ID F6XTD1_MONDO Unreviewed; 1914 AA.
AC F6XTD1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Myosin XVIIIA {ECO:0000313|Ensembl:ENSMODP00000024115.4};
GN Name=MYO18A {ECO:0000313|Ensembl:ENSMODP00000024115.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000024115.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000024115.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000024115.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMODT00000024542.4; ENSMODP00000024115.4; ENSMODG00000019323.4.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000155768; -.
DR HOGENOM; CLU_000192_1_0_1; -.
DR TreeFam; TF339614; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000019323; Expressed in heart and 18 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 219..310
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 346..400
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 404..1179
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1699..1735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1243..1340
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 88..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1859..1877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 497..504
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1914 AA; 215376 MW; 0077DC86855D6E64 CRC64;
MFNLMKKDKD KDGSRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL
EISNPIPIKV ASSSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE SGRPSVLQRA
AKFGSLAKQN SQMIVKRFSF SQRSRDGSAS ETSTPSEHSA APSPQVEVRT LEGQLARQAG
SSVSWPGCRT RGPELVSKRF AADLRLPAVA PLLPPPPREL ELQRRPTGDF GFSLRRTTML
DRAPEGQAYR RVVHFAEPGA GTKDLALGLV PGDRLVEING QNVENKSRDE IVEMIRQSGD
HVRLKVQPIP ELSELSRSWL RSGLGQQREP TDAKTEEQIA AEEAWHETEK VWLLHQDGFT
LASQLKSEEL SLPEGKVRVK LDHDGTILDV DEGDVEKANA PSCERLEDLA SLVYLNESSV
LHTLRQRYGA SLLHTFAGPS LLILSPRGAP AMYSEKVIHM FKGCRREEMA PHIYTVAQTA
YRNMLMNRQD QSIVLLGSSG SGKTASCQHL VQYLATIAGT GGNKVFSVEK WQALYTVLEA
FGNSPTIMNG NATRFSQILS LDFDQAGQVA SASIQTMLLE KLRVARRPSN EATFNVFYYL
LACGDSTLRT ELHFNHLAEN NVFGIVPLSK PEEKQKAAQQ FSKLQAAMKV LGISPDEQKA
CWFILAAIYH LGAAGATKAG RKQFARHEWA QKAAYLLGCS LEELSSAIFK HQPKGSLQRS
TSFRQGPEES SPGDAAGSKL SALECVEGMA AGLYSELFTL LVSLVNRSLK SSQNSLCSMM
IVDTPGFQNP DLGGSTRGAS FEELCHNYTQ DRLQALFHER TFVQELERYK EENVELAFDD
LEPGAVDSVD AVDQASQQAL VRSLARPDEA RGLLWLLEEE AMVPGGTDEA LLERLFSYYG
PQDGDKKGQS PLLRSSKPHH FLLGHSHNTN WVEYNVEGWR NYAKQNPAMQ NAPRLLQDSQ
KKIISNLFVG RAGSAMVLSG SIAGLEGGSQ LALRRATSMR KTFATGVAAV KKKSLCIQIK
LQVDALIDTI RKSKLHFVHC FLPVAEGWAG EPRSASSRRV SSSSELDLPP GEHCETGLLP
LDIPLLRAQI RGSRLLDALR MYRQGYPDHM VFSEFRRRFD VLAPHLTKKH GRNYIVVDEK
RAVEELLESL DLEKSSCYMG LSRVFFRAGT LARLEEQRDE QTSKNLTLFQ AACRGYLARQ
HFQKRKVQDL AIRCVQKNIK KNQGVKDWPW WRLFTAVRPL VEVQLSEEQL RGKDEEIQQL
RGKLEKVEKE RNELRLNSDR LETRISELTS ELADERNTGE SASQLLDAEA AERLRAEKEM
KELQIQYDAL KKQTEAMEIE VMEARLIRAT ELNGEMDDDD SGGEWRLKYE RAVREVDFTK
KRLQQEFEDK LEAEQQSKRQ LERKLVDLQA DSDESQRTHQ QLKKKCQRLT AELQDTRLHL
EGQQVRNHEL EKKQRRFDSE LSQAHEETQR EKLQREKLHR EKDALLAEVF SLKQQMEEKD
MDIAGFTQKV VSLEAELQDI SSQESKDEAS LAKIKKQLRD LEAKTKDQEE ELDEQAGTIQ
MLEQAKLRLE MEMERIRQTH SKEIEGRDEE VEEARQSCQK KLKQMESQLE EEYEDKQKVL
REKRDLESRL NALSDQVGRR DLESEKRLRK DLKRTKALLA DAQIMLDHLK NSAPSKREIA
QLKNQVLGRD GSVSLRRAAL EGPRESSGPA PVEEIVRPRR ITQEDSGDDQ SVSQSNFEWP
HYVPGMVLSV LDRVPCQWRE LPLIFLPFLS VSPLPTKKHA SPPTLTPSRG ECFPCLLPAS
WTLCDITSSP PSFPGPVHFS VSCPSSEGDS DVDSELEDRV DGVKSWLSKN KGPSKAASDD
GSLKSSSPSS YQKSLALDQS VDEHAPLDHF TRSRYSHSYL SDSDTEAKLG DSSA
//
