ID F6XKP3_HORSE Unreviewed; 703 AA.
AC F6XKP3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Sulfate anion transporter 1 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 1 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A1 {ECO:0000313|Ensembl:ENSECAP00000019522.2,
GN ECO:0000313|VGNC:VGNC:23121};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019522.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000019522.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019522.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000019522.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019522.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent sulfate anion transporter. Can transport
CC other anions including bicarbonate, thiosulfate and oxalate.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_014594163.1; XM_014738677.1.
DR AlphaFoldDB; F6XKP3; -.
DR SMR; F6XKP3; -.
DR STRING; 9796.ENSECAP00000019522; -.
DR PaxDb; 9796-ENSECAP00000019522; -.
DR Ensembl; ENSECAT00000023561.4; ENSECAP00000019522.2; ENSECAG00000022104.4.
DR GeneID; 102148919; -.
DR KEGG; ecb:102148919; -.
DR CTD; 10861; -.
DR VGNC; VGNC:23121; SLC26A1.
DR GeneTree; ENSGT01100000263544; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; F6XKP3; -.
DR OMA; EMFARNH; -.
DR OrthoDB; 1067648at2759; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000022104; Expressed in adult mammalian kidney and 18 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:Ensembl.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF31; SULFATE ANION TRANSPORTER 1; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|RuleBase:RU362052};
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Ion transport {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 66..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 118..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 347..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 378..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 414..432
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 476..501
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 537..689
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 574..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 75036 MW; 62C03523498554F6 CRC64;
MEVPPEQSWG PVLVRRQPPA TQGLCETLKA RLRRSCTCSM QGAKALVQDL LPATRWLRGY
RLREDLVGDV MSGLVIGIIL VPQAIAYSLL AGLQPIYSLY TSFFANLIYF LMGTSRHVSV
GIFSLLCLMV GQVVDRELLL AGFDPAQDGP GPRHNSSTFN ASAAMLALGL QNCGRDCYAI
RVATALTLLA GIYQVFMGIL RLGFVSAYLS QPLLDGFAMG ASVTILTSQL RHLLGVRVPR
HQGPGMVVST WLSLLRSAGQ ANLCDVLTSA VCLAVLLAAK ELSDRCRHRL KVPLPTELLV
ILAATLASHL GQFHERFGSS VAGDIPTGFM APRVPDPGLM QRVALDAVPL AFVASAFSIS
LAEMFARSHG YSVRANQELL AVGCCNVLPA FFHCFATSAA LAKSLVKTAT GCRTQLSSVV
SAAVVLLVLL ALAPLFRDLQ RSVLACVIVV SLRGALRKVR DVPQLWQLSP ADALVWVATA
ATCVLVSTEA GLLVGVLLSL LSLAGRTQRP RAVLLARIGD SGFYEDAEEF EGLVPEPGVR
VFRFAGPLYY ANKDFFLKSL YSLTGLDAGR EAARRKQRGS GAGVSEEDPV EGKDLGPGSS
SAVLVPTAGS FHAVVIDCAP MLFLDAAGMA TLWDLRRDYG ALGITLLLAC CSPAVREALR
RGGFLGDDQG DTAEEAQLFH SVHSAVQAAQ ARHRERAAAD STL
//