GenomeNet

Database: UniProt
Entry: F6YJZ2_MONDO
LinkDB: F6YJZ2_MONDO
Original site: F6YJZ2_MONDO 
ID   F6YJZ2_MONDO            Unreviewed;      3135 AA.
AC   F6YJZ2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUN-2019, entry version 66.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000022011};
GN   Name=LAMA2 {ECO:0000313|Ensembl:ENSMODP00000022011};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000022011, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000022011, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000022011}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   STRING; 13616.ENSMODP00000022011; -.
DR   Ensembl; ENSMODT00000022398; ENSMODP00000022011; ENSMODG00000017651.
DR   eggNOG; ENOG410IP69; Eukaryota.
DR   eggNOG; COG0419; LUCA.
DR   GeneTree; ENSGT00940000155362; -.
DR   InParanoid; F6YJZ2; -.
DR   OMA; FGPCNCK; -.
DR   TreeFam; TF335359; -.
DR   Proteomes; UP000002280; Chromosome 2.
DR   Bgee; ENSMODG00000017651; Expressed in 8 organ(s), highest expression level in heart.
DR   GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR   GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR   GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00052; Laminin_B; 2.
DR   Pfam; PF00053; Laminin_EGF; 16.
DR   Pfam; PF00054; Laminin_G_1; 4.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 10.
DR   SMART; SM00180; EGF_Lam; 16.
DR   SMART; SM00281; LamB; 2.
DR   SMART; SM00282; LamG; 5.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 6.
DR   PROSITE; PS50027; EGF_LAM_2; 15.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR   PROSITE; PS51115; LAMININ_IVA; 2.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   3135       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003346868.
FT   DOMAIN       40    291       Laminin N-terminal. {ECO:0000259|PROSITE:
FT                                PS51117}.
FT   DOMAIN      292    348       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      349    418       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      419    473       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      474    522       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      543    728       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN      762    811       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      812    869       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      870    922       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      923    971       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      972   1018       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1019   1064       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1065   1110       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1111   1170       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1185   1384       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN     1425   1473       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1474   1531       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1532   1578       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2151   2334       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2346   2527       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2532   2716       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2776   2947       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2952   3132       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED     1638   1658       {ECO:0000256|SAM:Coils}.
FT   COILED     1705   1850       {ECO:0000256|SAM:Coils}.
FT   COILED     1865   1885       {ECO:0000256|SAM:Coils}.
FT   COILED     1936   1960       {ECO:0000256|SAM:Coils}.
FT   COILED     1986   2013       {ECO:0000256|SAM:Coils}.
FT   COILED     2039   2080       {ECO:0000256|SAM:Coils}.
FT   COILED     2098   2146       {ECO:0000256|SAM:Coils}.
FT   DISULFID    314    323       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    386    395       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    419    431       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    449    458       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    493    502       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    781    790       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    840    849       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    894    903       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    906    920       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    923    935       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    925    942       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    944    953       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    972    984       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    992   1001       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1037   1046       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1065   1077       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1067   1084       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1086   1095       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1111   1123       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1141   1150       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1444   1453       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1502   1511       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1532   1544       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1534   1551       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1553   1562       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2689   2716       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   3135 AA;  345364 MW;  D2293C8B11B2DAA0 CRC64;
     MPGQAWHFLL LLITGLGCPK NNRAQQQQKR ALSHLQQTHQ QRGLFPAVLN LATNALITTN
     ATCGERGPEM YCKLVEHVPG QPVRNPQCRT CNQNSSFAYQ RHPITNAIDG KNTWWQSPSI
     KNGIEYHYVT ITLDLQQVFQ IAYVIVKASN SPRPGNWILE RSLDGVEYKP WQYHAITDTE
     CLTRYGIYPR TGPPSYAKDD EVICTSFYSK IHPLENGEIH ISLINGRPSA DDPSPELLEF
     TSARYIRLRF QRIRTLNADL MMFAHKDPRE IDPIVTRRYY YSVKDISVGG MCICYGHARA
     CPLDPSTNKS RCECEHNTCG DSCDQCCPGF HQKPWKAGTF LTKTECEACN CHGKAEECYY
     DENVASRNLS LNIHGKYIGG GVCINCTQNT TGINCETCID GFFRPKGVSP NYPSPCQPCY
     CDPIGSIHEV CVKDENHARR GLFPGSCHCK HGFEGVRCDR CARGYTGYPD CVQCNCSGAG
     STNHDPCIGT CNCKENVEGR DCSHCKVGFF NLQENNHKGC EECFCSGVSD RCQSSRWTYS
     NINDMNGWYV TDVSGLLRVA PHHDNSDQSQ QLSINSKDAK RKLPQIYYWS APGPYLGNKV
     TAAGGQLKFT ISYDLTGEED DLENVLQFMV ILEGNGLQIS TPQEEIYLSP SEEYRHVVLL
     HSELFNVHGT GAQVSRKEFM TVLANLKRLL IQATYVFGMD AIFRLEAVGL ESAVPYPTDG
     DLAEAVEFCQ CPAGYSGSSC ESCWPGHRRV NGTIFGGICE PCQCFGHAEV CDDITGECMG
     CKDNTGGPYC DRCLPGFYGD PSKGTADDCQ PCACPLNIPS NNFSPTCHLD WSRGLICDEC
     PVGYTGPRCE RCAEGYFGQP SIPGGSCQPC QCNDNLDFSI PGSCDSLSGS CLICKPGTTG
     RYCERCADGY FGDAIDAKNC QPCRCNINGS FSEICHTKTG QCECRLNVQG LRCDECQPQT
     FGLQSSQGCV PCNCNSFGSK SFDCEESGQC WCQPGVAGKK CDRCAHGYFK FQEGGCTPCE
     CAHLGNNCDP NTGQCICPPN TIGEKCDKCA PNSWGHSIIT GCKACNCSLV GSFDFQCNAN
     TGQCSCHPEF SGTKCTECNL GHWNYPHCNL CDCFLAGTDV STCNSETEKC ACLNHNGQCT
     CKVNVEGVHC DRCRPGKFGL DAKNPLGCSS CYCFGTTTQC TEARGLIRMW VTLTPEQTIL
     PLVDEALQHT TTKGIVFQHP EIVADMELVG EDLHLEPFYW KLPEQFEGKK LMAYGGKLKY
     TIYFEAREET GFSTYNPQVI IRGGTPARAR IISQHMAAPL IGQLTRHEIE MTENEWKYYG
     DDPRTSRMVT REDFLDVLYD IHYILIKATY GNIIRQSRIS EIAMEVAEEG AVSALSSRAR
     LIEKCDCPLG YSGLSCEACM PGFYRLPSEP GGRIPGPSLG TCVPCQCNGH SDTCDAETSI
     CQNCQHHTAG DFCERCALGY YGTVKGLPND CRQCACPLIT SSNNFSPSCI AEGLDDYRCT
     ACPRGYEGQY CERCAFGYTG SPSSPGGSCQ ECECDPYGSL PVPCDPVTGH CTCRPGATGQ
     KCDGCKPGHA RDGMECVFCG DECTGLLLGD LARLEQMAVS INLTGPLPAP YKMLYNFENV
     TQELKHSLSP QRAPERLLQL AESNLNTLVT EMDELLTRAT KVTADGEQTG QDAERTNMRA
     KMLSGIVKEI VQDAEAVNEK AIKLNETLGA QDKALEKSFQ ELQQEIDQMM AELRQKNLDM
     QNEVAQDELV AAEALLRKVK KLFGESRGKN EELEKEVRDK LMDYQSKIDD AQDLLKEATD
     KIKEADRLSE TNQKNMTDLE KKRQAVESGK QEAENTLKEG NDILDEANHL VDEINSVIDF
     VKDIQEKLPQ ESEELKNKID DLSQEIKDRR LPEKVLQAED HAARLNESSA VLDGILEEAK
     NISFNATAAF KAYSNIKDYI DEAERVAKEA KGHANEATQL ASGPRGSLKD DAKGSLQKSF
     RVLNEAKRLA NDVKENDDNL KGLKSRLENA NEKNGDLLKG LNDTLGKLSA IPSDTATKLQ
     AVKDKARQAN DTAKDVLAQI KDLNQNLAGL RNNYNKLADD VAKTNAVVKD PAKNSKLFAD
     ADATVKNLEE EADRLIDKLK PIKELQDNLK KNISEIKELI NQARKQANSI KVSVSSGGDC
     IRTYRPEIKK GSYNNIIVNV KTAVADNLLF YLGSAKFTDF LAIEMRKGKV SFLWDVGSGV
     GRVEYPDLTI DDSYWYRIEA SRTGRNGTIS VRALDGPKAS IIPITYNSIS PPGYTILDVD
     ANAMLFVGGL TGKLKKADAV RVITFTGCMG ETYFDSKPIG LWNFRDIEGD CKGCTVSPQV
     EDTEGTIQFD GEGYALVSRP IRWYPNISTV MFKFRTFSSS ALLMYLATRD LKDFMSVELT
     DGHIKVSYDL GSGIASVISN QNHNDGKWKS FTLSRIQKQA NVSIIDIETN QEENIATASS
     GNNFGLDLKA DDKIYFGGLP TLRNLSYFDR PEVNLKKYAG CLKDIEISRT PYNILSSPDY
     VGVTKGCSLE NVYIVSFPKP GFVELSPVPF DVGTEINLSF STKNESGIIL LGSDGPNTSP
     RRKRRQTGQA YYAIFLNKGR LEVHLSTGVR TMRKIVVKPE LIPFHDGREH SIHVERARGM
     FTVQVDEDRK HMQNLTVEQS ISIKKLFVGG SPSQFQPSPL RTIPPFEGCI WNLVINAIPM
     DFAQSVSFKN ADIGRCLDHK PGEGEVTSEQ IIFPPDSGPE EKETTPAFPF PSPPPTPALA
     HGPCAADTKP ALLIGSKQFG LSKNSHIAIA FDDTKVKNSL TIEFEIRTEA ESGLMFYMAR
     INHADFATVQ LKNGMPYFSY DLGSGNTSTM ISTRINDGQW HKIKIFRTKQ EGILYVDGAS
     NKTTSPKKAD ILDVVGMLYV GGLPINYTTR RIGPVVYSID GCMKNLKMAE APTDLENPTS
     SFNVGTCFAN AQKGTYFDGT GFAKAVGAYK VGLDLLVEFE FRTTRTTGVL LGISSQKMDG
     MGIELVDEKL MFHVDNGAGR FTATYDAGVP GTLCDGQWHK VTANKIKHRL ELKVDGNQVG
     AQSSNTASTS ADTNDPVFVG GYPDDLNQFG LTTNIPFRGC IRSLKLTKGT AKALEINFAK
     ALELKGVQPV SCPAN
//
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