ID F6XCK6_HORSE Unreviewed; 433 AA.
AC F6XCK6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Mitochondrial calcium uptake 2 {ECO:0000313|Ensembl:ENSECAP00000014080.2};
GN Name=MICU2 {ECO:0000313|Ensembl:ENSECAP00000014080.2,
GN ECO:0000313|VGNC:VGNC:20173};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014080.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000014080.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014080.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000014080.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014080.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6XCK6; -.
DR SMR; F6XCK6; -.
DR STRING; 9796.ENSECAP00000014080; -.
DR PaxDb; 9796-ENSECAP00000014080; -.
DR Ensembl; ENSECAT00000017337.3; ENSECAP00000014080.2; ENSECAG00000016494.3.
DR VGNC; VGNC:20173; MICU2.
DR GeneTree; ENSGT00950000183079; -.
DR HOGENOM; CLU_027103_0_1_1; -.
DR InParanoid; F6XCK6; -.
DR OMA; LKYQEFH; -.
DR OrthoDB; 1020411at2759; -.
DR TreeFam; TF320374; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000016494; Expressed in gluteus medius and 23 other cell types or tissues.
DR ExpressionAtlas; F6XCK6; baseline.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
DR GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR CDD; cd16174; EFh_MICU2; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF3; CALCIUM UPTAKE PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 361..396
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 433 AA; 49492 MW; 59ED25C81209F9A8 CRC64;
MAAAAARGSR LAAWGGRLRR GVAAGRRALP SPGPVAAAVA GVALAGAGVA WYHGRATVAA
PEGSLTVFAQ KNIDYGEMMG KLSLRKQRFM QFSSLEYEGE YYMTPRDFLF SVMFEQMERK
TSVRKLTKKD IEDVLAGIQK AGCGSTFFRD LGDKGLISYT EYLFLLTILT KPHTGFHVAF
KMLDADGDEM VEKKEFFKLQ KIISKQDDLK MTVANETECQ EPRVKESEIN TTLQIRFFGK
RGERKLHYRE FRRFMENLQA EIQEMEFLQF SKGLSFMRKE DFAEWLLFFT NTENKDIYWK
NVREKLSAGE SISLDEFKSF CHFTTHLEDF AIAMQMFSLA HRPVRLAEFK RAVKVATGQE
LSNNILDTVF KIFDLDGDEC LSHGEFLGVL KNRMHRGLWV PQQLSIQEYW KCVKKESIKG
VKEVWKQAGK GLV
//
