ID F6YFL6_HORSE Unreviewed; 736 AA.
AC F6YFL6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Rho related BTB domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000021764.3};
GN Name=RHOBTB2 {ECO:0000313|Ensembl:ENSECAP00000021764.3,
GN ECO:0000313|VGNC:VGNC:22373};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021764.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021764.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021764.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021764.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021764.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YFL6; -.
DR STRING; 9796.ENSECAP00000021764; -.
DR PaxDb; 9796-ENSECAP00000021764; -.
DR Ensembl; ENSECAT00000026117.3; ENSECAP00000021764.3; ENSECAG00000024136.4.
DR CTD; 23221; -.
DR VGNC; VGNC:22373; RHOBTB2.
DR GeneTree; ENSGT00940000158918; -.
DR HOGENOM; CLU_015517_0_0_1; -.
DR InParanoid; F6YFL6; -.
DR OMA; TIDKDCN; -.
DR OrthoDB; 2898387at2759; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000024136; Expressed in trophoblast and 23 other cell types or tissues.
DR ExpressionAtlas; F6YFL6; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0032488; P:Cdc42 protein signal transduction; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR CDD; cd18531; BACK_RHOBTB2; 1.
DR CDD; cd18359; BTB2_POZ_RHOBTB2; 1.
DR CDD; cd01873; RhoBTB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR PANTHER; PTHR24072:SF137; RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00651; BTB; 3.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00225; BTB; 2.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54695; POZ domain; 2.
DR PROSITE; PS50097; BTB; 3.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 273..303
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 376..451
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 509..576
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 311..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 83875 MW; 1A9C0F7E9D57E39B CRC64;
REERSQLMDS DMDYERPNVE TIKCVVVGDN AVGKTRLIRA RACNATLTQY QLLATHVPTV
WAIDQYRVCQ EVLERSRDVV DDVSVSLRLW DTFGDHHKDR RFAYGRSDVV VLCFSIANPN
SLHHVKTMWY PEIKHFCPRA PVILVGCQLD LRYADLEAVN RARRPLARPI KPNEILPPEK
GREVAKELGI PYYETSVVAK FGIKDVFDNA IRAALISRRH LQFWKSHLRN VQRPLLQAPF
LPPKPPPPII VVPDPPSSSE ECPAHLLEDP LCADVILVLQ ERVRIFAHKI YLSTSSSKFY
DLFLMDLSEG ELGGPSGPGG PRPEDHRGHP DQHHHHHHHH HHHGRDFLLR AASFDVCESV
EEGGGSGPAG LRASTSDGIL RGNGTGYLPG RGRVLSSWSR AFVSIQEEMA EDPLTYKSRL
MVVVKMDNSI QPGPFRAVLK YLYTGELDEK ERDLMHIAHI AELLEVFDLR MMVANILNNE
AFMNQEITKA FHVRRTNRVK ECLAKGTFSD VTFILDDGTI SAHKPLLISS CDWMAAMFGG
PFVESSTREV VFPYTSKSCM RAVLEYLYTG MFTSSPDLDD MKLIILANRL CLPHLVALTE
QYTVTGLMEA TQMMVDIDGD VLVFLELAQF HCAYQLADWC LHHICTNYNN VCRKFPRDMK
AMSPENQEYF EKHRWPPVWY LKEEDHYQRA RKEREKEDYL HLKRQPKRRW LFWNSPSSPS
SSAASSSSPS SSSAVV
//
