ID F6XC52_HORSE Unreviewed; 1478 AA.
AC F6XC52;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
GN Name=DLC1 {ECO:0000313|Ensembl:ENSECAP00000002499.2,
GN ECO:0000313|VGNC:VGNC:17207};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002499.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002499.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002499.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002499.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002499.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR Ensembl; ENSECAT00000003541.4; ENSECAP00000002499.2; ENSECAG00000013988.4.
DR VGNC; VGNC:17207; DLC1.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_045266_0_0_1; -.
DR TreeFam; TF339092; -.
DR Proteomes; UP000002281; Chromosome 27.
DR Bgee; ENSECAG00000013988; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; F6XC52; baseline.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09591; SAM_DLC1; 1.
DR CDD; cd08908; START_STARD12-like; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1028..1234
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1264..1449
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 364..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1478 AA; 165477 MW; 63D65FE85DA89B43 CRC64;
MSAAIRKRSW EEHVTQWMGQ PFNSDSYNAA CHHGLVADSL QASMEKDATL NVDRKEKCVS
LPDCCPGSEL RDFPGRPMGH ISKDVDENDS HEGEDQFFSL EASTETLVHI SDEDTDSDLY
LTDDKQILTT QEHKTSDQCS VRGAGSLVKT LSIMESNEDS YNSWGTAGGA DLVLVEEKGE
RKVVDIISKG LELCNDINLS EIKDASKIDA CDSLNVKDIV PEKQLLNSAV IAQQRRKPDF
PKDEHERNTC SVVQEEFLAI PCTDRGLPLL KPDSGNCLLQ PLSCPRGMLA ENGLEKSGFS
EHQNKSLPRV NSGDGMQCLH LKETLATQEP ADNQVRLRKR KDLESGSESG ADTISVNQTQ
INLSSNTEST DLPSSTAVAN SGTKPKSMAI PGISEKEKAE IEAKEACDWL RATGFPQYAQ
LYEDLLFPID ISLVKREHDF LDRDAIEALC RRLNTLNKCA MMKLEISPHR KRSEDSDEDE
PCAISGKWTF QRDSKRWSRL EEFDVFFPKQ DPVPGSPDDP HLKNATSHES MLTDLSERQE
VASVRSLSST SSLPTHAPHS GDAVTPRTNS VISVCSSGNF VGNDDSFCSL PSPKELSSFS
FSMKGHEKNT KSKTHSLLKR MESLKLKGSH HSKHKAPSKL GLIISGPILQ EGMDEEKLKQ
LNCVEISALN GNHINVPMVR KRSVSNSTQT SSSSSQSETS SAVSTPSPVT RTRSLSACNK
RVGMYLEGFD PFNQSTFNNV MEQNFKNRES YPEDTVFYIP EDHKPGTFPK ALSNGSFSPS
GNNSSVNWRT GSFHGPGHIS LRRESSSDSP KELKRRNSSS SMSSRLSIYD NVPGSILYSS
SGDLADLENE DIFPELDDIL YHVKGMQRIV NQWSEKFSDE GDSDSALDSV SPCPSSPKQI
HLDVDHDRGT PSDLDSTGNS LNEPEEPADI PERRDSGVGA SLTRSNRHRL RWHSFQSSHR
PSLNSVSLQI NCQSVAQMNL LQKYSLLKLT ALLEKYTPSN KHGFSWAVPK FMKRIKVPDY
KDRNVFGVPL TINVQRTGQP LPQSIQQAMR YLRNHCLDQV GLFRKSGVKS RIQALRQMNE
SAIDCVNYEG QSAYDVADML KQYFRDLPEP LMTNKLSETF LQIYQYVPKD QRLQAIKAAI
MLLPDENREV LQTLLYFLSD VTAAVKENQM TPTNLAVCLA PSLFHLNTLK RENSSPRVMQ
RKQSLGKPDQ KDLNENLAAT QGLAHMIAEC KKLFQVPEEM SRCRNSYTEQ ELKPLTLEAL
GRLCNDESAD YQHFLQDCVD SLFKEVKDKF KGWVSYSTSE QAELSYKKVS EGPPLRLWRA
TIEVPAVPED ILKRLLKEQH LWDVDMLDSK VIEILDSQTE IYQYVQNSMA PHPARDYVVL
RTWRTNLPKG ACALLLTSVD HDRAPVVGVR VNVLLSRYLI EPCGSGKSKL TYMCRADLRG
HMPEWYTKSF GHLCAAEVVK IRDSFCNQNT ETKDTKSR
//
