ID F6Y2T6_MOUSE Unreviewed; 517 AA.
AC F6Y2T6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=WT1 transcription factor {ECO:0000313|Ensembl:ENSMUSP00000117891.2};
GN Name=Wt1 {ECO:0000313|Ensembl:ENSMUSP00000117891.2,
GN ECO:0000313|MGI:MGI:98968};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117891.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000117891.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117891.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000117891.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117891.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682}.
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DR AlphaFoldDB; F6Y2T6; -.
DR SMR; F6Y2T6; -.
DR ProteomicsDB; 372089; -.
DR Antibodypedia; 3523; 1285 antibodies from 45 providers.
DR Ensembl; ENSMUST00000143043.8; ENSMUSP00000117891.2; ENSMUSG00000016458.16.
DR UCSC; uc008lko.2; mouse.
DR AGR; MGI:98968; -.
DR MGI; MGI:98968; Wt1.
DR VEuPathDB; HostDB:ENSMUSG00000016458; -.
DR GeneTree; ENSGT00940000156734; -.
DR OMA; GQSNHTT; -.
DR PhylomeDB; F6Y2T6; -.
DR TreeFam; TF318980; -.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000016458; Expressed in gastrula and 169 other cell types or tissues.
DR ExpressionAtlas; F6Y2T6; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0010385; F:double-stranded methylated DNA binding; IEA:Ensembl.
DR GO; GO:0044729; F:hemi-methylated DNA-binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0071371; P:cellular response to gonadotropin stimulus; IEA:Ensembl.
DR GO; GO:0032836; P:glomerular basement membrane development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0072207; P:metanephric epithelium development; IEA:Ensembl.
DR GO; GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1905643; P:positive regulation of DNA methylation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0007530; P:sex determination; IEA:Ensembl.
DR GO; GO:0061032; P:visceral serous pericardium development; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR000976; Wilms_tumour_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF120; KRUEPPEL-LIKE FACTOR 15; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF02165; WT1; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Proteomics identification {ECO:0007829|ProteomicsDB:F6Y2T6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 391..420
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 421..450
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 451..478
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 482..511
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..140
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 56541 MW; 2041AB772C140DD4 CRC64;
LDFLLSQEPA STCVPEPASQ HTLRREPGCV QQPEQPGDRG PRSAWAKSSA ENPQDRRSGE
PSASEPHLMG SDVRDLNALL PAVSSLGGGG GGCGLPVSGA AQWAPVLDFA PPGASAYGSL
GGPAPPPAPP PPPPPPHSFI KQEPSWGGAE PHEEQCLSAF TLHFSGQFTG TAGACRYGPF
GPPPPSQASS GQARMFPNAP YLPSCLESQP TIRNQGYSTV TFDGAPSYGH TPSHHAAQFP
NHSFKHEDPM GQQGSLGEQQ YSVPPPVYGC HTPTDSCTGS QALLLRTPYS SDNLYQMTSQ
LECMTWNQMN LGATLKGMAA GSSSSVKWTE GQSNHGTGYE SENHTAPILC GAQYRIHTHG
VFRGIQDVRR VSGVAPTLVR SASETSEKRP FMCAYPGCNK RYFKLSHLQM HSRKHTGEKP
YQCDFKDCER RFSRSDQLKR HQRRHTGVKP FQCKTCQRKF SRSDHLKTHT RTHTGKTSEK
PFSCRWHSCQ KKFARSDELV RHHNMHQRNM TKLQLAL
//
