ID F6YCU2_XENTR Unreviewed; 1429 AA.
AC F6YCU2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Sorbin and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSXETP00000003303};
DE SubName: Full=Sorbin and SH3 domain-containing protein 2 isoform X11 {ECO:0000313|RefSeq:XP_031751980.1};
GN Name=sorbs2 {ECO:0000313|Ensembl:ENSXETP00000003303,
GN ECO:0000313|RefSeq:XP_031751980.1,
GN ECO:0000313|Xenbase:XB-GENE-478190};
GN Synonyms=argbp2 {ECO:0000313|RefSeq:XP_031751980.1}, pro0618
GN {ECO:0000313|RefSeq:XP_031751980.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000003303};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000003303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000003303};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000003303}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031751980.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031751980.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031751980.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_031751980.1; XM_031896120.1.
DR Ensembl; ENSXETT00000003303; ENSXETP00000003303; ENSXETG00000001564.
DR AGR; Xenbase:XB-GENE-478190; -.
DR Xenbase; XB-GENE-478190; sorbs2.
DR eggNOG; KOG4225; Eukaryota.
DR HOGENOM; CLU_003951_1_0_1; -.
DR TreeFam; TF320680; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000001564; Expressed in heart and 14 other cell types or tissues.
DR CDD; cd11920; SH3_Sorbs2_1; 1.
DR CDD; cd11917; SH3_Sorbs2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 137..198
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 921..980
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 996..1057
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1370..1429
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1429 AA; 159412 MW; 04AB7A99BE32DA95 CRC64;
MNTGQDSHPL DSDVWRSYND SLKDGLNDDS GGSSLTAKGF RSVRPNLQEK KSPTQTPVTV
NGSSGSPASP MSHYQRTFSP SPTYPSSRSL NSSMVMQHGA MMESTESYSQ QFPSDVSRSS
STIPICRISE EEKKVTVIKA PHYPGIGPVD ESGIPTAIRT TVDRPKDWYK TMFKQIHMVH
KPDNDMDYPS AAYAYNSDNY SATLPTFSHP AAKTHTYRPL TKSVSDNGTD VFRESSPLPP
PPVPVPPPAV PLRPREQSSL DKNEWEPPDR KVDTRRFRSE PRSIFEYEPG KSSILEHERP
TSLYQPSIEK GIERPSSSAS DYRKRRKSEP SVSHQRSHSD QNASRNTLSR IDIQSKNTTP
RKPYINSSPS SPSRAKGGDV SRMYPPLFTY SVPKQNGSNG LDYCGSYSHH LVVPHDTARS
INFKNGWQMT RQNAEVWSST EETASPKIKS RSCDDLLAED HSNFCNTQTK SESMGSLLCD
EKSPQNIPLA WGNSYKSEGC ASNQSRVRHR SAHDTPGFLK LYKKMHRINR KDLLSSEVIC
SVKSRILQYE QEQQKGLYAG WRADSEEVPR DMVPTRISEF EQLIQKSKSM PNLGDEMFSA
VSLDISTNSS CPKRRFSIES LLDEESQERH VSQVQHNGKT KSLVPVHIEV TSDQIPRSNM
DFSDSDQDAV VSDLSDFIQI EGSSFCSESD FDHYSFTSSE SFYGSGHHHH HHHHHHHHHR
HLISSCKGRC PASYTRFTTM LKHERAKQEK IESPGKHELD SGLSKIAFLV SPVPFRRKKS
ATPKKQAEKP RSKASVFEAL DSALQDICDQ IKAEKRRGSL PDNSILHRLI SELLPDVPER
NSSLKAFPLS TPLPQDGAIH YPVFQNDCES PPDGVAYQDM DATNNNAQEN SFCFQADPES
PRSYSSAFTN VTRSVARRGA QEREPARAVY DFKAQTPKEL SFSKGDTVYI LRKIDKNWYE
GEHHGRIGIF PVSYVEKMTL TEKLQPARPP PPAQAREIGE AVAKYNFTAD TNVELSLKKG
DRVLLLKQVD QNWYEGKIVG TKRQGIFPVA YVEILKKGPS KSAGDSSHCP GPQSTSIDRM
HNSSPATSAA TKRLRTPPLT LRPDSASCTD TSKGKLDAVT SEWLNLTVGF SPSTTPAPTL
PPFPDQFLSS AEKPSSLPLT VIQPEPFSSS NFTPRIEEGH FVPITSPKTI SSCHLPVPPL
FPDTVISSPI IQQIETSVMP LTNSDKCIQE ETFLAQSDIQ GLCCGKHATA ISSDLSNVSE
PVAADPIHTE SATNALSPKN LQLVDDQEEE ICEELLSIIE GGQMKSQDSG FYRCEPHAEQ
LPALYIEEDG TSENLKAPVK SITHPIAGHE ECPSSSNTER PVFTHENIQT LGEPYQSLYN
YMPRNEDELE LREGDVIDVM EKCDDGWFVG TSRRTKFFGT FPGNYVKRL
//