ID F6XZ61_HORSE Unreviewed; 350 AA.
AC F6XZ61;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=IgG receptor FcRn large subunit p51 {ECO:0000256|ARBA:ARBA00040486};
DE AltName: Full=IgG Fc fragment receptor transporter alpha chain {ECO:0000256|ARBA:ARBA00041407};
DE AltName: Full=Neonatal Fc receptor {ECO:0000256|ARBA:ARBA00041280};
GN Name=FCGRT {ECO:0000313|Ensembl:ENSECAP00000002663.3,
GN ECO:0000313|VGNC:VGNC:17976};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002663.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002663.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002663.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002663.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002663.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR AlphaFoldDB; F6XZ61; -.
DR STRING; 9796.ENSECAP00000002663; -.
DR PaxDb; 9796-ENSECAP00000002663; -.
DR Ensembl; ENSECAT00000003823.3; ENSECAP00000002663.3; ENSECAG00000002855.3.
DR VGNC; VGNC:17976; FCGRT.
DR GeneTree; ENSGT01100000263475; -.
DR HOGENOM; CLU_047501_7_0_1; -.
DR InParanoid; F6XZ61; -.
DR OMA; TWDGDWP; -.
DR TreeFam; TF336617; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000002855; Expressed in synovial membrane of synovial joint and 22 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030881; F:beta-2-microglobulin binding; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR CDD; cd21011; IgC1_MHC-like_FcRn; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF3; IGG RECEPTOR FCRN LARGE SUBUNIT P51; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..350
FT /note="IgG receptor FcRn large subunit p51"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040478200"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..284
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 350 AA; 38635 MW; A00867EF372FA36E CRC64;
MRVPPLLLLL FLLPGTLRAE SRPSLLYHFT AVSSPAPGAP AFWVSGWLGP QQYLSYNNLR
AQAEPCGAWV WENQVSWYWE KETTDLRKKE KLFLDAFQVL TEEGPHTLQG LLGCELNPDN
TSVPVAKFAL DGEDFMEFDL KLGAWNGDWP EALAIGQRWA RQADAVNNEK TFLLYSCPHR
LLGHLERGRG NLEWKEPPSM RLKARPGSPG FSVLTCSAFS FYPPELQLRF LRNGLAAGSG
EGDLGPNGDG SFYAWSSLTV KSGDEYHYRC WVQHAGLAQP LTVELESPAK SPMQVVGIVV
GVLLLLVLAA GGALLWWRMR KGLPAPWISL RGDDIGALLP APGLPKDADS
//
