ID F6YI63_CALJA Unreviewed; 371 AA.
AC F6YI63;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=SIX homeobox 3 {ECO:0000313|Ensembl:ENSCJAP00000001262.5};
GN Name=SIX3 {ECO:0000313|Ensembl:ENSCJAP00000001262.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000001262.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000001262.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000001262.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR AlphaFoldDB; F6YI63; -.
DR STRING; 9483.ENSCJAP00000001262; -.
DR Ensembl; ENSCJAT00000001337.5; ENSCJAP00000001262.5; ENSCJAG00000000736.5.
DR eggNOG; KOG0775; Eukaryota.
DR GeneTree; ENSGT00940000160346; -.
DR InParanoid; F6YI63; -.
DR OMA; PGCPTHN; -.
DR TreeFam; TF315545; -.
DR Proteomes; UP000008225; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF31; HOMEOBOX PROTEIN SIX3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 224..284
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 226..285
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 268..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 40394 MW; 5C9CB368EE66AFDA CRC64;
MNIYPPLLRA PGFPYLSAGQ SMVFRSPLDL YSSHFLLPNF ADSHHRSILL ASSGGGNCAG
GGGGAGGCSG GGNVAGGGGA GGAGGSGGGS RAPPEELSMF QLPTLNFSPE QVASVCETLE
ETGDIERLGR FLWSLPVAPG ACEAINKHES ILRARAVVAF HTGNFRDLYH ILENHKFTKE
SHGKLQAMWL EAHYQEAEKL RGRPLGPVDK YRVRKKFPLP RTIWDGEQKT HCFKERTRSL
LREWYLQDPY PNPSKKRELA QATGLTPTQV GNWFKNRRQR DRAAAAKNRL QHQAIGPSGM
RSLAEPGCPT HGSAESPSTA ASPTTSVSSL TERADTGTSI LSDKHGFSFR FPWTRHPTCM
TIYLYLGKYS L
//
