ID F6Y404_MONDO Unreviewed; 1755 AA.
AC F6Y404;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Crystallin beta-gamma domain containing 1 {ECO:0000313|Ensembl:ENSMODP00000029627.3};
GN Name=CRYBG1 {ECO:0000313|Ensembl:ENSMODP00000029627.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000029627.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000029627.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000029627.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
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DR STRING; 13616.ENSMODP00000029627; -.
DR Ensembl; ENSMODT00000031200.3; ENSMODP00000029627.3; ENSMODG00000023357.3.
DR eggNOG; ENOG502QUA4; Eukaryota.
DR GeneTree; ENSGT00940000155695; -.
DR HOGENOM; CLU_002648_0_0_1; -.
DR InParanoid; F6Y404; -.
DR OMA; WEAMVLT; -.
DR TreeFam; TF331078; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000023357; Expressed in placenta and 14 other cell types or tissues.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR PANTHER; PTHR11818:SF42; RICIN B-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00030; Crystall; 6.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00458; RICIN; 1.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 9.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1057..1096
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1097..1152
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1199..1241
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1253..1304
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1305..1347
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1396..1438
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1487..1530
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1536..1576
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1577..1618
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 1..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1755 AA; 192546 MW; 02A58184AD7D9D05 CRC64;
MEKRSNGRRS GRRRKSQKST DSPNGDKVPV ETHAREDSVF VEDVAPDAVA EKSSGEKKVK
SPQAATAAAV PERSASASGN PDPKTGAAHL KGHQRGDSDK SRQSQLPTVS PTKRKGRSRQ
SEASPLSPPG GYKNPGKDSP SKKQSGTAPD GNSACTPKVV AGDKSAAALG QGSENGEEGA
AAAKVIPREL TVKSSTLLPE IRPEHKRSSF LNNLDGRAEG GRNRGELGRL TASSDPDNCK
HRSHLGATRA TVTTKINLPA KPKHVELNFK APKNLESLGN DHNPFSQPVH KGNTANKISL
FENKRANNSP RNTDSRGVKS VPPSKTFVGR AKLNLGKKSK EIELLEKRGN MQNNHPNGGL
SKEVSMEKKT IPPEEHILPV TANSGETTAD CQPGPTEKAD VQRDPSCPSE QTDAAPIPSK
NVEILAENSL KTVNSTGLVL ENKIDLDKES KDSTQTVPIK SPADVLDLHP VVEMSNGPSI
PQSASVSMAA SEDTSVRCDG DAAPAGSHSG ADLKESSQPS SGSGGRAECD LPASCENNKM
TPNELGREDR SPESVEDPLN SETCEDKPSK VRVHVRSYVL PVETAQSRAP HIILDSSEVE
EVRMTSYYND GDEVDASHSC TSVKDGVPDT KATSPKDVEC KGEHPEKSRL PLELEKTVSI
QAPSDDSKIV MATESSPANS QGSKSSLELL PRPSQDIQDV EGSPASGLNV SVGSDDSTFD
SSADMEKFTE IIKKMDSSIC VPQKKKKARI PNSPAPHFAM PPIHEDNLEK VFDPNTFTYG
LGKKRENQQD ASPGLHLFQG LDTKSKLRPK RSSAEQSILF KSANTPTKNE LVECPETNGK
ENKDIANGGI KRSRLEKSAL FSSMLSSSAS TPEKVFSPSV TSVNTMTTSF GTSQNSSLLP
KPAASKIGSD GIAGLSAQSS NSENELHRLP SANSSKIFNF DSSSKSLSGL RSPNYVEKYL
QTGETKRDPD SRNNLTLTET RFSEFSKLKN NNGIEKTTSL ESTLKPQMPN FGSNDTDFMS
YLKPSIFEPS ISLAGMTLSD TPVFKASMQN KINPRPGKVV IYSEPTFSGN CFEVFSDIPN
CTSWSLSPVI IVKVVRGCWI LYEKPNFEGN SVPLEEGELE LCDPWRMEDI LVESEEDKSA
KPMVIGSIRH VIKDYRISHI DLFTETEGLG LVNSYFDDTE EMQMYGAIQK TCSIKVHWGT
WLVYEEPDFQ GIPFVLEPGE YPDLAFWGTE EAYIGSMRPL KMGGRKVEFP TDPKVIIYEK
PFFEGKCMEL ETEICNFITE GDETEEAGED NLHLKSVGSI KVLGGIWVAF EKPGFTGHQY
LLEEGEYKEW QDWGGYDGEL KSLRPILGDF SNAHMIMYSE RNFGTKGSNI DVLGIVANLK
DTGYGVKTQS INVLNGVWVA YENPDFTGEQ YILDKGLYTS FEDWGGKNCK ISSVQPICLD
TFTSPKERNK VHLFSEPEFC GSSKVFEETT NQIEDSFSAK SCRVLGGSWV AYDGENFSGN
QYVLEEGHYP SLSAMGCPPE TNFKSLRFID VEFSEPTIVL FEREDFKGKK IELNEEVVNL
RFLGFNTQIR SIQVIGGIWV TYEFSNYRGR QILLSPAEVP NWYEFSGCRQ IGSLRPFIQK
RIYFRLRNKA TGFFMSTNGN LEDLKLLRIQ VMEDVGADDQ IWIYQEGCIK CRIAEDCCLT
IVGSLVTSGS KLGLALDQNE DSQFWSIKSD GRIYSKLKPN LVLDIKGGAQ YDQNHIILNT
ANQEKMTQVW EALIL
//
