PTHR43191:SF2; RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 124..195
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 65..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 49169 MW; DFF9CEA488048434 CRC64;
MAALVKGLGQ ATRPLLPVVQ SWDRDARRWV RALRRSPVKV VFPSGEVVER KLSPGKQPRK
GVFEAGRHEQ RLKQPLPVPP SQTPSTWEES GLRYDKALPG DKRLSSVMTI VKSRPFREKQ
GKILLEGRRL IADALKAGAV PKVFFFSRLD YIKELPTDKL KGVSLIKVKF EDIKDWSDLV
TPQGIMGIFA KPDHVKMTYP ETQLRHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL
TKGCVDAWEP KVLRAGMGAH FQVPIINNLD WETVPNYLPT DTRVYVADNC GLYAQAQTSN
KASDHGWVCD RQLSKLHKYE EEVDLETGAS KGWLPELEVQ SYDLDWTEAP AAVVIGGETH
GVSLESLQLA ENTGGKRLVI PVVPGVDSLN SAMAASILLF EGKRQLRRLC GYLFEDSLFR
KGGNSFKICS LTVHPSGKLY SFH
//
