ID F6XV85_HORSE Unreviewed; 1566 AA.
AC F6XV85;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 {ECO:0000313|Ensembl:ENSECAP00000007290.3};
GN Name=TRPM3 {ECO:0000313|VGNC:VGNC:24558};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007290.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007290.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007290.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007290.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007290.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSECAT00000009560.4; ENSECAP00000007290.3; ENSECAG00000008135.4.
DR VGNC; VGNC:24558; TRPM3.
DR GeneTree; ENSGT00940000157366; -.
DR HOGENOM; CLU_001390_4_1_1; -.
DR Proteomes; UP000002281; Chromosome 23.
DR Bgee; ENSECAG00000008135; Expressed in brainstem and 12 other cell types or tissues.
DR ExpressionAtlas; F6XV85; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 720..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 817..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..265
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 727..980
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1074..1129
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 654..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1077..1135
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1438..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1566 AA; 178608 MW; C13196909BB67752 CRC64;
MYVRVSFDTK ADLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT
TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP WGIVENQEDL IGRDVVRPYQ
TMSNPMSKLT VLNSMHSHFI LADNGTTGKY GAEVKLRRQL EKHISLQKIN TRIGQGVPVV
ALIVEGGPNV ISIVLEYLRD TPPVPVVVCD GSGRASDILA FGHKYSEEGG LINESLRDQL
LVTIQKTFTY TRTQAQHLFI ILMECMKKKE LITVFRMGSE GHQDIDLAIL TALLKGANAS
APDQLSLALA WNRVDIARSQ IFIYGQQWPV GSLEQAMLDA LVLDRVDFVK LLIENGVSMH
RFLTISRLEE LYNTRHGPSN TLYHLVRDVK KGNLPPDYRI SLIDIGLVIE YLMGGAYRCN
YTRKRFRTLY HNLFGPKRPK ALKLLGMEDD VPLRRGRKTT KKREEEVDID LDDPEINHFP
FPFHELMVWA VLMKRQKMAL FFWQHGEEAM AKALVACKLC KAMAHEASEN DMVDDISQEL
NHNSRDFGQL AVELLDQSYK QDEQLAMKLL TYELKNWSNA TCLQLAVAAK HRDFIAHTCS
QMLLTDMWMG RLRMRKNSGL KVILGILLPP SILSLEFKNK DDMPYMTQAQ EIHLQEKEPE
EPEKPTKEKD EEDMELTAML GRNNGESSRK KDEEEVQSRH RLIPLGRKIY EFYNAPIVKF
WFYTLAYIGY LMLFNYIVLV KMERWPSTQE WIVISYIFTL GIEKMREILM SEPGKLLQKV
KVWLQEYWNV TDLIAILLFS VGMILRLQDQ PFRSDGRVIY CVNIIYWYIR LLDIFGVNKY
LGPYVMMIGK MMIDMMYFVI IMLVVLMSFG VARQAILFPN EEPSWKLAKN IFYMPYWMIY
GEVFADQIDR KQVYDSHTPK SAPCGQNETR EDGKIIQLPP CKTGAWIVPA IMACYLLVAN
ILLVNLLIAV FNNTFFEVKS ISNQVWKFQR YQLIMTFHER PVLPPPLIIF SHMTMIFQHL
CCRWRKHESD PDERDYGLKL FITDDELKKV HDFEEQCIEE YFREKDDRFN SSNDERIRVT
SERVENMSMR LEEVNEREHC MKASLQTVDI RLAQLEDLIG RMATALERLA GLERAESNKI
RSRTSSDCTD AAYIVRQSSF NSQEGNTFKL QESIDPAGEE TMSPTSPTLM PRMRSHSFYS
VNVKDKGGIE KLESLLKERS LSLHRATSSH SVAKECKAPA APANTLAIVP DSRRPSSCID
IYVSAMDELH CDIDPLDNSM NILGLGEPSF SAPVPSTATS SSAYATLAPT DRPPSRSIDF
EDITSMDTRS FSSDYTHLPE CQNPWDTDPP MYHTIERSKS SRYLATTPFL LEEAPIVKSH
SFMFSPSRSY YANFGVPVKT AEYTSITDCI DTRCVNAPQA IADRATLPGG LGGKVEDSSC
CHPEREAELS HPSSDSEENE AKGRRATIAI PSQESDNSDR TLSNNITVPK MERANSYSAE
EPSAPYAHTR KSFSISDKLD RQRNTASLRN PFQKSKSSKP EGRGDSLSMR RLSRMSAFHS
FESKHN
//
