ID F6YK16_ORNAN Unreviewed; 729 AA.
AC F6YK16;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Muskelin 1 {ECO:0000313|Ensembl:ENSOANP00000018181.4};
GN Name=MKLN1 {ECO:0000313|Ensembl:ENSOANP00000018181.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000018181.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000018181.4, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018181.4,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000018181.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018181.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YK16; -.
DR STRING; 9258.ENSOANP00000018181; -.
DR Ensembl; ENSOANT00000018184.4; ENSOANP00000018181.4; ENSOANG00000011473.4.
DR eggNOG; KOG2437; Eukaryota.
DR GeneTree; ENSGT00390000001702; -.
DR HOGENOM; CLU_004210_1_0_1; -.
DR TreeFam; TF323659; -.
DR Proteomes; UP000002279; Chromosome 10.
DR Bgee; ENSOANG00000011473; Expressed in liver and 8 other cell types or tissues.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR010565; Muskelin_N.
DR PANTHER; PTHR15526; MUSKELIN; 1.
DR PANTHER; PTHR15526:SF5; MUSKELIN; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF06588; Muskelin_N; 1.
DR SMART; SM00667; LisH; 1.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50896; LISH; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..149
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 200..252
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
SQ SEQUENCE 729 AA; 84399 MW; B0DB886252C2F532 CRC64;
MDNSLEKGTQ FSTSSYKMLH GFCEEQRNIL VDKPNDQSSR WSSESNYPPQ YLILKLERPA
IVQSITFGKY EKTHVCNLKK FKVFGGMNEE NMTELLSSGL KNDYNKETFT LKHKIDEQMF
PCRFIKIVPL LSWGPSFNFS IWYVELNGID EPDVVQPCLN WYSKYREQEA IRLCLKHFRQ
HNYTEAFESL QKKTKIALEH PMLTDLHDKL VLKGDFDACE ELIEKAVNDG LFNQYISQQE
YKPRWSQIIP KSTKGDGEDS RPGMRGGHQM VIDVQTETVY LFGGWDGTQD LADFWAYSVK
ENQWTCISRD TEKENGPSAR SCHKMCIDIQ RRQIYTLGRY LDSSVRNSKS LKSDFYRYDI
DSNTWMLLSE DTAANGGPKL VFDHQMCMDS EKHMIYTFGG RILTCNGSVD DSRASEPQFS
GLFAFNCQCQ TWKLLREDSC NAGPEDIQSR IGHCMLFHSK NRCLYVFGGQ RSKTYLNDFF
SYDVDSDHVD IISDGTKKDS GMVPMTGFTQ RATIDPELNE IHVLSGLSKD KEKREENVRN
SFWIYDIVRN SWSCVYKNDQ AAKDNPNKSL QEEEPCPRFA HQLVYDELHK VHYLFGGNPG
KSCSPKMRLD DFWSLKLCRP SKEYLLRHCK YLIRKHRFEE KAQTDPLSAL KYLQNDLYVT
VDHSDPEETK EFQLLASALF KSGSDFTALG FSDVDHTYAQ RTQLFDTLVN FFPDSMTPPK
GNLVDLITL
//
