ID F6YE47_MACMU Unreviewed; 470 AA.
AC F6YE47;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Methyltransferase 4, N6-adenosine {ECO:0000313|Ensembl:ENSMMUP00000024936.4};
GN Name=METTL4 {ECO:0000313|Ensembl:ENSMMUP00000024936.4,
GN ECO:0000313|VGNC:VGNC:81474};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000024936.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000024936.4, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000024936.4,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000024936.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000024936.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR AlphaFoldDB; F6YE47; -.
DR STRING; 9544.ENSMMUP00000024936; -.
DR PaxDb; 9544-ENSMMUP00000024934; -.
DR Ensembl; ENSMMUT00000026644.4; ENSMMUP00000024936.4; ENSMMUG00000018950.4.
DR VEuPathDB; HostDB:ENSMMUG00000018950; -.
DR VGNC; VGNC:81474; METTL4.
DR eggNOG; KOG2356; Eukaryota.
DR GeneTree; ENSGT00390000016237; -.
DR HOGENOM; CLU_1380934_0_0_1; -.
DR InParanoid; F6YE47; -.
DR OMA; WVTNRQR; -.
DR Proteomes; UP000006718; Chromosome 18.
DR Bgee; ENSMMUG00000018950; Expressed in spermatid and 23 other cell types or tissues.
DR ExpressionAtlas; F6YE47; baseline.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0036396; C:RNA N6-methyladenosine methyltransferase complex; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IBA:GO_Central.
DR GO; GO:0032775; P:DNA methylation on adenine; IBA:GO_Central.
DR GO; GO:0080009; P:mRNA methylation; IBA:GO_Central.
DR GO; GO:0090296; P:regulation of mitochondrial DNA replication; IEA:Ensembl.
DR GO; GO:1903108; P:regulation of mitochondrial transcription; IEA:Ensembl.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:Ensembl.
DR GO; GO:0120049; P:snRNA (adenine-N6)-methylation; IEA:Ensembl.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829:SF4; N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4; 1.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
SQ SEQUENCE 470 AA; 53700 MW; D56C1ABD7E57F32D CRC64;
MSVVHQLSAG WLLDHLSFIN KINYQLHQHH EPCCSKNEFT TSVHFESLQM DSVSSSGACA
AFIASDPTTK PENDDGGNYE MLTQKFVFRP ELFDVTKPYI TPAVHKECQQ SNEKEDLMNG
VKKEISISII GKKRKRCVVF NQGELDAMEY HTKIRELILD GSLQLIQEGL KSGFLYPLFE
KQDKCSKPIT LPLDTCNLPE LCEMAKHLPS LNEMEHQTLQ LVEEDTSVTE QDLFLRVVEN
NSSFTKVITL MGQKYLLPPK SSFLLSDISC MQPLLNYRKT FDVIVIDPPW QNKSVKRSNS
YLSPLQIKQI PIPKLAAPNC LLVTWVTNRQ KHLRFIKEEL YPSWSVEVVA EWHWVKITNS
GEFVFPLDSP HKKPYEGLIL GRVQEKTALP LRNADVNVLP IPDHKLIVSV PCTLHSHKPP
LAEVLKDYIK PDGEYLELFA RNLQPGWTSW GNEVLKFQHV DYFIALESGS
//