ID F6XSC0_HORSE Unreviewed; 435 AA.
AC F6XSC0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Transmembrane protein 130 {ECO:0000313|Ensembl:ENSECAP00000007510.2};
GN Name=TMEM130 {ECO:0000313|Ensembl:ENSECAP00000007510.2,
GN ECO:0000313|VGNC:VGNC:24193};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007510.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007510.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007510.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007510.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007510.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6XSC0; -.
DR STRING; 9796.ENSECAP00000007510; -.
DR PaxDb; 9796-ENSECAP00000007510; -.
DR Ensembl; ENSECAT00000009813.4; ENSECAP00000007510.2; ENSECAG00000009541.4.
DR VGNC; VGNC:24193; TMEM130.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_767189_0_0_1; -.
DR InParanoid; F6XSC0; -.
DR OMA; AEWEQIG; -.
DR OrthoDB; 5400516at2759; -.
DR TreeFam; TF336431; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000009541; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR PANTHER; PTHR11861:SF10; TRANSMEMBRANE PROTEIN 130; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..435
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018626956"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..210
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 435 AA; 48183 MW; E4B99997A0A7FFE2 CRC64;
MAPALWPRLG RILWLACLLP LAPARAAAGL YELRLTTDGP ATTGAEVTIT ASLVASDNGS
LVLPADTHLY RFHWIHTPLL LTGKTDEAFS SSIRVVGSVP GDFPVSVWVT AADCWMCQPV
SKSLLVLPIT EFLVGNLVVT QNTSLPWPGS YLTKTILRVS FLLHDPSNFF KTASFLYSWD
FGDGTLLVTD DPMVYYNYSI VGTFTVKLKV VAEWEQATLD AGKGIMQKTG DFSASLKLQE
TLRGIQVLGP TLIQTFQKMT VTLNFLGSPP LTVCWRLKPE CLPLEEGECH PVSVASTAYN
LTHTFRDPGD YCFSIRAENV ISKTHQYHRI QVWPSSIQPA VFAFPCATLI TMMLAFIMYM
TLRNAAQQKD MVEVADFDFS PMSDKNPEPP AGVRCCCQMC CTPFLLETPS EYLEVVRENH
GLLPPLYKSV KTYTV
//
