ID F6XXZ9_HORSE Unreviewed; 1230 AA.
AC F6XXZ9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Transcriptional regulating factor 1 {ECO:0000313|Ensembl:ENSECAP00000014660.3};
GN Name=TRERF1 {ECO:0000313|Ensembl:ENSECAP00000014660.3,
GN ECO:0000313|VGNC:VGNC:24485};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014660.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000014660.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014660.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000014660.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014660.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6XXZ9; -.
DR STRING; 9796.ENSECAP00000014660; -.
DR PaxDb; 9796-ENSECAP00000014660; -.
DR Ensembl; ENSECAT00000018003.4; ENSECAP00000014660.3; ENSECAG00000016971.4.
DR VGNC; VGNC:24485; TRERF1.
DR GeneTree; ENSGT00940000160303; -.
DR HOGENOM; CLU_009800_0_0_1; -.
DR InParanoid; F6XXZ9; -.
DR OMA; IIEDCMT; -.
DR TreeFam; TF106431; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000016971; Expressed in blood and 22 other cell types or tissues.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16089; REST COREPRESSOR COREST PROTEIN-RELATED; 1.
DR PANTHER; PTHR16089:SF19; TRANSCRIPTIONAL-REGULATING FACTOR 1; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 514..541
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 800..891
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 906..957
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 1116..1143
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 190..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..576
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1003
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 135405 MW; F70AC4AD543FDF4D CRC64;
MGDQQLYKTN HVAHSGENLF YQQPPLGVHG GLNHNYGNTV TGAAMDAPQA SPISPHFPQD
TRDGLGLPVG SKNLGQVDTS RQGGWGGHAG PGNHVQLRGN LTNSNMMWGA PAQAEPTDGY
QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA
LRQLLSQKPV EPPAPAIPSR YQQVPQQPHP GFTGGLSKPA LQVGQHPSQG HMYYDYQQPL
AQMPVPGGQP LQAPQMLSQH MQQMQQHQYY PQQQQQQAGQ QRMSMQEMQQ QQQIRPPQPQ
QQQQQQQQQQ QQQLQLQQRQ GSMQIPQYYQ SQPMMQHLQE QQQQQMHLQP PSYHRDPHQY
TPEQAHAVQL IQLGSMPQYY YQEPQQSYSH ALYQQSHLPQ HQQREDSQPK TYPSDRQAQA
MLSSHGDLGP PDAGLGDPAS SDLNRVSSAL PHRPLLSPSG IHLNNMGPQN QQLSPSAMWP
QMHLPDGRAQ PGSPESSGQL KGVFGEQFDA KNKLTCSICL KEFKSLPALN GHMRSHGGMR
ASPSLKQEEG EKAPPPQPQP PLPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ
GFANSVVAAP SARDKPASSM SDDEMPVLVR MTLSPPHSPQ GAAPRTPAEI PRKHQPGAAK
AEEPHKPAAP EKKKFRHRPE PLFIPPPPSY HPSPAASYSG ATLYQSQLRS PRVLGDHLLL
DPAHELPPYT PPPMLSPVRQ GSGLFSNVLI SGHGPGAHPQ LPLTPLTPTP RVLLCRSNSI
DGSSVTVTPG PGEQTVDIEP RINIGLRFQA EIPELQDVSA LAQDTHKATL VWKPWPELEN
HDLQQRVENL LNLCCSSALP GGGTNSEFAL HSLFEAKGDV MVALEMLLLR KPVRLKCHPL
ANYHYAGSDK WTSLERKLFN KALATYSKDF IFVQKMVKSK TVAQCVEYYY TWKKIMRLGR
RHRTRLAEII DDCVTSEEEE ELEEEDPEED RKSTREDESE VPRSPEPPPG PILAPTEGPP
LQALGQPSGS FICEMPNCGA DCRCHVTPFL PQVFSSRQAL NGHARIHGGT NQVTKARGAV
PSGKQKPGSA QSGYCSVKSS PSHSTTSGET DPTTIFPCKE CGKVFFKIKS RNAHMKTHRQ
QEEQQRQKAQ KAAFAAEMAA TIERTTGPVG APTLLPLDQL SLIKPIKDVD ILDDDMVQQL
GGVMEEAEVV DADLLLDDQD SVLLHGDTEL
//
