ID F6YIW6_HORSE Unreviewed; 893 AA.
AC F6YIW6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=LDL receptor related protein 12 {ECO:0000313|Ensembl:ENSECAP00000031385.2};
GN Name=LRP12 {ECO:0000313|Ensembl:ENSECAP00000031385.2,
GN ECO:0000313|VGNC:VGNC:19760};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000031385.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000031385.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000031385.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000031385.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000031385.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; F6YIW6; -.
DR STRING; 9796.ENSECAP00000031385; -.
DR PaxDb; 9796-ENSECAP00000031385; -.
DR Ensembl; ENSECAT00000050603.3; ENSECAP00000031385.2; ENSECAG00000016556.4.
DR CTD; 29967; -.
DR VGNC; VGNC:19760; LRP12.
DR GeneTree; ENSGT00940000158307; -.
DR HOGENOM; CLU_013747_0_0_1; -.
DR InParanoid; F6YIW6; -.
DR OMA; YTCIPES; -.
DR OrthoDB; 2916406at2759; -.
DR Proteomes; UP000002281; Chromosome 9.
DR Bgee; ENSECAG00000016556; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; F6YIW6; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF47; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..893
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040303700"
FT DOMAIN 47..159
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 258..371
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 656..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 166..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 173..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 185..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 238..253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 394..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 432..447
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 450..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 457..475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 469..484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 893 AA; 98523 MW; C74EF14FE9BE0376 CRC64;
MARRWSTKES PRWRSALVLL FFAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI
ITSPGWPSEY PAKTNCSWFI RANPGEIITI SFQDFDIQGS RRCSLDWLTI ETYKNIESYR
ACGSTIPPPY ISSQDHIWIR FHSDDSISRK GFRLSYFSGK SEEPNCACDQ FRCGNGKCIP
EAWKCNNMDE CGDSSDEEIC AREAPPTSAS FQPCAYNQFQ CLSRFTKVYT CLPESLKCDG
NIDCLDLGDE IDCDVPTCGQ WLKYFYGTFN SPNYPDFYPP GSNCTWLIDT GDHRKVILRF
TDFKLDGTGY GDYVKIYDGL EENPHKLLRV LTAFDSHAPL TVVSSSGQIR VHFCADKVNA
ARGFNATYQV DGFCLPWEIP CGGNWGCYTE QQRCDGYWHC PNGRDEINCT MCQKEEFPCS
RNGVCYPRSD RCNYQNHCPN GSDEKNCFFC QPGNFHCKNN RCVFESWVCD SQDDCGDGSD
EENCPVIVPT RVITAAVIGS LICGLLLVIA LGCTCKLYSL RMFERRAYDT CEGLIGDKTG
TTGLVSYCGL SESQVSEFSV QSFETQLSRV EAELLRREAP PSYGQLIAQG LIPPVEDFPV
CSPNQASVLE NLRLAVRSQL GFTSIRLPMA GRSSNIWNRI FNFARSRHSG SLALVSADGD
EVGPSQSTNR EPERSHTHRS LFSVESDDTD TENERRDTAG ASGGVAAPLP QKVPPITAVE
ATVGASGSSS TQSTRGGHTD NGRDVTSVEP PSVSPARHQL TSALSRMTQG LRWVRFTLGR
SSSVNQNQSP LRQLDNGVNG REEDDDVEML IPVSDGASDF DVNDCSRPLL DLASDQGQGF
RQPYSATNPG VRPSSRDGPC ERCGIVHTAQ IPDTCLEATL KNETSDDEAL LLC
//
