ID F6XEA3_HORSE Unreviewed; 1054 AA.
AC F6XEA3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Zinc finger and BTB domain containing 11 {ECO:0000313|Ensembl:ENSECAP00000021868.2};
GN Name=ZBTB11 {ECO:0000313|Ensembl:ENSECAP00000021868.2,
GN ECO:0000313|VGNC:VGNC:25132};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021868.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021868.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021868.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021868.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021868.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6XEA3; -.
DR STRING; 9796.ENSECAP00000021868; -.
DR PaxDb; 9796-ENSECAP00000021868; -.
DR Ensembl; ENSECAT00000026231.3; ENSECAP00000021868.2; ENSECAG00000024373.3.
DR VGNC; VGNC:25132; ZBTB11.
DR GeneTree; ENSGT00900000141090; -.
DR HOGENOM; CLU_010706_0_0_1; -.
DR InParanoid; F6XEA3; -.
DR OMA; RYAFIMH; -.
DR OrthoDB; 4140598at2759; -.
DR TreeFam; TF332263; -.
DR Proteomes; UP000002281; Chromosome 19.
DR Bgee; ENSECAG00000024373; Expressed in spinal cord and 23 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd18202; BTB_POZ_ZBTB11; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 10.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR048060; ZBTB11_BTB_POZ.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394:SF29; GM08392P; 1.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR Pfam; PF13912; zf-C2H2_6; 4.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 214..282
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 570..597
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 598..625
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 652..679
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 680..707
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 708..735
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 736..763
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 767..794
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 795..822
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 823..852
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 859..886
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 887..914
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 915..943
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 140..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1054 AA; 119483 MW; 7370363E0B136CD1 CRC64;
MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ RRRRHRRTFA
ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHDLSKTY WWRGILKQVK DYIKQCSKCQ
EKLDRSRPIS DTSEMLEELG LDLESGEESN ESEDDLSNFT SPPTTASKPA KKKPVSKHEL
VFVDTKGVVK RSSPKHCQAV LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR
DLFIEKGAVS SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFYSMADVAV LARHLFMSEV
LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLTEQNGAT APPVASNEGT TTTLSTELGD
CEIVLLVNGD LPEAEQNGEL GQQPEPQVSS EAEAALSPAG CITDSHPEVH SVDLVTKNSQ
TELETLNSRE DSTVSNVHPK ASKENVISSS PENSDMGNDT SAEDICAEDI TEPRQNSGQS
LNDEENPVAP TAKPDLGPDN DTYRSRLRQR SVNEGGYIRL HKGMEKKLQK RKALPKSAVQ
QVAQKLVQRG KKMKQPKRDA KENTEEEASH KCGECGMVFQ RRYALIMHTL KHERARDYKC
PLCKKQFQYR ASLRAHLIRH ARKDSPASSS SNSTSNEASG TSSEKGRTKR EFICSICGRT
LPKLYSLRIH MLKHTGVKPH ACQVCGKTFI YKHGLKLHQS LHQSQKQFQC ELCVKSFVTK
RSLQEHMSIH TGESKYLCSV CGKSFHRGSG LSKHLKKHQP KPEVRGYHCT QCEKSFFEAR
DLRQHMNKHL GVKPFQCQFC DKCYSWKKDW YSHVKSHSVT EPYRCNICGK EFYEKALFRR
HVKKATHGKK GRAKQNLERV CERCGRKFTQ LREYRRHMNN HEGVKPFECL TCGVSWADAR
SLKRHVRTHT GERPYVCPVC SEAYIDARTL RKHMTKFHRD YVPCKIMLEK DTLQFHNQGT
QVEHAVSILT ADMQEQESSV PQELETVVVT GETMEALEAV AATEECPSVS TLSDQSIMQV
VNYVLAQQQG QKLSEVAEAI QTVEVEVAHI SEAE
//
