ID F6XV76_ORNAN Unreviewed; 1978 AA.
AC F6XV76;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=SET binding factor 2 {ECO:0000313|Ensembl:ENSOANP00000009325.2};
GN Name=SBF2 {ECO:0000313|Ensembl:ENSOANP00000009325.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000009325.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000009325.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009325.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000009325.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009325.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR STRING; 9258.ENSOANP00000009325; -.
DR Ensembl; ENSOANT00000009327.2; ENSOANP00000009325.2; ENSOANG00000005856.4.
DR eggNOG; KOG1090; Eukaryota.
DR GeneTree; ENSGT00940000155385; -.
DR HOGENOM; CLU_047354_0_0_1; -.
DR Proteomes; UP000002279; Chromosome 3.
DR Bgee; ENSOANG00000005856; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13339; PH-GRAM_MTMR13; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037823; MTMR13_PH-GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 92..512
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1215..1748
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1872..1976
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..41
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1978 AA; 221773 MW; B1A38E3B9D7EE3E0 CRC64;
MNECRKGGRG GGEEERGAPR RRRRRLLGCQ TWPRGRRRRL RRPRENAEAL PSRGGGGGGG
GGGGGGGAAA CSDTGTRRSG AATAAMARLA DYFIVVGYDH EKTGSGEGLG KIIQRFPQKD
WEDTPFPQGI ELFCQPGGWQ LSKERKQPTF FMVVLTDIDS ERHYCSCLTF YEAEINLQGS
KHEEIEGEEE VSGLIQPAEV FAPKSLVLVS RLDYPDIFRA CLGLIYTVYV DSLSVSLESL
IANLCACLVP ASGGSQKLFS LGAGDRQLIQ TPLYDSLPVT GTSVALLFQQ LGIQNVLSLF
CAVLTENKVL FHSASFQRLS DACRALESLM FPLKYSYPYI PILPGQLLEV LSSPTPFIIG
VHSIFRSDVH ELLDVIIADL DGGTIKIPEC IHLSPLPEPL LHQTQTALSL ILHPDLEVAD
YAFPPPRTAL SHSKMLDKEV RAVFLRLFAQ LFQGYRSCLQ LIRIHAEPVI HFHKTAFLGQ
RGLIENDFLT KVLNGMAFAG FVSERGPPYR SCDLFDELVA FEVERIKVED SNPLKLIKHI
RELAEQLFRN ENPNPHMAFQ KVPRPTEGSH LRVHILPFPK INETRVQELL QEGLAKNQIT
PPPSRVEKKC VVPAGLPVVS IMDKVTTVFN SAQRLEVVRN CIAFIFENKV LETEKTLPAA
LRALKGKAAR QCLTQELGLH VQQNRAILDH QQFDYIVRMM NCTLQDCSSL EEYNIAAALL
PLTSAFYRKL APGVSQFAYT CVQDHPIWAN QQFWETTFYN DVQNQVRSLY LSAKEDNHTA
QLKQKMPDSY GIRADVRVCG QKGKENREKT PSSPNQEKSA MDLAAEQLHM WPTLSKQTQQ
ELVQNEESTV FSQAIHFANL MVNLLVPLDT SKNKLLRTSA TADWESGSNS IVTNSIAGSV
AESYDTESGF EDSESNDIAN SVVRFITRFI DKVCTESGVT QDHIKSLHCM IPGIVAMHIE
TLEAVHRESR RLPPIQKPKI LRPTLLPGEE IVCEGLRVLL DPDGREEATG GLLGGPHILP
AEGALFLTTY RIIFKGTPHD QLVGEHTVMR SFPIASITKE KKITIQNQLQ QNMQEGLQIT
SASFQLIKVA FDEEVSPEVV EIFKKQLMKY RYPQSIFSTF AFAAGQTAPQ IILPKQKEKN
TSFRTFSKTI VKGAKRAGKM TIGRQYLLKK KTGTIVEERG NRAGWNEDDD ISVSDDSELP
TSTTLKASEK STMEQLVERA CFRDYQRLGL GTISGSSSRS KSEYFRITAS NRMYSLCRSY
PGLLVVPQAV QDSSLQRVAR CYRHNRLPVV CWKNSKANTL LLRAGGFHGK GVVGLFKSQN
QHTTVPASSL DSSSSIEQEK YLQALLNAIS VHQKMSGNNT LTVRPAFALS PGTQRRASRM
STVLKQIVPE HLDVNVSNSF ARGVLGYRDK CFTHSNLKSS AKGRVHNPGV WASLRSSNRF
ISSQTSFVDV GARLAGKDHA ASFSNSAYLQ NQLLKRQAAL YIFGEKSQLR GFKLEFALNC
EFIPIEFNDI RQVKASFKKL MRACVPSTIP ADSEVTFLKA LGESEWFPQL HRIMQLAVVV
SEVLESGSSV LVCLEDGWDI TAQIVSLVQL LSDPFYRTLE GFRMLVEKEW LSFGHRFSQR
SNLTPNCQGS GFTPIFLQFL DCVHQIHNQY PTEFEFNQYY LKFLAFHYVS NRFKTFLLDS
DYERLEHGTL FEDKGDKHAK KGICIWECID KMHKRNPIFF NYLYAPTEIE ALKPSLNMSS
FKKWDYYMEE TLATGPSYDW TMLTTKYISP EEVDQGNGAV PQSKRKIVWP CYDDISRVQP
DAITSLFTPR RHPSGSSGIM SANLHSYQKR SVLHLPDSGL GEEQSASISP SNGVDRRATT
LYNQFTSKND ENRSFEGTLY KRGALLKGWK PRWFVLDVTK HQLRYYDSGE DTSCKGHIDL
AEVETVIPAT PTIGAPKHTS DKAFFDLKTS KRVYNFCAQD TQSAQQWMDR IQSCILDA
//
