ID F6XP14_HORSE Unreviewed; 428 AA.
AC F6XP14;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Leucine-rich repeat-containing protein 42 {ECO:0000256|ARBA:ARBA00014198};
GN Name=LRRC42 {ECO:0000313|Ensembl:ENSECAP00000002422.1,
GN ECO:0000313|VGNC:VGNC:19781};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002422.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002422.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002422.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002422.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002422.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LRRC42 family.
CC {ECO:0000256|ARBA:ARBA00009297}.
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DR RefSeq; XP_001488891.1; XM_001488841.5.
DR AlphaFoldDB; F6XP14; -.
DR STRING; 9796.ENSECAP00000002422; -.
DR PaxDb; 9796-ENSECAP00000002422; -.
DR Ensembl; ENSECAT00000003415.3; ENSECAP00000002422.1; ENSECAG00000002987.3.
DR VGNC; VGNC:19781; LRRC42.
DR GeneTree; ENSGT00390000002727; -.
DR HOGENOM; CLU_053705_0_0_1; -.
DR InParanoid; F6XP14; -.
DR OMA; FYGKTHR; -.
DR OrthoDB; 3083188at2759; -.
DR TreeFam; TF331102; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000002987; Expressed in retina and 23 other cell types or tissues.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR039631; LRRC42.
DR PANTHER; PTHR31994; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42; 1.
DR PANTHER; PTHR31994:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42; 1.
DR Pfam; PF13516; LRR_6; 3.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 386..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 48365 MW; 6C38905BB4125982 CRC64;
MSCYLNSENH LDPGPIYVRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG FSVELCMNRE
DDTAQKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS
AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VISEKLEEIK SFRELTCLDL
SCCKLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL
SCNPEITDAG IGYLFSFRKL NCLDISGTGI KDITAIKHKL QTHIGLVHSK VPLKEFDHSN
CKTEGWADQI VLQWERVTSE AVKLQETSEP RAAAQRFYGK RARTEAPGKC PLADTHMNSS
EKLQFYKEKA ADCHGPLLKC EAVLSQESKK SKKRVFEEPE KEQSNSSQSS KQKYVCLAVE
DWDLLNSY
//
