ID F6Y6P2_CIOIN Unreviewed; 483 AA.
AC F6Y6P2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000026796.2, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000026796.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EAAA01000460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6Y6P2; -.
DR STRING; 7719.ENSCINP00000026796; -.
DR Ensembl; ENSCINT00000027042.2; ENSCINP00000026796.2; ENSCING00000014941.2.
DR GeneTree; ENSGT00940000167882; -.
DR HOGENOM; CLU_009051_9_0_1; -.
DR InParanoid; F6Y6P2; -.
DR OMA; FNDSGHI; -.
DR TreeFam; TF342853; -.
DR Proteomes; UP000008144; Chromosome 10.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF127; SEMAPHORIN-1A; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 1..456
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 483 AA; 54131 MW; EF16266D6CA40D6B CRC64;
NYVYMINASQ TSTSGEISYL ERLQWTSNPN SSSTCIDVGK QEYECKNFIR VVELRQDNTL
YVCGTNSYEP KCRIYTRAQF AAATPHNSPY TSEEMCNEQC GCPQNPVTTS VALYTNTSRG
FKMFSAAVTD FMGKRSYLVR SGNPSLKSVH KWLNDPSFVK LIEYGEKVYL FFREIPTSVE
TGADHLTTWS RVAQVCKDDM GGTTVLRYQW TTFLKARLTC STQGTTSRQE VFHFNNLTSV
SDVTRITGSD GRPTDVIFAT FTTPWEWSDI SMSAVCVYSI QDDIARLFDE GHFMEEQQKI
PLPKVDEPVA RPTRCNAGVS NEAEYFAKAH QIMYESVQPR YGLPIFVTES NVRLTQIALD
ENAGSSETMM LYAGTEDGKM LRIRPRLATT EGPKSVLIEE MNVADQSTCA STTSCGVRAL
HISHPELPAN VSPDLDANPK PSAFIAFTDK MIQVPLTKCD RYPNAATHCF GCCNFDPECG
WIR
//
