ID F6YFW3_XENTR Unreviewed; 944 AA.
AC F6YFW3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Sarcosine dehydrogenase {ECO:0000313|Ensembl:ENSXETP00000049980};
GN Name=sardh {ECO:0000313|Ensembl:ENSXETP00000049980};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000049980};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000049980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000049980};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000049980}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR AlphaFoldDB; F6YFW3; -.
DR Ensembl; ENSXETT00000049980; ENSXETP00000049980; ENSXETG00000023098.
DR AGR; Xenbase:XB-GENE-6038613; -.
DR Xenbase; XB-GENE-6038613; sardh.
DR eggNOG; KOG2844; Eukaryota.
DR HOGENOM; CLU_007884_11_4_1; -.
DR InParanoid; F6YFW3; -.
DR TreeFam; TF314735; -.
DR Bgee; ENSXETG00000023098; Expressed in mesonephros and 12 other cell types or tissues.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF200; SARCOSINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
FT DOMAIN 94..453
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 456..510
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 514..823
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 849..934
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
FT REGION 61..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 103983 MW; 8ABC365465223D34 CRC64;
MVPSITASLP GPEAAKQPQT INTTTTIFLL LGAMRYLGRA VRGATRLRAA VAKASSFGSV
AGHTSEKSVP YASTLKEERS AGTGPTKPLP RSADVVVIGG GSLGCQTTYH LAKMGVTNVV
LLERDRLTSG TTWHTAGLLW QLRPSDVEVE LLAHTRDVVS RELEQETGLH TGWIENGGLF
IASNKQRLDE YKRLMSLGKV YGVESYVLSP AQTKDLYPLM NVDDLYGTLY VPKDGTMDPA
GTCTTLARAS SARGAQVIEN CPVTGIRVKT DDLGVRRVVA VETLHGTVET PCVVNCAGAW
APKLGQMAGV NVPLVAMHHA YVVTERIEGI QNMPNVRDHD ASVYLRLQGD ALSVGGYESN
PIFWEKVSDK FAFGLFDLDW DVFIQHIQGA INRVPALEQT GIKSTVCGPE SFTADHKPLL
GESPEVRGFF LGCGFNSAGM MLGGGCGKEL AHWIIHGRPE KDMYGYDIRR FHRSLTNHNR
WIRERSHESY AKNYSVVFAY DEPLAGRNMR KDPLHEELLG QGCVFQERHG WERPGWFNPE
GPAPVLDYDY YGAYGLEPHQ EYQYSRLLGK EYTFNFPPHH DVIRRECLMC RNQAAVFNMS
YFGKFYLLGP DAKKAANWLF TADINKPPGT TVYTCMLNKQ GGAESDLTVS CLEPGTGGSD
LAPQFEGEGY YLAIGGAVAQ HNWSHISTVL QDEKFDCKLV DSSEDQGMIS IQGPASRTIL
QEVLDEDLSN EAFPFSTHKL VTAAGFTVRA IRLSFVGEMG WELHMPREAC VPVYKAVMAA
GAKHGMGNAG YRAIDSLSIE KGYRHWHADL RPDDSPLEAG LAFTCKLKSA IPFLGRGALE
RQKALGLKKR LVCFTLSEKV PLFGLEAIWR NGIAVGHVRR ADYGFTINKT IAYGYIRNPE
GGAVSPDFVR SGEYKLERMG IAYPAEAHLK SPFDPNNMRV KGFY
//
