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Database: UniProt
Entry: F6XF06_ORNAN
LinkDB: F6XF06_ORNAN
Original site: F6XF06_ORNAN 
ID   F6XF06_ORNAN            Unreviewed;      2798 AA.
AC   F6XF06;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOANP00000015098};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000015098, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000015098}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000015098};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   STRING; 9258.ENSOANP00000015098; -.
DR   Ensembl; ENSOANT00000015101; ENSOANP00000015098; ENSOANG00000009508.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   InParanoid; F6XF06; -.
DR   OMA; ICHAREL; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000009508; Expressed in 2 organ(s), highest expression level in cerebellum.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      113    168       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      175    220       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      228    282       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      356    413       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      579    809       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1040   1222       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      472    492       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2798 AA;  310253 MW;  75002B3AC68355F4 CRC64;
     SADLSVGLDK IISALHTEDE VVLQCVANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCICHFVL QQSLSVRALQ EMLANSGEDP GDGVALSTPP LKKGCGATQG GSRRTLLYGH
     ALLLRHAFSG MYLTCLTTSR SQTDKLAFDV GLREHAVGEA CWWTIHPTSK QRSEGEKVRI
     GDDLILVSVS SERYLHLSVS NGVIGVDAAF LQTLWNVHPT CSAGGIVEGY LLGGHVVRLF
     HGHDECLTVP LADQSDSQHR RVFYEAGGAG SRARSLWTVE PLRISWSGGS IRWGQAFRLR
     HITSGQYLAL AEDQGLVLQD RSRADTASTA FCFRPSNETK GKPDGSHKAE PEGMGVAEIK
     YGDSVCFVQH VASGLWVTFK AQDMKTSRLG PLRRKVILHQ EGHTDDGLTL QRCQREESQA
     SRIIRNTTSL FSQFLSGHNR AAAPIAPPPD AVLQTLRDLI AYFRPPAEGV QHEDKQSRLR
     ALRNRQNLFK EEGMLTLVLN CIDRLNIYNS ATHFAGFARE ESSAAWKEIL NLFYELLAAL
     IRGNRNNCAQ FSRRLDWLIG KLDRLESSSG ILEVVHCILT ESPEALTLIT ESHIKSIISL
     LDKHGRNPKV LVVLCSLCLC NGVAVRANQN LICDHLLPRR DLLLQTRLVN DVTSIRPNIF
     LGTSEGSAQY RRWYFELILD QVQPFLTAEP THLRVGWASS AGYAPYPGGG EGWGGNGVGD
     DLYSYGFDGL HLWSGRISRA VASANQHLLK SDDVVSCCLD LAAPSVSFRI NGQPVQGMFE
     GFGTTGYFFP VASFSAGVKI RFLLGGRHGD FKFLPPSGYA PCAEALLPGE RMRLEPVKEY
     KRDRAGVRDL LGTSHFLSQA AFTPRPIDTS RISLPPHLEK VRDRLAENIH ELWAVSKTEL
     GWTFGKVRDD NKKQHPCLVE FSKLPDTEKN YNLQMSTETL KTLLALGCHV VHANLAAEED
     LKKLKLPKNY VMSGGYKPAP LDLSEVKLLP TQEALVDKLA ENAHNIWAKD RIEQGWTYGT
     QQDLKNKRNP RLVPYALLDE RTKKSGRDSL REAVRSIVGY GYSIEPSDQE LPADQNVEKV
     SVDKIRFFRV ERSYAVKTGR WYFEFEAVTG GDMRVGWARP GCRPDVELGA DDQAFVFEGN
     RGQRWHRGRS SFGRCWKAGD VVGCLVNLDD ASMLFTLNGD LLITSLGSEL AFADYDIDHG
     FVPICSLGLA QIGRMNLGMD ASTFKFYTTC GLQEGFQPFA VNMNRDVAMW FSKRLPTFVN
     VPGNHPHVEV TRVDGTIDSP PCLKVTHKTF GTQSSGPGML YCRLSMPVEC RPALVDGDLF
     LKSGWDYRRD LPAWCPRGRH REGVRGSPGQ LKAKKPSLGP PQPWTVPPTL PQDRPPQAGA
     ETGRTQFPGG TLSCRCSITV LRPHHSALFP LPQCSFSVRI FAGQDPSCVW VGWVTPDYHF
     YSDKFDLHQS CSVTVTLGDE RGRVHESVRR SNCYMVCGGE TLAAPQRPVR SNADLKIGCV
     LDLASGILSF SANGTELTTC YQVEPHTKVF PAVFLQPTST ALFQFELGRL KGAMPLSAAI
     FPSEERNPMP QCPPRLDVQT LRPVLWSRMP SRFLKVETER VSERQGWAVR CLEPLQMMAL
     HIPEENRCVD VLELCEQEDL LLFHYHTLRL YGAVCALGNG RAAAALCGHV DLPQLFHAID
     DQYLPGLLRA GFFDLLISAY LDQAKEANLA MKNEFIIPIA PATRQIRLYP GPSERHGLPG
     VGPGSCLRPG SRLGPAPRAG VPGSVSTGGG ARGTSPGVPL RALKERALAM LTEAVRGSGA
     HVRDPVGGSV EFEFVPVLKL VRALLIMGEF SGDNVRQILL LVDPTVFGEP QAETGAGARK
     EAEAREEGKA VEAGEEAGQE PRGPAKGLLQ MRLPESVKLQ MCELLSHFCD CELQHRVEAT
     VAFGDGYVSR LQVNQKQRYS ELMQALNMSA ALTAKKTREF RSPPQEQINI LLNFQLGEDC
     PCPPELREDL YDFHEDLLSH CGVPLGKEEE EEEDTAWMHR LWGLVGKIKR RSGPQEEKMG
     EEEERSPTSL KELISQTMVR WAQEERIRDP ELVRAMFHLL RRQYDSVGEL LRALRKTYAI
     SQASVEDAAH LLAALGQIRS LLSVTMGPEE ELLMINGLGD IMNNKVFYQH PNLMRVLGMH
     ETVMEVMVNV LGGHKAQQMA FPRMVASCCR FLCYFCRISR QNQKAMFEHL SYLLENSSVG
     LASPSLRGST PLDVAASSVM DNNELALGLE EPDLDKVVTY LAGCGLQSCP LLLARGYPDL
     GWNPIEGERY LSFLRFAVFV NGESVEENAS VVVKLLIRRP ECFGPALRGE GGAGLLAAVQ
     GAIKISETPA LDLPSQGPRS RGEGGEVAAT GEEEREEEEI VHMGYTILSF YSALIDLLGR
     CAPETHLIQT GKGEAIRIRS ILRSLVPTED LVGIISLRLK LPTLDKDGLV TEPDMSASFC
     PEHKAPMVLF LDRVYGVEDQ NFLLHLLEVG FLPDLRASAS LDTASLSTTE AALALNRYLC
     SAVLPLLTRC APLFSGTEHC TSLMDSTLQT IYRLSKGRSL TKAQRDTVEE CLLAVCNHLR
     PPMLQQLLRR LVFDVPLLSE FCRMPLKLLT NHYEQCWKYY CLPAGGGGCD FAAEEELHLT
     EKLFWGIFDS LSHKKFEPDL FRMALPCLSA IAGALPPDYT DTRAPATLLK QTSVDVDGNF
     DPKPIDTSNL TLPEKLETLV TKFAEHVHDR WAWDKSQSGW KYGLLLDENM KTLPLLRPFK
     TLSEKEKELY RWPARESLKS MLALGWTLER TREGEAMA
//
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