ID F6Y5D7_MACMU Unreviewed; 402 AA.
AC F6Y5D7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Plasminogen activator inhibitor 1 {ECO:0000256|ARBA:ARBA00040523};
DE AltName: Full=Endothelial plasminogen activator inhibitor {ECO:0000256|ARBA:ARBA00041825};
DE AltName: Full=Serpin E1 {ECO:0000256|ARBA:ARBA00043166};
GN Name=SERPINE1 {ECO:0000313|Ensembl:ENSMMUP00000012989.2,
GN ECO:0000313|VGNC:VGNC:77362};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000012989.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000012989.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000012989.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR RefSeq; XP_001107647.1; XM_001107647.3.
DR AlphaFoldDB; F6Y5D7; -.
DR SMR; F6Y5D7; -.
DR MEROPS; I04.020; -.
DR PaxDb; 9544-ENSMMUP00000012989; -.
DR Ensembl; ENSMMUT00000013862.4; ENSMMUP00000012989.2; ENSMMUG00000009926.4.
DR GeneID; 713883; -.
DR KEGG; mcc:713883; -.
DR CTD; 5054; -.
DR VEuPathDB; HostDB:ENSMMUG00000009926; -.
DR VGNC; VGNC:77362; SERPINE1.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000160621; -.
DR HOGENOM; CLU_023330_0_4_1; -.
DR OrthoDB; 3218836at2759; -.
DR TreeFam; TF352620; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000009926; Expressed in fibroblast and 18 other cell types or tissues.
DR ExpressionAtlas; F6Y5D7; baseline.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02051; serpinE1_PAI-1; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF49; PLASMINOGEN ACTIVATOR INHIBITOR 1; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..402
FT /note="Plasminogen activator inhibitor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003351097"
FT DOMAIN 40..402
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 402 AA; 45083 MW; 063DAB1BA10A00C4 CRC64;
MQMSPALACL VLGLAFVFGE GSTVHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY
GVASVLAMLQ LTTGGETRQQ IQAAMGFKID DKGMAPALRH LYKELLGPWN KDEISTTDAI
FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EAERARFIIN DWVKTHTKGM ISDLLGKGAV
DQLTRLVLVN ALYFNGHWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD
GHYYDILELP YHGNTLSMFI AAPYEKQVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK
FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSNQEPLHV AQALQKVKIE VNESGTVASS
STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP
//
