ID F6XU04_CALJA Unreviewed; 1430 AA.
AC F6XU04;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=HFM1 {ECO:0000313|Ensembl:ENSCJAP00000049502.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000049502.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000049502.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000049502.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR STRING; 9483.ENSCJAP00000049502; -.
DR Ensembl; ENSCJAT00000063585.4; ENSCJAP00000049502.3; ENSCJAG00000001843.5.
DR GeneTree; ENSGT00550000074822; -.
DR InParanoid; F6XU04; -.
DR OMA; HCKNKHT; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000001843; Expressed in frontal cortex and 4 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Ensembl.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 288..476
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 517..718
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1109..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1430 AA; 162616 MW; 47E23BA4115573E4 CRC64;
MLKSNDCLLS LDNLFLEKPD EVENHLDNEK SLDWFLPPAP LISEIPDTQE LEEELESHRL
LGQEKRPKML TSNLKITNED INYVSPTQKF KFAFSSNKYE QVGLNLEGVG NNDLLHVAGK
LTYGSQKCKN HIDTEIAPEK SVPDNTKLVK FAEDKGESTS VFRKRLFKIS DSIHENAYCN
DSELDSDIGS VKIVQTEMNK VKSRNCSNNK QKYQYSANVF TANNAFSASE NGEDMFKAPS
FSVAFQPHDI QEVTENGSLK AVTEIPAKFR SIFKEFPYFN YIQSKAFDDL LYTDRNFVIC
APTGSGKTVV FELAITRLLM EVPLPWSNVK IVYMAPIKAL CSQRFDDWKE KFGPIGLNCK
ELTGDTVMDD LFEIQHAHII MTTPEKWDSM TRKWRDNSLV QLVRLFLIDE VHIVKDENRG
PTLEVVVSRM KTVQSVSQTL RNTSTVIPMR FVAVSATIPN AEDIAEWLSD GERPAVCLKM
DESHRPVKLQ KVVLGFPCSS NQNEFKFDLT LDYKIASVIQ MYSDQKPTLV FCATRKGVQQ
AASVLVKDAK FIMTVEQKQR LQKYAYSVRD SKLRDVLKDG AAYHHAGMEL SDRKVVEGAF
SVGDLPVLFT TSTLAMGVNL PAHLVVIKST MHYAGGLFQE YSETDILQMI GRAGRPQFDT
TATAVIMTRL STRDKYIQML ACRDTVESSL HRHLIEHLNA EIVLHTITDV NIALEWIRST
LLYIRALKNP SHYGFASGLN KDGIEAKLQE LCLKNLNDLS SLDLIKMDEG VNFKPTEAGR
LMAWYYITFE TVKKFYTISG KETLSDLVTM IAGCKEFLDI QLRINEKKTL NTLNKDPNRI
TIRFPMEGRI KTREMKVNCL IQAQLGCIPI QDFALTQDTA KIFRQGSRIT RWLSDFVAAQ
EKKFAVLLNS LILAKCFRCK LWENSQHVSK QLEKIGITLS NAIVNAGLTS FKKLEETDAR
ELELILNRHP PFGTQIKETV MYLPKYELKV EQISRYSDTT AEILVTVTLR NFEHLQTKRT
ASDSHYVTLI IGDADNQVVY LHKIMDSILL KAGNWTKKIA VKRALKSEDL SINLISSEFV
GLDIQQKFTV FYLESKRFGN QMTMRRKSET QISHSKHSNG STIAGPNKGM TASKKPGNRE
CNHPCKNKHT CGHDCCKIGV SRKSEIKEST ISSYLSDLRN RNAVSSVPPV KRLKMQMNKS
QRVDLKEFGF TPKPSLPTIS RSEYLNISEL PIMEQWDQHE ICGKFRHEPS EYQDKEVLNV
NFELGNEVWD DFDDENLKVT SFSTDTEKTK ISGFGNTLSS STRGSKLPLQ ESKDKFQREM
SNSFVSSHEM SDISLSNSAM PKFSASSMTK LPQQGTKVHF QERKQQNLSP EIERLCFTCS
EKKPNSSNYK KVDFFIRNSE CKKEVDFNRY HPDGETDEMK SLLGIFDGIF
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