ID F6XQW2_HORSE Unreviewed; 748 AA.
AC F6XQW2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=BRCA1 associated RING domain 1 {ECO:0000313|Ensembl:ENSECAP00000002144.3};
GN Name=BARD1 {ECO:0000313|Ensembl:ENSECAP00000002144.3,
GN ECO:0000313|VGNC:VGNC:56539};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002144.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002144.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002144.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002144.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002144.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001488940.2; XM_001488890.4.
DR AlphaFoldDB; F6XQW2; -.
DR Ensembl; ENSECAT00000002994.3; ENSECAP00000002144.3; ENSECAG00000002113.4.
DR VGNC; VGNC:56539; BARD1.
DR GeneTree; ENSGT00940000156532; -.
DR HOGENOM; CLU_021642_0_0_1; -.
DR TreeFam; TF326440; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000002113; Expressed in bone marrow and 23 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd17720; BRCT_Bard1_rpt2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039503; BARD1_Znf-RING.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR PANTHER; PTHR24171:SF8; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF14835; zf-RING_6; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 398..430
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 431..463
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 464..496
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 539..624
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 638..748
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 152..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..301
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82872 MW; 794B8488F7BEA0F6 CRC64;
MRATNALQSR FSRVLGVEAG STSILREPVC LGGCEHIFCS NCVSDCIGTG CPVCYTPAWI
QDVKINRQLD SMIQLCSKLR HLLHGHELSD SKEDTPGKGL FNDAENKKNS IKMWFSPRSK
KVRYVVTKVS VQTQPQMIND ENSQQASMYE YVSPSPTGDV SERAKKASTR SRKKQKKKTL
AEINQEWNLE VEKEDGELDP KQECKEKLVS FCSQPSIIAS PQTNGEVDFL ASGSVTESES
FGSLTEVSLP LAEQIESPEI KSRDEVVTPE KNLCENYLSS KKSLPLGHSG KRGRRNRLSS
PISKRSRSSI LSTGGSFVEQ TVLSENLPLP GCSSPPSSKL KVDDALGSKN SNISDESLSL
SPGTPSALNS PSYRRMMTSP SAMKLSPNSL MAAKRNHRGE TLLHIASIKG DIPSVEYLLQ
NGSDPNVKDH AGWTPLHEAC NHGHLRVVEL LLQHKALVNT TGYQNDSPLH DAAKNGHVDI
VKLLLSYGAS RNAVNIFGLR PVDYADSENM KSLLLLPEKN ESSSTSRCSV MSTGQHRGGP
RVLIGSGLSS EQQKMLSELA AVLKAKKCTE FDSTVTHVIV PGDTIQSTLK YMLGILNGCW
ILKFEWVKVC LQRKEYEQEE KYEIPEGPQR GRLNREQLLP KLFDGCYFYF GGTFKHHPKD
NLIKLVTAAG GQILSRKPKP DSDVTQTINT VAYHAKPDSD QRLCTQYIIY EDLSNHRPEK
VRQGKVWMAP SSWFIDCVMS FELLPLDS
//
