ID F6Y5B8_ORNAN Unreviewed; 1007 AA.
AC F6Y5B8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease {ECO:0000313|Ensembl:ENSOANP00000015897.4};
GN Name=DIS3 {ECO:0000313|Ensembl:ENSOANP00000015897.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000015897.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000015897.4, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000015897.4,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000015897.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000015897.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR AlphaFoldDB; F6Y5B8; -.
DR STRING; 9258.ENSOANP00000015897; -.
DR Ensembl; ENSOANT00000015900.4; ENSOANP00000015897.4; ENSOANG00000010027.4.
DR eggNOG; KOG2102; Eukaryota.
DR GeneTree; ENSGT00530000063106; -.
DR HOGENOM; CLU_002333_5_0_1; -.
DR InParanoid; F6Y5B8; -.
DR OMA; VKVHMDS; -.
DR TreeFam; TF105755; -.
DR Proteomes; UP000002279; Chromosome 2.
DR Bgee; ENSOANG00000010027; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0004519; F:endonuclease activity; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0071034; P:CUT catabolic process; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 112..231
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT DOMAIN 516..846
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 85..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 114089 MW; 0D5C112256BF9D41 CRC64;
MRAGAGFSRP FPLARRPLLL LGPSVPPSFR PSVPPPRVRA AMLKSRTFLK KTRTGGVVKV
VREHYLRDDI GCGAPACARC PAPPAPPAPP APPGGLEPRP RHPHSSLCPQ PHYLLPDTNV
LLHQIDILED PIIRNVIVLQ TVLQEVRNRS PPVYKRIRDV INNFEKHFYT FTNEHHRETY
VEQKQGESAN DRNDRAIRVA ARWYNDHLKK IKAEDNPPHV VLITNDRKNK EKAIEEGIPT
YTCEEYVKSL IANPELVDRL ASISDEKNEI ESGKIIFSEH LPLSKLQQGI KSGIYLQGTF
RASRENYLEA TVWVHGDAEE NKEIIVQGLK NLNRAVHEDI VAVELLAKNQ WVAPSSVVLL
DEGQNEDDLE MEEEKENALK TAVNEKMLRP SGRVVGIIKR NWRPFCGMLS KSLIKEARRH
LFTPADRRIP RIRIETRQAS TLDGQRIIVA IDGWPRNSRY PNGHFVKNLG TVGDKETETE
VLLLEHDVPH QPFSQAVLSF LPKMPWSITE KDMKNREDLR HLCVCSVDPP GCTDIDDALH
CRELENGNLE VGVHIADVSH FIRPGNALDQ ESAKRGTTVY LCEKRIDMVP ELLSSNLCSL
RSNVDRLAFS CIWEMNHNAE ILKTRFTKSA INSKASLTYA EAQMRIDSVS MRDDITTSLR
GLNKLAKILK KQRIDKGALT LSSPEVRFHM DSETHDPIDL QTKELKETNS MVEEFMLLAN
ISVAEKIYEE FSEHALLRKH PAPPPSNYEI LVKAAKSKDL DIKTDTAKAL AESLDGAEYP
TFPYLNTLLR ILATRCMMQA VYFCSGMDND FHHYGLASPI YTHFTSPIRR YADIIVHRLL
AVAIGADSTY PELTDKHKLA DLCKNLNFRH KMAQYAQRAS VAFHTQLFFK NKGIVNEEAY
ILFVRKNAIV VLIPKYGLEG TVFFEEKDKP KPKLTYNDEV PSLKVEDTAF HMFDKVKVKI
MLDSSNLQHQ KIRMALVEPQ IPGISIPTTA ASSNSDEPEK KKSKLEK
//
