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Database: UniProt
Entry: F6YFJ5_HORSE
LinkDB: F6YFJ5_HORSE
Original site: F6YFJ5_HORSE 
ID   F6YFJ5_HORSE            Unreviewed;      2062 AA.
AC   F6YFJ5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   20-JUN-2018, entry version 53.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1C {ECO:0000313|VGNC:VGNC:15982};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019450, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000019450, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019450,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000019450}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019450};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   STRING; 9796.ENSECAP00000019450; -.
DR   PaxDb; F6YFJ5; -.
DR   Ensembl; ENSECAT00000023480; ENSECAP00000019450; ENSECAG00000019096.
DR   VGNC; VGNC:15982; CACNA1C.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F6YFJ5; -.
DR   OMA; PTTKINM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002281; Chromosome 6.
DR   Bgee; ENSECAG00000019096; -.
DR   ExpressionAtlas; F6YFJ5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0061577; P:calcium ion transmembrane transport via high voltage-gated calcium channel; IEA:Ensembl.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0002520; P:immune system development; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0098912; P:membrane depolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 6.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      5     24       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     36     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    109    131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    223    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    366    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    403    426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    495    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    567    594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    737    760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    772    791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    798    820       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    832    858       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    879    912       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1004   1030       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1081   1098       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1110   1132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1144   1161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1248   1271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1341   1365       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1499   1533       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      597    623       {ECO:0000256|SAM:Coils}.
FT   COILED     1460   1480       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2062 AA;  231697 MW;  37F630807851FE5D CRC64;
     ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAE
     GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
     IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG TVCKPGWDGP
     KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWVNDAVGRD WPWIYFVTLI IIGSFFVLNL
     VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDEE
     KPRNMSMPTS ETESVNTENV AGGDIEGENC GARLAHRISK SKFSRYWRRW NRFCRRKCRA
     AVKSNIFYWL VIFLVFLNTL TIASEHYNQP HWLTEVQDTA NKALLALFTT EMLLKMYSLG
     LQAYFVSLFN RFDCFIVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK ITRYWNSLSN
     LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF DNFPQSLLTV
     FQILTGEDWN SVMYDGIMAY GGPSFPGMLV CIYFIILFIC GNYILLNVFL AIAVDNLADA
     ESLTSAQKEE EEEKERKKLA RTASPEKKQE VVEKPAVEEA KEEKIELKSI TADGESPPTT
     KINMDDLQPN ENEDKSPYSN PETAGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA
     FFIFSPNNRF RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR NHILFYFDIV
     FTTIFTIEIA LKILGNADYV FTSIFTLEII LKMTAYGAFL HKGSFCRNYF NILDLLVVSV
     SLISFGIQSS AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL
     QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG EVDHPIIQPR SWENSKFDFD
     NVLAAMMALF TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR VEISIFFIIY IIIIAFFMMN
     IFVGFVIVTF QEQGEQEYKN CELDKNQRQC VEYALKARPL RRYIPKNQHQ YKVWYVVNST
     YFEYLMFVLI LLNTICLAMQ HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKGYF
     SDPWNVFDFL IVIGSIIDVI LSETNHYFCD AWNTFDALIV VGSIVDIAIT EVNPAEHTQC
     SPFMNAEENS RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP YVALLIVMLF
     FIYAVIGMQV FGKIALNDTT EINRNNNFQT FPQAVLLLFR CATGEAWQDI MLACMPGKKC
     APESEPSNST EGETPCGSSF AVFYFISFYM LCAFLIINLF VAVIMDNFDY LTRDWSILGP
     HHLDEFKRIW AEYDPEAKGR IKHLDVVTLL RRIQPPLGFG KLCPHRVACK RLVSMNMPLN
     SDGTVMFNAT LFALVRTALR IKTEGNLEQA NEELRAIIKK IWKRTSMKLL DQVVPPAGDD
     EVTVGKFYAT FLIQEYFRKF KKRKEQGLVG KPSQRNALSL QAGLRTLHDI GPEIRRAISG
     DLTAEEELDK AMKEAVCAAS EDDIFRRAGG LFGNHVSYYQ SDGRSAYPQT FTTQRPLHIN
     KAGNSQGDTE SPSHEKLVDS TFTPSSYSST GSNANINNAN NTALGRFPRP TGYPSAVSTV
     EGHGLPLSPA IRVQEAAWKL SSKSEGRQTP ACQGLRLSRG SGSAGAQVHA PLLGRINPLF
     VCPSRESQIA MVCQEEVSHE ETYDVKMSED PQRGSEPSLI STERLSYQDD EHRQLTPPEE
     DKRDIRQSPK RGFLRSASLG RRASFHLECL KRQKSQGGDV SQKTVLPLHL VHHQALAVAG
     LSPLLQRSRA PTTCPQPWAT PSSQGWPPRP IPTLRLEGAE SSEKLNSSFP SIHCGSWSGE
     PTACGGGSSA LRRARPVSLT VPSRAGAPGR QLHGSASSLV EAVLISEGLG QFAQDPKFIE
     VTTQELADAC DMTIEEMENA ADNILSGGTQ QSANGTLFPF VNCRDPGQDR AGGEENETCA
     PALERGKSEG EPQDSRACGG SL
//
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