ID F6YDZ7_HORSE Unreviewed; 1854 AA.
AC F6YDZ7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=PI4KA {ECO:0000313|VGNC:VGNC:50961};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021362.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021362.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021362.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021362.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021362.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR Ensembl; ENSECAT00000025667.3; ENSECAP00000021362.3; ENSECAG00000023152.4.
DR VGNC; VGNC:50961; PI4KA.
DR GeneTree; ENSGT00550000074798; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000023152; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6YDZ7; baseline.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1282..1470
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1560..1838
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1854 AA; 209589 MW; 46A2747122F74223 CRC64;
MSSWECVRPW RFKKKVSPER GMPPPSSPGG SAFHCFEVSY LPDGSALEPD YYFSTISSSF
SVSPLFNGIT YKEFNIPLEM LRELLNLVKK IVEEPVLKSL DAVVASVIEA NPSADLYYST
FSDPLYVAMF KMLRDTLYYM KDLPTSFVKE IHDFVLEQFN MSQGELQKIL HDADRIHNEL
SPLKLRCQAN AACVDLMVWA VKDEQGAENL CIKLSEKLQS KTSSKVIIAH LPLLICCLQG
LGRLCERFPV VVHSVTPSLR DFLVVPSPVL VKLYKCHSQY HTVAGNDIKI SVTNEHSEPT
LNVMSGKKSQ PSMYEQLRDI AIDNICRCLK AGLTVDAVIV EAFLASLSNR LYISQESDKD
AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID QLGCLVITGN
QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA NIQDEHLVDE
LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT RRLPPIKEAK
PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK EPLRSVLQYN
SAMKNDTVTP AELSELRSTI INLLDPAPEV SALINKLDFA MSTYLLSVYR LEYMRVLRST
DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFDAFL NMMADKAKTK ENEEELERHA
QFLLVNFNHI HKRIRRVADK YLSGLVDKFP HLLWSGTVLK TMLDILQTLS LSLSADIHKD
QPYYDIPDAP YRITVPDTCE ARESIVKDFA ARCGMILQEA MKWAPTVTKS HLQEYLNKHQ
NWVSGLSQHT GLAMATESIL HFASYNKQNT TLGATQLTER PACVKKDYSN FMASLNLRNR
YAGEVYGMIR FSDATGQISD LNKMMVQELN TALDLGNAQN YTQAMFKLTA MLISSKDCDP
QLLHHLCWGP LRMFNEHGME TALACWEWLL AGKNGVEVPF MREMSGAWQM TVEQKFGLFS
AEIKEADPLA ASEASQPKPC APEVTPHYIW IDFLVQRFEI AKYCSSDQVE IFSSLLQRSM
SLNIGGAKGS MNRHVAAIGP RFKLLTLGLS LLHADVVPNA TIRNVLREKI YSTAFDYFSC
PPKFPTQGEK RLREDISIMI KFWTAMFSDK KYLTASQLVP PDNQDTRSNL DIAVGSRQQA
TQGWINTYPL SSGMSTISKK SGMSKKTNRG SQLHKYYMKR RTLLLSLLAT EIERLITWYN
PLSAPELELD QAGENSVANW RSKYISLSEK QWKDNVNLAW SISPYLAVQL PARFKNTEAI
GNEVTRLVRL DPGAVSDIPE AIKFLVTWHT IDADAPELSH VLCWAPADPP TGLSYFSSMY
PPHPLTAQYG VKVLRSFPPD AILFYIPQIV QALRYDKMGY VREYILWAAS KSQLLAHQFI
WNMKTNIYLD EEGHQKDPDI GDLLEQLVEE ITGSLSGPAK DFYQREFDFF NKITNVSAII
KPYPKGDERK KACLSALSEV KVQPGCYLPS NPEAIVLDID YKSGTPMQSA AKAPYLAKFK
VKRCGVSELE KEGLRCCSDS EDEHGAQEAD GQKISWQAAI FKVGDDCRQD MLALQIIDLF
KNIFQLVGLD LFVFPYRVVA TAPGCGVIEC IPDCTSRDQL GRQTDFGMYD YFTRQYGDES
TLAFQQARYN FIRSMAAYSL LLFLLQIKDR HNGNIMLDKK GHIIHIDFGF MFESSPGGNL
GWEPDIKLTD EMVMIMGGKM EATPFKWFME MCVRGYLAVR PYMDAVVSLV TLMLDTGLPC
FRGQTIKLLK HRFSPNMTER EAANFIMKVI QSCFLSNRSR TYDMIQYYQN DIPY
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